We Offer Worldwide Shipping
Login Wishlist

p-Hydroxybenzyl alcohol

$43

  • Brand : BIOFRON

  • Catalogue Number : BF-P2022

  • Specification : 98%

  • CAS number : 623-05-2

  • Formula : C7H8O2

  • Molecular Weight : 124.14

  • PUBCHEM ID : 125

  • Volume : 20mg

In stock

Quantity
Checkout Bulk Order?

Catalogue Number

BF-P2022

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

124.14

Appearance

White crystalline powder

Botanical Source

herbs of Cistanche deserticola Ma

Structure Type

Phenolics

Category

Standards;Natural Pytochemical;API

SMILES

C1=CC(=CC=C1CO)O

Synonyms

4-(Hydroxymethyl)benzolol/(4-Hydroxyphenyl)methanol/Gastrodigenin/p-Methylolphenol/4-hydroxymethyl-phenol/PARA-ALCOHOLPHENOL/4-Hydroxybenzyl alcohol/4-hydroxybenzyl-alcohol/Benzyl alcohol, p-hydroxy- (8CI)/p-(Hydroxymethyl)phenol/p-Hydroxybenzyl/4-(Hydroxymethyl)phenol/RARECHEM AL BD 0098/Benzenemethanol, 4-hydroxy-/Benzyl alcohol, p-hydroxy-/4-METHYLOLPHENOL/benzyl alcohol, 4-hydroxy-/P-HYDROXYBENZYL ALCOHOL/4-HYDROXY-BENZYL-ALCOHOL/α-Hydroxy-p-cresol/Bisoprolol Impurity 19

IUPAC Name

4-(hydroxymethyl)phenol

Density

1.2±0.1 g/cm3

Solubility

Methanol; DMSO

Flash Point

145.8±15.0 °C

Boiling Point

252.0±0.0 °C at 760 mmHg

Melting Point

114-122 °C(lit.)

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2907290000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:623-05-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

30273962

Abstract

Recently, antiobesity studies using the method of inhibiting enzymatic activity of obesity-related enzymes as targets have received considerable attention. The aims of the current study were to investigate whether p-hydroxybenzyl alcohol (HBA), identified from Cudrania tricuspidata fruits with antiobesity effects, inhibits the activity of digestive and obesity-related enzymes and acts as an inhibitor against four target enzymes in kinetic studies. In vitro enzyme assays showed HBA at the highest concentration significantly reduced the enzymatic activity of four targets: pancreatic lipase (IC50 = 2.34-3.70 μM), α-glycosidase (IC50 = 9.08 μM), phosphodiesterase IV (IC50 = 4.99 μM), and citrate synthase (IC50 = 2.07 μM) enzymes. Based on the results of kinetic assays, the types of inhibition were investigated. Our findings indicate that HBA could have antiobesity efficacy, and it deserves further study.

© 2018 Wiley Periodicals, Inc.

KEYWORDS

adipogenesis; obesity; obesity-related enzymes; p-hydroxybenzyl alcohol ( p-HBA)

Title

p-Hydroxybenzyl alcohol inhibits four obesity-related enzymes in vitro.

Author

Choi JH1, Yeo SH2, Kim MK3, Lee HJ1, Kim S1.

Publish date

2018 Dec

PMID

30776009

Abstract

p-hydroxybenzyl alcohol (HBA) is one of the major components of Gastrodia elata Blume (GEB) phenolic compound. HBA has been reported to have a protective effect on amyloid-β (Aβ) induced cell death. However, the systemic effects and the detail molecular mechanism of HBA in Alzheimer’s disease (AD) animal models is not clear. In this study, we revealed the protective effects and the potential mechanisms of HBA on the impairments of cognitive function induced by soluble Aβ oligomers. Our results showed that HBA prevented neuronal cells death in a dose-dependent manner. The working memory and the spatial memory were significantly lower in AD model mice. HBA treatment prevented the memory deficits of the AD mice. HBA treatment significantly prevented the decreased spine density and decreased expression levels of synaptic proteins induced by Aβ42. In addition, both mRNA levels and protein levels of brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) in the Aβ42-treated mice were decreased, the decreases were prevented by HBA treatment. The expression levels of TNF-α and IL-1β were increased by Aβ42 treatment and the increase can be prevented by the HBA treatment. Moreover, HBA prevents the decreases in the level of nuclear erythroid 2 p45-related factor 2 (Nrf2) induced by Aβ42 in hippocampal. Thus, we predict that HBA might prevent Aβ42 oligomer-induced synapse and cognitive impairments through multiple targets including increasing Nrf2, increasing neurotrophic factors and decreasing inflammatory factors. Our study provided novel insights into the cellular mechanisms for the protective effects of HBA on AD.

KEYWORDS

Alzheimer’s disease; brain-derived neurotrophic factor; glial cell line-derived neurotrophic factor; inflammatory factors; memory deficits; nuclear erythroid 2 p45-related factor 2; p-hydroxybenzyl alcohol

Title

p-Hydroxybenzyl Alcohol Prevents Memory Deficits by Increasing Neurotrophic Factors and Decreasing Inflammatory Factors in a Mice Model of Alzheimer's Disease.

Author

Ding Y1, Bao X2, Lao L1, Ling Y1, Wang Q1, Xu S1.

Publish date

2019

PMID

25913862

Abstract

In recent years, the hydroxyalkylphenols p-hydroxybenzyl alcohol and tyrosol, and the compound phloretin and its derivate phloridzin have been described as inhibitors of the enzyme tyrosinase. When the monophenolase and the diphenolase activities of tyrosinase on its physiological substrates l-dopa and/or l-tyrosine are measured in the presence of these compounds, the rate of action of the enzyme decreases. These findings led to the identification of these compounds as inhibitors. However, these molecules show an unusual behavior as inhibitors of the enzyme indeed, in this study, we demonstrate that they are not true inhibitors but alternative substrates of the enzyme.

Copyright © 2015 Elsevier Ltd. All rights reserved.

KEYWORDS

Alternative substrate; Phloretin; Phloridzin; Tyrosinase; Tyrosol; p-Hydroxybenzyl alcohol

Title

Identification of p-hydroxybenzyl alcohol, tyrosol, phloretin and its derivate phloridzin as tyrosinase substrates.

Author

Ortiz-Ruiz CV1, Berna J2, Garcia-Molina Mdel M1, Tudela J1, Tomas V3, Garcia-Canovas F4.

Publish date

2015 Jul 1


Description :

4-Hydroxybenzyl alcohol is a phenolic compound widely distributed in various kinds of plants. Anti-inflammatory, anti-oxidant, anti-nociceptive activity. Neuroprotective effect. Inhibitor of tumor angiogenesis and growth[1][2][3][4].