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Paeonol

$43

  • Brand : BIOFRON

  • Catalogue Number : BF-P1004

  • Specification : 98%

  • CAS number : 552-41-0

  • Formula : C9H10O3

  • Molecular Weight : 166.18

  • PUBCHEM ID : 11092

  • Volume : 20mg

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Catalogue Number

BF-P1004

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

166.18

Appearance

White crystalline powder/Paeonia moutan, Xanthorrhoea arborea, Xanthorrhoea reflexa, Betula platyplylla, Paeonia suffruticosa, Exacum affine, Arisaema erubescens, Dioscorea japonica, Primula auricula and other plants

Botanical Source

Paeonia suffruticosa,Trichosanthes kirilowii,Cynanchum paniculatum,Ampelopsis japonica,Eleutherococcus brachypus

Structure Type

Phenolics

Category

Standards;Natural Pytochemical;API

SMILES

CC(=O)C1=C(C=C(C=C1)OC)O

Synonyms

1-(2-Hydroxy-4-methoxyphenyl)ethanone/2-Acetyl-5-methoxy-phenol/2-Hydroxy-4-methoxyacetophenone/Acetophenone, 2'-hydroxy-4'-methoxy-/Ethanone, 1- (2-hydroxy-4-methoxyphenyl)-/2'-hydroxy-4'-methoxyacetophenone/4-Methoxy-2-hydroxyacetophenone/Paeonol/Ethanone, 1-(2-hydroxy-4-methoxyphenyl)-/1-(2-Hydroxy-4-methoxyphenyl)ethan-1-one

IUPAC Name

1-(2-hydroxy-4-methoxyphenyl)ethanone

Density

1.2±0.1 g/cm3

Solubility

Methanol; Chloroform; Ethyl Acetate

Flash Point

122.3±15.8 °C

Boiling Point

301.9±22.0 °C at 760 mmHg

Melting Point

48-50 °C(lit.)

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2914500000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:552-41-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

31872593

Abstract

To prepare Helix aspersa muller-paeonol nanogel( PAE-HAM-Gels) with anti-proliferative scar effect,evaluate its skin penetration,retention and irritation,and to investigate its prevention and treatment effect for hypertrophic scar in rabbit ears. The dermal retention,transdermal rate and cumulative permeability of paeonol were investigated in vitro by using the modified Franz diffusion cell and the abdominal skin of suckling pigs,SD rats and KM mice,respectively,and the in vitro permeation curves were drawn. The normal skin of the back of New Zealand rabbits was continuously treated with PAE-HAM-Gels for 7 days,and the physiological state of the skin was observed under light microscope after HE staining by using homologous left and right contrast method. The hypertrophic scar model in rabbit ears was established,and the New Zealand rabbits were randomly divided into blank group,model group,positive drug group,PAE-Gels group and PAE-HAM-Gels group. After 28 days of administration,the scar hyperplasia rate and scar elevation index( SEI) of each group were calculated; the scar tissues were taken and stained with Masson for observation of collagen fibers and muscle fibers hyperplasia under light microscope,and the expression level of TGF-β1 in each group was detected. The Qnof PAE-HAM-Gels in aqueous solution was in line with the Higuchi equation,and its transdermal rate,cumulative permeation and dermal retention in different animal skins were all higher than those of PAE-Gels. The skin of the drug-administered group was intact,without erythema,edema or other phenomena; under light microscope,the subcutaneous tissue and the epidermal cells were neatly arranged with uniform thickness,which showed no difference from the blank group. The scar hyperplasia rate of the PAE-HAM-Gels group was 62. 50%; SEI was 2. 17±0. 33 and TGF-β1 was( 815. 4±34. 69) ng·L~(-1),significantly different from those in model group( P<0. 01). Masson staining showed that as compared with the model group,the number of collagen fibers and muscle fibers was small and the arrangement was loose and tidy in the PAE-HAM-Gels group,with regular arrangement of chondrocytes and a small number of inflammatory cells and microvessels.PAE-HAM-Gels have good transdermal properties and dermal retention without skin irritation,offering a promising therapeutic strategy for transdermal delivery during the prevention and treatment of hypertrophic scar in rabbit ears.

KEYWORDS

Helix aspersa muller; TGF-β1; hypertrophic scar; nanoparticle; paeonol

Title

[Study on physicochemical properties of paeonol-Helix aspersa muller nanogel and its inhibitory effects on hypertrophic scar tissue in rabbit ear].

