White crystalline powder
fructus of Cnidium monnieri (L.) Cusson
Ostol/7-methoxy-8-(3-methylbut-2-en-1-yl)-2H-1-benzopyran-2-one/Cnidium Monnieri Extract/DaMiana Extract/7-methoxy-8-(3-methylbut-2-enyl)chromen-2-one/7-Methoxy-8-isopentenylcoumarin/7-Methoxy-8-(3-methyl-2-butenyl)coumarin/Osthol/Osthole/7-Methoxy-8-(3-methyl-2-buten-1-yl)-2H-chromen-2-one/7-methoxy-8-(3-methylbut-2-enyl)-2H-chromen-2-one/7-methoxy-8-(3-methyl-2-buten-1-yl)-2H-1-benzopyran-2-one/Ostole/2H-1-Benzopyran-2-one, 7-methoxy-8-(3-methyl-2-buten-1-yl)-/7-methoxy-8-isopentenoxycoumarin/2H-1-Benzopyran-2-one, 7-methoxy-8- (3-methyl-2-butenyl)-/7-Methoxy-8-(3-Methyl-But-2-Enyl)-Chromen-2-One/Chuanxiongzine/Osthole/7-methoxy-8-(3-methylbut-2-en-1-yl)-2H-chromen-2-one/Coumarin, 7-methoxy-8- (3-methyl-2-butenyl)-/OSTHOL/Cnidium/7-Methoxy-8-(3-methyl-2-butenyl)coumarin,7-Methoxy-8-isopentenylcoumarin,Osthol/7-Methoxy-8-(3-methyl-2-buten-1-yl)-2H-chromen-2-one
Methanol; Acetontrile; DMSO
396.7±42.0 °C at 760 mmHg
HS Code Reference
Personal Projective Equipment
For Reference Standard and R&D, Not for Human Use Directly.
provides coniferyl ferulate(CAS#:484-12-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
Acetaminophen (APAP) overdose leads to severe hepatotoxicity. Osthole, a natural coumarin found in traditional Chinese medicinal herbs, has therapeutic potential in the treatment of various diseases. In this study, we investigated the effects of osthole against APAP-induced hepatotoxicity in mice. Mice were administered osthole (100 mg·kg-1·d-1, ip) for 3 d, then on the fourth day APAP (300 mg/kg, ip) was co-administered with osthole. The mice were euthanized post-APAP, their serum and livers were collected for analysis. Pretreatment with osthole significantly attenuated APAP-induced hepatocyte necrosis and the increases in ALT and AST activities. Compared with the mice treated with APAP alone, osthole pretreatment significantly reduced serum MDA levels and hepatic H2O2 levels, and improved liver GSH levels and the GSSG-to-GSH ratio. Meanwhile, osthole pretreatment markedly alleviated the APAP-induced up-regulation of inflammatory cytokines in the livers, and inhibited the expression of hepatic cytochrome P450 enzymes, but it increased the expression of hepatic UDP-glucuronosyltransferases (UGTs) and sulfotransferases (SULTs). Furthermore, osthole pretreatment reversed APAP-induced reduction of hepatic cAMP levels, but pretreatment with H89, a potent selective PKA inhibitor, failed to abolish the beneficial effect of osthole, whereas pretreatment with L-buthionine sulfoximine, a GSH synthesis inhibitor, abrogated the protective effects of osthole on APAP-induced liver injury, and abolished osthole-caused alterations in APAP-metabolizing enzymes. In cultured murine primary hepatocytes and Raw264.7 cells, however, osthole (40 μmol/L) did not alleviate APAP-induced cell death, but it significantly suppressed APAP-caused elevation of inflammatory cytokines. Collectively, we have demonstrated that osthole exerts a preventive effect against APAP-induced hepatotoxicity by inhibiting the metabolic activation of APAP and enhancing its clearance through an antioxidation mechanism.
Osthole prevents acetaminophen-induced liver injury in mice.
Cai Y1, Sun W1, Zhang XX1, Lin YD1, Chen H1, Li H1.
Triple-negative breast cancer (TNBC) is an aggressive subgroup of human breast cancer. Patients with TNBC have poor clinical outcome as they are non-responsive to current targeted therapies. There is an urgent need to identify new therapeutic targets and develop more effective treatment options for TNBC patients. Osthole, a natural product from C. monnieri, has been shown to inhibit certain cancer cells. However, the mechanisms of action as well as its effect on TNBC cells are not currently known.
We investigated the effect of osthole in cultured TNBC cells as well as in a xenograft model of TNBC growth. We also used a high-throughput proteomics platform to identify the direct binding protein of osthole.
We found that osthole inhibited the growth of a panel of TNBC cells and induced apoptosis in both cultured cells and TNBC xenografts. We used a high-throughput proteomics platform and identified signal transducer and activator of transcription 3 (STAT3) as a potential binding protein of osthole. We further show that osthole suppressed STAT3 in TNBC cells to inhibit growth and induce apoptosis. Overexpressing STAT3 in TNBC reduced the effectiveness of osthole treatment.
These results provide support for osthole as a potential new therapeutic agent for the management of TNBC. Moreover, our results indicate that STAT3 may be targeted for the development of novel anti-TNBC drugs.
Cell apoptosis; Osthole; STAT3; Triple-negative breast cancer; Xenografts
Osthole inhibits triple negative breast cancer cells by suppressing STAT3.
Dai X1,2, Yin C1,2, Zhang Y3, Guo G2, Zhao C1, Wang O2, Xiang Y2, Zhang X4, Liang G5.
2018 Dec 22
Coumarins are a group of naturally occurring compounds common in the plant world. These substances and their derivatives exhibit a broad range of biological activities. One of the naturally occurring coumarins is osthole, which can most frequently be found in plants of the Apiaceae family. Cnidium monnieri (L.) Cusson ex Juss. Angelica pubescens Maxim. and Peucedanum ostruthium (L.). It has anti-proliferative, anti-inflammatory, anti-convulsant, and antiallergic properties; apart from that, inhibition of platelet aggregation has also been proved. The impact of osthole on bone metabolism has been demonstrated; also its hepatoprotective and neuroprotective properties have been confirmed. The inhibitory effect of this metokcompound on the development of neurodegenerative diseases has been proved in experimental models. Anticancer features of osthole have been also demonstrated both in vitro on different cell lines, and in vivo using animals xenografts. Osthole inhibited proliferation, motility and invasiveness of tumor cells, which may be associated with the induction of apoptosis and cell cycle slowdown. The exact molecular mechanism of osthole anti-cancer mode of action has not been fully elucidated. A synergistic effect of osthole with other anti-tumor substances has been also reported. Modification of its chemical structure led to the synthesis of many derivatives with significant anticancer effects. To sum up, osthole is an interesting therapeutic option, due to both its direct effect on tumor cells, as well as its neuroprotective or anti-inflammatory properties. Thus, there is a chance to use osthole or its synthetic derivatives in the treatment of cancer.
Pharmacological features of osthole.
Jarzab A1, Grabarska A1, Skalicka-Woźniak K2, Stepulak A1.
2017 May 15
Osthole is a natural antihistamine alternative. Osthole may be a potential inhibitor of histamine H1 receptor activity.