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p-Hydroxybenzoic acid

$52

  • Brand : BIOFRON

  • Catalogue Number : BD-P0230

  • Specification : 98.0%(HPLC)

  • CAS number : 99-96-7

  • PUBCHEM ID : 135

  • Volume : 100mg

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Catalogue Number

BD-P0230

Analysis Method

HPLC,NMR,MS

Specification

98.0%(HPLC)

Storage

2-8°C

Molecular Weight

Appearance

White crystal

Botanical Source

" Isol. from many plants, free and combined. First isol. from fruits of Catalpa bignonioides"

Structure Type

Simple Phenolic Compounds

Category

Standards;Natural Pytochemical;API

SMILES

C1=CC(=CC=C1C(=O)O)O

Synonyms

4-Hydroxybenzoicacid/Benzoic acid,4-hydroxy/PARAHYDROXY BENZOIC ACID/4-HYDROXYBENZOIC ACID FOR SYNTHESIS/4-Hydroxybenzoic acid/p-Salicylic acid/4-Hydroxy benzoic acid/HYDROXYBENZOIC ACID, P- POLYMER GRADE/|p|-Hydroxybenzoic acid/4-Hydroxybenzoesaeure/Benzoic acid,p-hydroxy/P-HYDROXYBENZOIC ACID, REAGENT/PROPYL PARAHYDROXYBENZOATE IMP. A (EP): 4-HYDROXYBENZOIC ACID, CRM STANDARD/ACETYLSALICYLIC ACID IMPURITY A (ASPIRIN IMPURITY A)/1-Naphthyl phsophoric acid sodium salt/4-Carboxyphenol/p-Hydroxybenzoic acid/para-Hydroxybenzoic acid/4-hydroxy-benzoic acid/papa-hydroxy-benzoic acid/p-carboxyphenol

IUPAC Name

4-hydroxybenzoic acid

Applications

4-Hydroxybenzoic acid, a phenolic derivative of benzoic acid, could inhibit most gram-positive and some gram-negative bacteria, with an IC50 of 160 μg/mL.

Density

1.4±0.1 g/cm3

Solubility

Methanol

Flash Point

171.3±19.7 °C

Boiling Point

336.2±25.0 °C at 760 mmHg

Melting Point

213-217 °C(lit.)

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2918290000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:99-96-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

28324514

Abstract

Biotransformation of p-coumaric acid by Paecilomyces variotii resulted in the accumulation of a metabolite which was identified as p-hydroxybenzoic acid. We studied the possibility of enhancing this metabolite by various parameters such as varying the concentration of substrate, addition of different nitrogen sources and carbon sources at varying concentration and use of different agricultural wastes as a nutritive medium. Maximum amount of 254.6 ± 9.34 mg/kg of p-hydroxybenzoic acid was detected in the solid medium of corncob on 4th day of incubation using 10 mM p-coumaric acid as a sole carbon source. Consequently, P. variotii can be used as candidate fungi for the production of p-hydroxybenzoic acid. Solid wastes can be managed by using them for biotransformation of pharmaceutically important phenolic acids and hence cut down the cost of production of value-added compounds using a low-cost medium.

KEYWORDS

Biotransformation; Corncob; HPLC; p-Coumaric acid; p-Hydroxybenzoic acid

Title

Standardization of medium composition and agricultural waste in the production of p-hydroxybenzoic acid by Paecilomyces variotii.

Author

Jain JR1, John JT1, Jyotirmoy G2, Manohar SH3,4.

Publish date

2015 Oct

PMID

16292647

Abstract

In a culture medium of Streptomyces caeruleus MTCC 6638 grown with p-coumaric acid (5 mM) as the sole source of carbon, co-production of caffeic acid and p-hydroxybenzoic acid was observed. Both caffeic acid and p-hydroxybenzoic acid are important phenolic compounds with pharmaceutical importance. These biotransformed products were identified by high-performance liquid chromatography and electrospray ionization mass spectrometry. Obtained data suggest that p-coumaric acid was possibly utilized by two different routes, resulting in the formation of a hydroxycinnamate and a hydroxybenzoate compound. However, higher concentration of p-coumaric acid (10 mM) favoured caffeic acid formation. Addition of 5 mM p-coumaric acid into S. caeruleus cultures pre-grown on minimal medium with 1.0 g/l glucose resulted in the production of 65 mg/l caffeic acid. Furthermore, S. caeruleus cells were able to produce the maximum amount of caffeic acid when pre-grown on nutrient broth for 16 h. Under this condition, the addition of 5 mM p-coumaric acid was sufficient for the S. caeruleus culture to produce 150 mg/l caffeic acid, with a molar yield of 16.6% after 96 h of incubation.

Title

Co-production of caffeic acid and p-hydroxybenzoic acid from p-coumaric acid by Streptomyces caeruleus MTCC 6638.

Author

Sachan A1, Ghosh S, Sen SK, Mitra A.

Publish date

2006 Aug

PMID

31123227

Abstract

This paper is built on the Fenton-like oxidation of p-hydroxybenzoic acid (p-HBZ) in the presence of H2O2 and 3%Fe supported on CeO2-TiO2 aerogels under mild conditions. These catalysts were deeply characterized by X-ray diffraction (XRD), hydrogen temperature programmed reduction (H2-TPR), transmission electron microscopy (TEM), scanning transmission electron microscopy (STEM) and X-ray photoelectron spectroscopy (XPS). The effect of thermal treatment, pH (2-3, 5, 7), H2O2/p-HBZ molar ratio (5, 15, 20, 25) and reaction temperature (25 °C, 40 °C and 60 °C) on the catalytic properties of supported Fe catalysts are studied. Our results highlight the role of CeO2 and the calcination of the catalyst to obtain the highest catalytic properties after 10 min: 73% of p-HBZ conversion and 52% of total organic carbon (TOC) abatement.

Title

Heterogeneous Fenton-like oxidation of p-hydroxybenzoic acid using Fe/CeO2-TiO2 catalyst.

Author

Hammedi T1, Triki M2, Alvarez MG3, Llorca J4, Ghorbel A5, Ksibi Z5, Medina F3.

Publish date

2019 Apr