White crystalline powder/Yellow powder
rhizomes of Coptis chinensis Franch.
Calystigine/7,8,13,13a-tetradehydro-2,3,9,10-tetramethoxyberbinium/palmatine/Burasaine/2,3,9,10-tetramethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium/2,3,9,10-Tetramethoxy-5,6-dihydroisoquinolino[3,2-a]isoquinolinium/palmatin/berbericinine/7,8,13,13a-tetrahydro-2,3,9,10-tetramethoxyberbinium/Dibenzo[a,g]quinolizinium, 5,6-dihydro-2,3,9,10-tetramethoxy-/o,o-dimethyldemethyleneberberine/Hindarinine/5,6-Dihydro-2,3,9,10-tetramethoxy-dibenzo[a,g]quinolizinium/Common fibraurea stem
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provides coniferyl ferulate(CAS#:3486-67-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
Phellodendron bark (“Obaku”) is an important crude drug used in Kampo-medicine. Recently, powder formulation of phellodendron bark was approved as an “efficacious treatment for bruise, sprain, and periodontal diseases”, and it has been marketed as an OTC agent. To obtain this approval, the examination of quality control-related characteristics is necessary. Therefore, we established a quantitative method for jatrorrhizine, palmatine, and berberine determination. In this study, we compared the contents of the three constituents obtained from the extracts of Japanese and Chinese phellodendron bark and found remarkable difference.
berberine; jatrorrhizine; palmatine; powdered phellodendron bark formulation
[Simultaneous Quantitative Analysis of Berberine and Other Alkaloids in Powdered Phellodendron Bark].
Kamimura S1, Nishihara M1, Osumi Y1, Shiota H1.
Depurination occurs via hydrolysis of the purine-deoxyribose glycosyl bond and causes nucleic acid damage. In particular, the DNA sequences that can undergo a self-catalyzed depurination (SCD) will cause a great uncertainty in duplicating, separating, purifying, and storing the DNA samples. Therefore, there is a great demand to develop a rapid detection method for SCD events. Herein, the use of a convenient fluorescence method to follow the site-specific SCD was demonstrated. We found that the resultant apurine site (AP site) from depurination can be selectively recognized by a fluorescent probe of palmatine (PAL) with a turn-on fluorescence response. The dependence of SCD on the bases of the depurination site, pH, metal ions, and time shows that our method can be used to rapidly evaluate the depurination process. Furthermore, the depurination process can be photo-switched using a photoacid as an external initiator. Our work will find wide applications in preliminarily identifying the DNA depurination.
Fluorescently probing site-specific and self-catalyzed DNA depurination.
Fei Y1, Yan C1, Yu Y1, Gao L1, Ye T1, Zhang Q1, Gao H1, Zhou X1, Shao Y1.
2019 Oct 7
A natural isoquinoline alkaloid, berberine, has been known to exhibit anti-tumor activity in various cancer cells via inducing cell cycle arrest. However, it has not been investigated whether berberine and its analogs inhibit the growth of rhabdomyosarcoma (RMS), which is the most frequent soft tissue tumor in children. The present study examined the anti-tumor effects of berberine and palmatine on expansions of three human embryonal RMS cell lines; ERMS1, KYM1, and RD. Intracellular incorporation of berberine was relatively higher than that of palmatine in every RMS cell line. Berberine significantly inhibited the cell cycle of all RMS cells at G1 phase. On the other hand, palmatine only suppressed the growth of RD cells. Both of berberine and palmatine strongly inhibited the growth of tumorsphere of RD cells in three-dimensional culture. These results indicate that berberine derivatives have the potential of anti-tumor drugs for RMS therapy.Abbreviations: ARMS: alveolar rhabdomyosarcoma; ERMS: embryonal rhabdomyosarcoma; RMS: rhabdomyosarcoma.
Berberine; palmatine; rhabdomyosarcoma; three-dimensional culture; tumorsphere
Berberine and palmatine inhibit the growth of human rhabdomyosarcoma cells.
Shinji S1, Nakamura S1, Nihashi Y2, Umezawa K3, Takaya T1,2,3.