Author

Guo SY1, Chen GT1, Shi J2, Wu YT1, Lai JH1, Xu XQ1.

Publish date

2019 Nov

PMID

31407455

Abstract

Moutan Cortex has been widely used to treat various types of arthritis in traditional Chinese medicine. Paeonol is isolated as an active ingredient from Moutan Cortex. However, the effect and potential mechanism of paeonol on gouty arthritis have not been evaluated. In this study, rats were treated intragastrically with paeonol for consecutive 7 days. On Day 5, rats were intra-articularly injected with monosodium urate (MSU) crystals in the ankle joints to induce MSU-induced arthritis (MIA). Paw volume was detected at various time points. Gait score was measured at 24 hr after MSU crystal injection. Ankle joints were collected for evaluation of histological score and expression of proinflammatory cytokines using hematoxylin and eosin staining and immunohistochemistry staining, respectively. Nuclear level of nuclear factor (NF)-κBp65 in synovial tissues was analyzed by western blot assay. NF-κB DNA-binding activity was measured by enzyme linked immunosorbent assay. Paeonol markedly lowered the paw volume, gait score, and histological score in MIA rats. Mechanistically, paeonol markedly reduced the expression of TNF-α, IL-1β, and IL-6 in synovial tissues of MIA rats. In addition, the elevated level of p65 in nucleus and NF-κB DNA-binding activity in synovial tissues of MIA rats were reduced significantly by paeonol treatment. These findings suggest that paeonol exerts anti-inflammatory effect in MIA rats through inhibiting expression of proinflammatory cytokines and NF-κB activation.

© 2019 John Wiley & Sons, Ltd.

KEYWORDS

MSU-induced arthritis; NF-κB; paeonol; proinflammatory cytokines

Title

Paeonol ameliorates monosodium urate-induced arthritis in rats through inhibiting nuclear factor-κB-mediated proinflammatory cytokine production.

Author

Chen G1, Jia P2, Yin ZY1, Kong SZ1, Xiang ZB1, Zheng XX1.

Publish date

2019 Nov

PMID

31382644

Abstract

Radiation-induced oral mucositis represents an influential factor in cancer patients’ accepted radiation therapy, especially in head and neck cancer. This research investigates the treatment effect of Ecdysterone (a steroid derived from the dry root of Achyranthes bidentate) and Paeonol (a compound derived from Cortex Moutan) on radiation-induced oral mucositis and possible underlying mechanisms. Concisely, 20 Gy of X-rays (single-dose) irradiated the cranial localization in rats for the modeling of oral mucositis. The therapeutic effects of Ecdysterone-Paeonol oral cavity directly administered on radiation-induced oral mucositis were investigated by weight changes, direct observations, visual scoring methods, ulcer area/total area, and basic recovery days. Assessments of tumor necrosis factor α and interleukin-6 were performed to evaluate the inflammatory cytokines secretion in the damaged areas of tongues harvested post-treatment, and changes in signaling pathways were investigated by Western blotting. System Drug Target (SysDT) methods revealed the targets of Ecdysterone-Paeonol in order to support compound-target network construction. Four representative targets with different functions were chosen. The binding interactions between the compound and receptor were evaluated by molecular docking to investigate the binding affinity of the ligand to their protein targets. Ecdysterone-Paeonol, administered orally, effectively improved radiation-induced oral mucositis in rats, and the therapeutic effect was better than Ecdysterone administered orally on its own. In this study, calculational chemistry revealed that Ecdysterone-Paeonol affected 19 function targets associated with radiation-induced oral mucositis, including apoptosis, proliferation, inflammation, and wound healing. These findings position Ecdysterone-Paeonol as a potential treatment candidate for oral mucositis acting on multiple targets in the clinic.

KEYWORDS

autodock; compound-target network; ecdysterone-paeonol; oral cavity direct administered; radiation-induced oral mucositis; therapeutic effect

Title

Therapeutic Effect of Ecdysterone Combine Paeonol Oral Cavity Direct Administered on Radiation-Induced Oral Mucositis in Rats.

Author

Yang L1, Pan J2.

Publish date

2019 Aug


Description :

Paeonol is an active extraction from the root of Paeonia suffruticosa, Paeonol inhibits MAO-A and MAO-B with IC50 of 54.6 μM and 42.5 μM, respectively.