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p-Nitrohydrocinnamic acid

$96

  • Brand : BIOFRON

  • Catalogue Number : BN-O1015

  • Specification : 98%(HPLC)

  • CAS number : 16642-79-8

  • Formula : C9H9NO4

  • Molecular Weight : 195.17

  • PUBCHEM ID : 85526

  • Volume : 5mg

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Catalogue Number

BN-O1015

Analysis Method

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

195.17

Appearance

Botanical Source

Structure Type

Category

SMILES

C1=CC(=CC=C1CCC(=O)O)[N+](=O)[O-]

Synonyms

3-(4-Nitrophenyl)propionic acid/Benzenepropanoic acid, 4-nitro-/4-Nitrohydrocinnamic Acid/4-nitrobenzenepropanoic acid/WNR D2VQ/4-nitrophenylpropionic acid/para-nitrohydrocinnamic acid/3-(4-Nitrophenyl)propanoic acid

IUPAC Name

3-(4-nitrophenyl)propanoic acid

Density

1.3±0.1 g/cm3

Solubility

Flash Point

170.5±9.4 °C

Boiling Point

382.7±17.0 °C at 760 mmHg

Melting Point

167-170°C

InChl

InChI=1S/C13H15NO2/c15-12-7-9-4-5-10-8-13(9,16-12)11-3-1-2-6-14(10)11/h4-5,7,10-11H,1-3,6,8H2

InChl Key

VZOPVJNBOQOLPN-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:16642-79-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

28186965

Abstract

As conventional biomarkers for defining breast cancer (BC) subtypes are not always capable of predicting prognosis, search for new biomarkers which can be easily detected by liquid biopsy is ongoing. It has long been known that cell-free DNA (CF-DNA) could be a promising diagnostic and prognostic marker in different tumor types, although its prognostic value in BC is yet to be confirmed. This retrospective study evaluated the prognostic role of CF-DNA quantity and integrity of HER2, MYC, BCAS1 and PI3KCA, which are frequently altered in BC. We collected 79 serum samples before surgery from women at first diagnosis of BC at Forlì Hospital (Italy) from 2002 to 2010. Twenty-one relapsed and 58 non-relapsed patients were matched by subtype and age. Blood samples were also collected from 10 healthy donors. All samples were analyzed by Real Time PCR for CF-DNA quantity and integrity of all oncogenes. Except for MYC, BC patients showed significantly higher median values of CF-DNA quantity (ng) than healthy controls, who had higher integrity and lower apoptotic index. A difference nearing statistical significance was observed for HER2 short CF-DNA (p = 0.078, AUC value: 0.6305). HER2 short CF-DNA showed an odds ratio of 1.39 for disease recurrence with p = 0.056 (95% CI 0.991-1.973). Our study suggests that CF-DNA detected as liquid biopsy could have great potential in clinical practice once demonstration of its clinical validity and utility has been provided by prospective studies with robust assays.

KEYWORDS

CF-DNA, HER2, PI3KCA, prognosis, breast cancer subtypes

Title

Cell-free DNA detected by “liquid biopsy” as a potential prognostic biomarker in early breast cancer

Author

Roberta Maltoni,1 Valentina Casadio,#2 Sara Ravaioli,#2 Flavia Foca,3 Maria Maddalena Tumedei,2 Samanta Salvi,2 Filippo Martignano,2 Daniele Calistri,2 Andrea Rocca,1 Alessio Schirone,1 Dino Amadori,1 and Sara Bravaccini2

Publish date

2017 Mar 7

PMID

30978947

Abstract

Mulberry fruit (Morus alba L.) contains abundant bioactive compounds, including anthocyanins and flavonols, and has been reported to possess potent beneficial properties including anticancer, antidiabetic, and anti-oxidant effects. High hydrostatic pressure (HHP) processing, a nonthermal food processing technology, is suitable for the extraction of bioactive compounds from plants. Nevertheless, the anti-inflammatory effects of HHP extract of mulberry fruit (HM) in RAW264.7 cells remain unclear. The present study aimed to investigate the anti-inflammatory effects of HM on lipopolysaccharide (LPS)-induced inflammation in vitro. RAW264.7 cells were treated with various concentrations (0.1-1 μg/mL) of HM in the presence or absence of LPS. HM inhibited the inflammatory mediator, nitric oxide (NO) release, and mRNA expression of nitric oxide synthase 2 (NOS2) in LPS-induced RAW264.7 cells. In addition, HM suppressed both mRNA and protein expressions of prostaglandin-endoperoxide synthase 2 (PTGS2). Moreover, it reduced the LPS-induced secretion of proinflammatory cytokines such as interleukin (IL)-6 and tumor necrosis factor (TNF)-α. These results revealed that HM exerts anti-inflammatory effects by inhibiting several mediators and cytokines involved in the inflammatory process.

KEYWORDS

mulberry fruit, high hydrostatic pressure, macrophage, inflammation

Title

Anti-Inflammatory Effects of High Hydrostatic Pressure Extract of Mulberry (Morus alba) Fruit on LPS-Stimulated RAW264.7 Cells

Author

Sunyoon Jung,1 Mak-Soon Lee,1 Ae-Jin Choi,2 Chong-Tai Kim,3 and Yangha Kim1,

Publish date

2019 Apr;

PMID

28377387

Abstract

Objective
Recent evidence suggests that antibiotic use, which alters the gut microbiome, is associated with an increased risk of colorectal cancer. However, the association between antibiotic use and risk of colorectal adenoma, the precursor for the majority of colorectal cancers, has not been investigated.

Design
We prospectively evaluated the association between antibiotic use at age 20-39 and 40-59 (assessed in 2004) and recent antibiotic use (assessed in 2008) with risk of subsequent colorectal adenoma among 16,642 women aged ≥60 enrolled in the Nurses’ Health Study who underwent at least one colonoscopy through 2010. We used multivariate logistic regression to calculate odds ratios (ORs) and 95% confidence intervals (CIs).

Results
We documented 1,195 cases of adenoma. Increasing duration of antibiotic use at age 20-39 (Ptrend=0.002) and 40-59 (Ptrend=0.001) was significantly associated with an increased risk of colorectal adenoma. Compared to non-users, women who used antibiotics for ≥2 months between age 20-39 had a multivariable OR of 1.36 (95% CI: 1.03-1.79). Women who used ≥2 months of antibiotics between age 40-59 had a multivariable OR of 1.69 (95% CI: 1.24-2.31). The associations were similar for low-risk vs. high-risk adenomas (size ≥1 cm, or with tubulovillous/villous histology, or ≥3 detected lesions), but appeared modestly stronger for proximal compared with distal adenomas. In contrast, recent antibiotic use within the past 4 years was not associated with risk of adenoma (Ptrend=0.44).

Conclusions
Long-term antibiotic use in early to middle adulthood was associated with increased risk of colorectal adenoma.

KEYWORDS

antibiotics, colorectal adenomas, colonic microflora

Title

Long-term use of antibiotics and risk of colorectal adenoma

Author

Yin Cao,1,2,3 Kana Wu,3 Raaj Mehta,1,2 David A. Drew,1,2 Mingyang Song,1,2,3 Paul Lochhead,1,2 Long H. Nguyen,1,2 Jacques Izard,4 Charles S. Fuchs,5,6,7 Wendy S. Garrett,9,10,11 Curtis Huttenhower,10,12 Shuji Ogino,9,13,14 Edward L. Giovannucci,3,8,13 and Andrew T. Chan1,2,8,10

Publish date

2019 Apr 1.


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