Catalogue Number
BF-P3018
Analysis Method
HPLC,NMR,MS
Specification
98%
Storage
-20℃
Molecular Weight
460.73
Appearance
White crystalline powder
Botanical Source
Panax ginseng,Panax notoginseng
Structure Type
Terpenoids
Category
Standards;Natural Pytochemical;API
SMILES
CC1(CCCC(O1)(C)C2CCC3(C2C(CC4C3(CCC5C4(CCC(C5(C)C)O)C)C)O)C)C
Synonyms
PALMITIC ACID METHYLESTER(RG) (SEE METHYL PALMITATE)/(3β,12β,20R)-20,25-Epoxydammarane-3,12-diol/Panaxaidol/DAMMARANE-3BETA,12BETA-DIOL/Dammarane-3,12-diol, 20,25-epoxy-, (3β,12β,20R)-/Panaxadio
IUPAC Name
(3S,5R,8R,9R,10R,12R,13R,14R,17S)-4,4,8,10,14-pentamethyl-17-[(2R)-2,6,6-trimethyloxan-2-yl]-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,12-diol
Density
1.0±0.1 g/cm3
Solubility
Chloroform; Ethyl Acetate
Flash Point
275.1±28.7 °C
Boiling Point
531.3±45.0 °C at 760 mmHg
Melting Point
InChl
InChl Key
WGK Germany
RID/ADR
HS Code Reference
2933590000
Personal Projective Equipment
Correct Usage
For Reference Standard and R&D, Not for Human Use Directly.
Meta Tag
provides coniferyl ferulate(CAS#:19666-76-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
MSDS
30735733
Aim: Alzheimer’s disease (AD), a neurodegenerative disease, is characterized by memory loss and synaptic damage. Up to now, there are limited drugs to cure or delay the state of this illness. Recently, the Fyn tyrosine kinase is implicated in AD pathology triggered by synaptic damage. Thus, Fyn inhibition may prevent or delay the AD progression. Therefore, in this paper, we investigated whether Panaxadiol could decrease synaptic damage in AD and the underlying mechanism.
Main methods: The ability of learning and memory of mice has detected by Morris Water Maze. The pathological changes detected by H&E staining and Nissl staining. The percentage of cell apoptosis and the calcium concentration were detected by Flow Cytometry in vitro. The amount of synaptic protein and related proteins in the Fyn/GluN2B/CaMKIIα signaling pathway were detected by Western Blot.
Key findings: In the present article, Panaxadiol could significantly improve the ability of learning and memory of mice and reduce its synaptic dysfunction. Panaxadiol could down-regulate GluN2B’s phosphorylation level by inhibition Fyn kinase activity, Subsequently, decrease Ca2+-mediated synaptic damage, reducing LDH leakage, inhibiting apoptosis in AD, resulting in facilitating the cells survival. For the underlying molecular mechanism, we used PP2 to block the Fyn/GluN2B/CaMKIIα signaling pathway. The results from WB showed that the expression of related proteins in the Fyn signaling pathway decreased with PP2 treated.
Significance: Our results indicate that Panaxadiol could decrease synaptic damage, which will cause AD via inhibition of the Fyn/GluN2B/CaMKIIα signaling pathway. Thus, the Panaxadiol is a best promising candidate to test as a potential therapy for AD.
Alzheimer's disease; Ca(2+); Fyn; Panaxadiol; Synaptic damage.
Panaxadiol Inhibits Synaptic Dysfunction in Alzheimer's Disease and Targets the Fyn Protein in APP/PS1 Mice and APP-SH-SY5Y Cells
Xicai Liang 1 , Yingjia Yao 1 , Ying Lin 1 , Liang Kong 1 , Honghe Xiao 1 , Yue Shi 1 , Jingxian Yang 2
2019 Mar
32113874
Panaxadiol is a triterpenoid sapogenin monomeric compound found in the roots of Panax ginseng and has a variety of biological activities such as neuroprotective and anti-tumour functions. However, the mechanisms how panaxadiol exerts the anticancer effects remain unknown. The current study aimed to investigate the potential activity of panaxadiol on programmed cell death-ligand 1 (PD-L1) expression and tumour proliferation in human colon cancer cells and to identify the underlying mechanism. Results showed that panaxadiol showed little cytotoxicity as assessed by a cytotoxicity assay and significantly inhibited PD-L1 expression at the protein and mRNA level in a dose-dependent manner. Furthermore, panaxadiol supressed the hypoxia-induced synthesis of hypoxia-inducible factor (HIF)-1α via the phosphoinositide 3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) pathways without affecting HIF-1α degradation. Simultaneously, panaxadiol inhibited STAT3 activation through the JAK1, JAK2, and Src pathways. Moreover, pre-treatment with panaxadiol enhanced the activity of cytotoxic T lymphocytes (CTL) and regained their capacity of tumour cell killing in a T cell and tumour cell co-culture system. Immunoprecipitation showed that panaxadiol inhibited PD-L1 expression by blocking the interaction between HIF-1α and STAT3. The inhibitory effect of panaxadiol on tumour proliferation was further demonstrated by colony formation and EdU labelling assays. The anti-proliferative effect of panaxadiol was also proved by a xenograft assay in vivo. Taken together, the current work highlights the anti-tumour effect of panaxadiol, providing insights into development of cancer therapeutic through PD-L1 inhibition.
Alzheimer's disease; Ca(2+); Fyn; Panaxadiol; Synaptic damage.
Panaxadiol Inhibits Programmed Cell Death-Ligand 1 Expression and Tumour Proliferation via Hypoxia-Inducible Factor (HIF)-1α and STAT3 in Human Colon Cancer Cells
Zhe Wang 1 , Ming Yue Li 1 , Zhi Hong Zhang 1 , Hong Xiang Zuo 1 , Jing Ying Wang 1 , Yue Xing 1 , MyongHak Ri 1 , Hong Lan Jin 1 , Cheng Hua Jin 1 , Guang Hua Xu 1 , Lian Xun Piao 1 , Chang Gao Jiang 2 , Juan Ma 3 , Xuejun Jin 4
2020 Feb 27
31298488
Panaxadiol is a dammarane-type ginsenoside having high ginseng content. The 3-hydroxy group of panaxadiol (PD) was modified by fatty acids and diacids. The modified panax glycol had enhanced anticancer activity. Twelve PD derivatives were evaluated and purified by chemical synthesis, column chromatography, co-synthesis, and identification. The human leukemia cells THP-1, HL-60, and human prostate cancer cell lines PC-3 were evaluated; PD derivatives were tested and evaluated in vitro by MTT assay. The results showed that the antitumor activities of some derivatives on three tumor cell lines were better than those of PD.
antitumor activity; cytotoxicity; ester derivatives; panaxadiol; structural modification.
Esterified Derivatives of Panaxadiol and Their Inhibitory Effect on HL-60, THP-1, and PC-3 Cell Lines
Ziyi Wang 1 2 , Meng Ding 2 , Zhe Lin 2 , Cuiwei He 1 3 , Yuqing Zhao 2 4
2019 Aug
Description :
Panaxadiol is a novel antitumor agent extracted from the Chinese medical herb Panax ginseng.
