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Otophylloside B 4”’-O- beta-D-cymaropyranoside

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PMID

31268626

Abstract

Purpose
To define the clinical characteristics and prognostic value of pre?retreatment plasma Epstein?Barr virus (EBV) DNA, we investigated EBV status in locoregional recurrent nasopharyngeal carcinoma (lrNPC) patients.

Methods
Between April 2008 and August 2016, the data of patients with nonmetastatic lrNPC were retrospectively reviewed. The survival indexes of patients between different pre?retreatment EBV status groups were compared.

Results
A total of 401 patients with nonmetastatic lrNPC were enrolled, and 197 (49.1%) patients had detectable pre?retreatment plasma EBV DNA. Treatment included radiotherapy alone (n = 37 patients), surgery alone (n = 105), radiotherapy (n = 208), surgery combined with radiotherapy (n = 20), chemotherapy and targeted therapy (n = 31). Median follow?up was 32 months. The 3?year locoregional relapse?free survival (LRRFS), distant metastasis?free survival (DMFS), and overall survival (OS) rates for the entire cohort were 64.8%, 89.4%, and 58.8%, respectively. The estimated 3?year LRRFS, DMFS, and OS rates for the pre EBV?positive group vs the pre EBV?negative group were 54.2% vs 75.0% (P < 0.001), 86.6% vs 91.9% (P = 0.05), 51.6% vs 65.9% (P = 0.01), respectively. Among patients in the clinical stage rI/II, there were 17 patients in the radiotherapy alone group and 49 patients in the surgery alone group. And there was no significant difference in overall survival between radiotherapy and surgery, even among the different pre?EBV statuses (P > 0.05). In terms of long?term toxic and side effects, the incidence of radioactive temporal lobe injury in the radiotherapy group was higher than that in the surgery group (35.3% vs 8.2%, P < 0.001), and no statistically significant difference was found in other long?term toxic and side effects. Conclusions The positive rate of pre?retreatment plasma EBV DNA in lrNPC is lower than primary NPC. The prognosis of EBV DNA negative group is better than positive group. For locally early?stage lrNPC, regardless of EBV DNA status, radiotherapy and surgery are available options and both can achieve better long?term survival.

KEYWORDS

clinical characteristics, Epstein?Barr Virus DNA, prognostic, recurrent nasopharynx

Title

Clinical characteristics and prognostic value of pre?retreatment plasma epstein?barr virus DNA in locoregional recurrent nasopharyngeal carcinoma

Author

Ming?Zhu Liu, 1 , 2 , 3 , 4 Shuo?Gui Fang, 1 , 2 , 3 , 4 Wei Huang, 1 , 2 , 3 , 4 Han?Yu Wang, 1 , 2 , 3 , 4 Yun?Ming Tian, 5 Run?Da Huang, 1 , 2 , 3 , 4 Zhuang Sun, 1 , 2 , 3 , 4 Chong Zhao, 1 , 2 , 3 , 4 Tai?Xiang Lu, 1 , 2 , 3 , 4 Ying Huang,corresponding author 1 , 2 , 3 , 4 and Fei Hancorresponding author 1 , 2 , 3 , 4

Publish date

2019 Aug;

PMID

29529162

Abstract

Background
The carbohydrate-to-fiber ratio is a recommended measure of carbohydrate quality; however, its relation to incident coronary heart disease (CHD) is not currently known.

Objective
We aimed to assess the relation between various measures of carbohydrate quality and incident CHD.

Design
Data on diet and lifestyle behaviors were prospectively collected on 75,020 women and 42,865 men participating in the Nurses’ Health Study (NHS) and the Health Professionals Follow-Up Study (HPFS) starting in 1984 and 1986, respectively, and every 2-4 y thereafter until 2012. All participants were free of known diabetes mellitus, cancer, or cardiovascular disease at baseline. Cox proportional hazards regression models were used to assess the relation between dietary measures of carbohydrate quality and incident CHD.

Results
After 1,905,047 (NHS) and 921,975 (HPFS) person-years of follow-up, we identified 7,320 cases of incident CHD. In models adjusted for age, lifestyle behaviors, and dietary variables, the highest quintile of carbohydrate intake was not associated with incident CHD (pooled-RR = 1.04; 95% CI: 0.96, 1.14; P-trend = 0.31). Total fiber intake was not associated with risk of CHD (pooled-RR = 0.94; 95% CI: 0.85, 1.03; P-trend = 0.72), while cereal fiber was associated with a lower risk for incident CHD (pooled-RR = 0.80; 95% CI: 0.74, 0.87; P-trend < 0.0001). In fully adjusted models, the carbohydrate-to-total fiber ratio was not associated with incident CHD (pooled-RR = 1.04; 95% CI: 0.96, 1.13; P-trend = 0.46). However, the carbohydrate-to-cereal fiber ratio and the starch-to-cereal fiber ratio were associated with an increased risk for incident CHD (pooled-RR = 1.20; 95% CI: 1.11, 1.29; P-trend < 0.0001, and pooled-RR = 1.17; 95%CI: 1.09, 1.27; P-trend < 0.0001, respectively). Conclusion Dietary cereal fiber appears to be an important component of carbohydrate quality. The carbohydrate-to-cereal fiber ratio and the starch-to-cereal fiber ratio, but not the carbohydrate-to-fiber ratio, was associated with an increased risk for incident CHD. Future research should focus on how various measures of carbohydrate quality are associated with CHD prevention. This trial was registered at clinicaltrials.gov as NCT03214861.

KEYWORDS

carbohydrates, carbohydrate quality, diet quality, whole grains, type 2 diabetes, starch, fiber

Title

Carbohydrate quality and quantity and risk of coronary heart disease among US women and men

Author

Hala B AlEssa,1 Randy Cohen,5 Vasanti S Malik,1 Sally N Adebamowo,6 Eric B Rimm,1,2,3 JoAnn E Manson,2,4 Walter C Willett,1,2,3 and Frank B Hu1,2,3

Publish date

2018 Feb

PMID

29527452

Abstract

The cyclodextrin glycosyltransferase (CGTase) was used to catalyze the conversion of starch into cyclodextrins (CD) in industry. Improving the activity of CGTase to produce more CD with relative low cost is intensely interesting and has drawn wide attention. Amino acid mutation of His167 into Cys significantly enhanced β-CGTase activity; however, optimization of culture conditions for β-CGTase-H167C remains unclear. To determine this, the medium and culture conditions for β-CGTase-H167C were optimized with response surface methodology. Maximum activity of β-CGTase-H167C was obtained with the medium containing 1.1% corn starch, 4.4% corn steep liquor, 1.1% peptone, 0.02% MgSO4·7H2O and 0.1% K2HPO4·3H2O that were cultured with the initial pH 8.4, incubation temperature at 37.4 °C, with 5% inoculation size and shaking speed at 202 r/min. Under the optimal conditions, the activity of β-CGTase-H167C was up to 4355 U/mL, which is 1.93-fold in comparison with the initial activity. Our results established the promising culture strategy for the production of cyclodextrins by β-CGTase-H167C.

KEYWORDS

β-CGTase, Optimization, Medium components, Culture conditions, Cyclodextrins

Title

Optimization of the fermentation conditions for the mutant strain of β-cyclodextrin glycosyltransferase H167C to produce cyclodextrins

Author

Hua Wang,corresponding author1 Wenxi Zhou,2 Hua Li,1 and Rie Bu1

Publish date

2018 Mar;