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Palmatine hydrochloride

$43

  • Brand : BIOFRON

  • Catalogue Number : BF-P2015

  • Specification : 98%

  • CAS number : 10605-02-4

  • Formula : C21H22ClNO4

  • Molecular Weight : 387.86

  • PUBCHEM ID : 73442

  • Volume : 20mg

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Catalogue Number

BF-P2015

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

387.86

Appearance

Powder

Botanical Source

rhizomes of Coptis chinensis Franch.

Structure Type

Alkaloids

Category

Standards;Natural Pytochemical;API

SMILES

COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(C=C4CC3)OC)OC)OC.[Cl-]

Synonyms

Dibenzo[a,g]quinolizinium, 5,6-dihydro-2,3,9,10-tetramethoxy-, chloride (1:1)/Palmatine chloride/GNF-PF-4086/2,3,9,10-Tetramethoxy-5,6-dihydroisoquinolino[3,2-a]isoquinolinium chloride/Palmatine chloride,Palmatine hydrochloride/Palmatinehydrochloride/2,3,9,10-Tetramethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium chloride/Prestwick_374/Palmatine (chloride)

IUPAC Name

2,3,9,10-tetramethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium;chloride

Density

Solubility

Methanol

Flash Point

Boiling Point

Melting Point

InChl

InChI=1S/C21H22NO4.ClH/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4;/h5-6,9-12H,7-8H2,1-4H3;1H/q+1;/p-1

InChl Key

RLQYRXCUPVKSAW-UHFFFAOYSA-M

WGK Germany

RID/ADR

HS Code Reference

2939790000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:10605-02-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

31685744

Abstract

Phellodendron bark (“Obaku”) is an important crude drug used in Kampo-medicine. Recently, powder formulation of phellodendron bark was approved as an “efficacious treatment for bruise, sprain, and periodontal diseases”, and it has been marketed as an OTC agent. To obtain this approval, the examination of quality control-related characteristics is necessary. Therefore, we established a quantitative method for jatrorrhizine, palmatine, and berberine determination. In this study, we compared the contents of the three constituents obtained from the extracts of Japanese and Chinese phellodendron bark and found remarkable difference.

KEYWORDS

berberine; jatrorrhizine; palmatine; powdered phellodendron bark formulation

Title

[Simultaneous Quantitative Analysis of Berberine and Other Alkaloids in Powdered Phellodendron Bark].

Author

Kamimura S1, Nishihara M1, Osumi Y1, Shiota H1.

Publish date

2019;

PMID

31482933

Abstract

Depurination occurs via hydrolysis of the purine-deoxyribose glycosyl bond and causes nucleic acid damage. In particular, the DNA sequences that can undergo a self-catalyzed depurination (SCD) will cause a great uncertainty in duplicating, separating, purifying, and storing the DNA samples. Therefore, there is a great demand to develop a rapid detection method for SCD events. Herein, the use of a convenient fluorescence method to follow the site-specific SCD was demonstrated. We found that the resultant apurine site (AP site) from depurination can be selectively recognized by a fluorescent probe of palmatine (PAL) with a turn-on fluorescence response. The dependence of SCD on the bases of the depurination site, pH, metal ions, and time shows that our method can be used to rapidly evaluate the depurination process. Furthermore, the depurination process can be photo-switched using a photoacid as an external initiator. Our work will find wide applications in preliminarily identifying the DNA depurination.

Title

Fluorescently probing site-specific and self-catalyzed DNA depurination.

Author

Fei Y1, Yan C1, Yu Y1, Gao L1, Ye T1, Zhang Q1, Gao H1, Zhou X1, Shao Y1.

Publish date

2019 Oct 7;

PMID

31462179

Abstract

A natural isoquinoline alkaloid, berberine, has been known to exhibit anti-tumor activity in various cancer cells via inducing cell cycle arrest. However, it has not been investigated whether berberine and its analogs inhibit the growth of rhabdomyosarcoma (RMS), which is the most frequent soft tissue tumor in children. The present study examined the anti-tumor effects of berberine and palmatine on expansions of three human embryonal RMS cell lines; ERMS1, KYM1, and RD. Intracellular incorporation of berberine was relatively higher than that of palmatine in every RMS cell line. Berberine significantly inhibited the cell cycle of all RMS cells at G1 phase. On the other hand, palmatine only suppressed the growth of RD cells. Both of berberine and palmatine strongly inhibited the growth of tumorsphere of RD cells in three-dimensional culture. These results indicate that berberine derivatives have the potential of anti-tumor drugs for RMS therapy.Abbreviations: ARMS: alveolar rhabdomyosarcoma; ERMS: embryonal rhabdomyosarcoma; RMS: rhabdomyosarcoma.

KEYWORDS

Berberine; palmatine; rhabdomyosarcoma; three-dimensional culture; tumorsphere

Title

Berberine and palmatine inhibit the growth of human rhabdomyosarcoma cells.

Author

Shinji S1, Nakamura S1, Nihashi Y2, Umezawa K3, Takaya T1,2,3.

Publish date

2020 Jan


Description :

Palmatine chloride an isoquinoline alkaloid, is an important medicinal herbal extract with diverse pharmacological and biological properties. IC50 value:Target:In vitro: Experimental set examined the influence of palmatine on osteoblast-like cells in vitro. In the culture supernatant of MC3T3-E1 cells, RANKL and OPG levels were significantly reduced by palmatine addition [1]. In vivo: The first experimentaI set was designed to histologically and biochemically examine mice randomly divided into four groups: sham-operated, OVX, and OVX-palmatine intake groups (1 mg/kg and 10 mg/kg). In palmatine-treated mice, RANKL and OPG expression decreased [1].