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Catalogue Number
BF-P3031
Analysis Method
HPLC,NMR,MS
Specification
98%
Storage
2-8°C
Molecular Weight
256.42
Appearance
White crystal
Botanical Source
Cynomorium songaricum,Ligustrum lucidum,Notopterygium incisum,Sarcandra glabra,Dioscorea polystachya
Structure Type
Others
Category
Standards;Natural Pytochemical;API
SMILES
CCCCCCCCCCCCCCCC(=O)O
Synonyms
n-hexadecanoic acid/1-hexadecanoic acid/hexdecanoic acid/Hexadecanoic acid/Neo-Fat 16/Palmitic acid
IUPAC Name
hexadecanoic acid
Applications
Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants.
Density
0.9±0.1 g/cm3
Solubility
Methanol
Flash Point
154.1±12.5 °C
Boiling Point
340.6±5.0 °C at 760 mmHg
Melting Point
61-62.5 °C(lit.)
InChl
InChl Key
WGK Germany
RID/ADR
HS Code Reference
2915700000
Personal Projective Equipment
Correct Usage
For Reference Standard and R&D, Not for Human Use Directly.
Meta Tag
provides coniferyl ferulate(CAS#:57-10-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
MSDS
23406428
We reviewed the scientific literature on the evidence of the relationship between palm oil and adverse effects on human health. Few studies have investigated the effects of palm oil per se, and the main reason why it has been associated with negative health effects is the relatively high content of saturated fatty acids (SFAs), particularly palmitic acid, which in turn have been associated with increased risk of coronary heart disease and some tumours. However, more recent investigations on the topic seem to have reconsidered the negative role of the dietary SFAs as a risk factor for cardiovascular diseases and show that not only the type of fat, but also that the triglyceride structure plays a role in cholesterolaemia. As regards to a role in cancer, specific studies on dietary palmitic acid or palm oil and the risk of cancer development are scanty, and the evidence is not convincing.
Palm oil and palmitic acid: a review on cardiovascular effects and carcinogenicity.
Fattore E1, Fanelli R.
2013 Aug
31751645
Developmental, and reproductive toxicity; Environmental safety; Genotoxicity; Local respiratory toxicity; Phototoxicity/Photoallergenicity; Repeated dose; Skin sensitization
RIFM fragrance ingredient safety assessment, palmitic acid, CAS Registry Number 57-10-3.
Api AM1, Belmonte F1, Belsito D2, Biserta S1, Botelho D1, Bruze M3, Burton GA Jr4, Buschmann J5, Cancellieri MA1, Dagli ML6, Date M1, Dekant W7, Deodhar C1, Fryer AD8, Gadhia S1, Jones L1, Joshi K1, Lapczynski A1, Lavelle M1, Liebler DC9, Na M1, O'Brien D1, Patel A1, Penning TM10, Ritacco G1, Rodriguez-Ropero F1, Romine J1, Sadekar N1, Salvito D1, Schultz TW11, Siddiqi F1, Sipes IG12, Sullivan G13, Thakkar Y1, Tokura Y14, Tsang S1.
2019 Dec
25697744
BACKGROUND:
The initial burst release is a major obstacle to the development of microsphere-formulated drug products.
PURPOSE:
To investigate the influence of palmitic acid on the characteristics and release profiles of rotigotine-loaded poly(d,l-lactide-co-glycolide) microspheres.
MATERIALS AND METHODS:
Rotigotine-loaded microspheres (RMS) were prepared using the oil-in-water emulsion solvent evaporation technique. The in vitro characteristics of the RMS were evaluated with scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and a particle size analyzer. The in vitro drug release and in vivo pharmacokinetics of the RMS were investigated.
RESULTS AND DISCUSSION:
The SEM results showed that the addition of palmitic acid changed the surface morphology of the microspheres from smooth to dimpled and then to non-smooth as the palmitic acid content increased. DSC revealed the existence of molecularly dispersed forms of palmitic acid in the microspheres. The in vitro and in vivo release profiles indicated that the addition of 5% and 8% palmitic acid significantly decreased the burst release of rotigotine from the microspheres, and the late-stage release was delayed as the palmitic acid content increased across the investigated range (5-15%).
CONCLUSION:
The addition of palmitic acid to the microspheres significantly affects the release profile of rotigotine from RMS.
Burst release; characteristics; palmitic acid; rotigotine-loaded microspheres
Effect of palmitic acid on the characteristics and release profiles of rotigotine-loaded microspheres.
Wang A1, Liang R1, Liu W1, Sha C2, Li Y2, Sun K1.
2016
