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Panaxadiol

$43

  • Brand : BIOFRON

  • Catalogue Number : BF-P3018

  • Specification : 98%

  • CAS number : 19666-76-3

  • Formula : C30H52O3

  • Molecular Weight : 460.73

  • PUBCHEM ID : 73498

  • Volume : 25mg

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Catalogue Number

BF-P3018

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

-20℃

Molecular Weight

460.73

Appearance

White crystalline powder

Botanical Source

Panax ginseng,Panax notoginseng

Structure Type

Terpenoids

Category

Standards;Natural Pytochemical;API

SMILES

CC1(CCCC(O1)(C)C2CCC3(C2C(CC4C3(CCC5C4(CCC(C5(C)C)O)C)C)O)C)C

Synonyms

PALMITIC ACID METHYLESTER(RG) (SEE METHYL PALMITATE)/(3β,12β,20R)-20,25-Epoxydammarane-3,12-diol/Panaxaidol/DAMMARANE-3BETA,12BETA-DIOL/Dammarane-3,12-diol, 20,25-epoxy-, (3β,12β,20R)-/Panaxadio

IUPAC Name

(3S,5R,8R,9R,10R,12R,13R,14R,17S)-4,4,8,10,14-pentamethyl-17-[(2R)-2,6,6-trimethyloxan-2-yl]-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,12-diol

Density

1.0±0.1 g/cm3

Solubility

Chloroform; Ethyl Acetate

Flash Point

275.1±28.7 °C

Boiling Point

531.3±45.0 °C at 760 mmHg

Melting Point

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2933590000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:19666-76-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

30735733

Abstract

Aim: Alzheimer’s disease (AD), a neurodegenerative disease, is characterized by memory loss and synaptic damage. Up to now, there are limited drugs to cure or delay the state of this illness. Recently, the Fyn tyrosine kinase is implicated in AD pathology triggered by synaptic damage. Thus, Fyn inhibition may prevent or delay the AD progression. Therefore, in this paper, we investigated whether Panaxadiol could decrease synaptic damage in AD and the underlying mechanism.
Main methods: The ability of learning and memory of mice has detected by Morris Water Maze. The pathological changes detected by H&E staining and Nissl staining. The percentage of cell apoptosis and the calcium concentration were detected by Flow Cytometry in vitro. The amount of synaptic protein and related proteins in the Fyn/GluN2B/CaMKIIα signaling pathway were detected by Western Blot.
Key findings: In the present article, Panaxadiol could significantly improve the ability of learning and memory of mice and reduce its synaptic dysfunction. Panaxadiol could down-regulate GluN2B’s phosphorylation level by inhibition Fyn kinase activity, Subsequently, decrease Ca2+-mediated synaptic damage, reducing LDH leakage, inhibiting apoptosis in AD, resulting in facilitating the cells survival. For the underlying molecular mechanism, we used PP2 to block the Fyn/GluN2B/CaMKIIα signaling pathway. The results from WB showed that the expression of related proteins in the Fyn signaling pathway decreased with PP2 treated.
Significance: Our results indicate that Panaxadiol could decrease synaptic damage, which will cause AD via inhibition of the Fyn/GluN2B/CaMKIIα signaling pathway. Thus, the Panaxadiol is a best promising candidate to test as a potential therapy for AD.

KEYWORDS

Alzheimer's disease; Ca(2+); Fyn; Panaxadiol; Synaptic damage.

Title

Panaxadiol Inhibits Synaptic Dysfunction in Alzheimer's Disease and Targets the Fyn Protein in APP/PS1 Mice and APP-SH-SY5Y Cells

Author

Xicai Liang 1 , Yingjia Yao 1 , Ying Lin 1 , Liang Kong 1 , Honghe Xiao 1 , Yue Shi 1 , Jingxian Yang 2

Publish date

2019 Mar

PMID

32113874

Abstract

Panaxadiol is a triterpenoid sapogenin monomeric compound found in the roots of Panax ginseng and has a variety of biological activities such as neuroprotective and anti-tumour functions. However, the mechanisms how panaxadiol exerts the anticancer effects remain unknown. The current study aimed to investigate the potential activity of panaxadiol on programmed cell death-ligand 1 (PD-L1) expression and tumour proliferation in human colon cancer cells and to identify the underlying mechanism. Results showed that panaxadiol showed little cytotoxicity as assessed by a cytotoxicity assay and significantly inhibited PD-L1 expression at the protein and mRNA level in a dose-dependent manner. Furthermore, panaxadiol supressed the hypoxia-induced synthesis of hypoxia-inducible factor (HIF)-1α via the phosphoinositide 3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) pathways without affecting HIF-1α degradation. Simultaneously, panaxadiol inhibited STAT3 activation through the JAK1, JAK2, and Src pathways. Moreover, pre-treatment with panaxadiol enhanced the activity of cytotoxic T lymphocytes (CTL) and regained their capacity of tumour cell killing in a T cell and tumour cell co-culture system. Immunoprecipitation showed that panaxadiol inhibited PD-L1 expression by blocking the interaction between HIF-1α and STAT3. The inhibitory effect of panaxadiol on tumour proliferation was further demonstrated by colony formation and EdU labelling assays. The anti-proliferative effect of panaxadiol was also proved by a xenograft assay in vivo. Taken together, the current work highlights the anti-tumour effect of panaxadiol, providing insights into development of cancer therapeutic through PD-L1 inhibition.

KEYWORDS

Alzheimer's disease; Ca(2+); Fyn; Panaxadiol; Synaptic damage.

Title

Panaxadiol Inhibits Programmed Cell Death-Ligand 1 Expression and Tumour Proliferation via Hypoxia-Inducible Factor (HIF)-1α and STAT3 in Human Colon Cancer Cells

Author

Zhe Wang 1 , Ming Yue Li 1 , Zhi Hong Zhang 1 , Hong Xiang Zuo 1 , Jing Ying Wang 1 , Yue Xing 1 , MyongHak Ri 1 , Hong Lan Jin 1 , Cheng Hua Jin 1 , Guang Hua Xu 1 , Lian Xun Piao 1 , Chang Gao Jiang 2 , Juan Ma 3 , Xuejun Jin 4

Publish date

2020 Feb 27

PMID

31298488

Abstract

Panaxadiol is a dammarane-type ginsenoside having high ginseng content. The 3-hydroxy group of panaxadiol (PD) was modified by fatty acids and diacids. The modified panax glycol had enhanced anticancer activity. Twelve PD derivatives were evaluated and purified by chemical synthesis, column chromatography, co-synthesis, and identification. The human leukemia cells THP-1, HL-60, and human prostate cancer cell lines PC-3 were evaluated; PD derivatives were tested and evaluated in vitro by MTT assay. The results showed that the antitumor activities of some derivatives on three tumor cell lines were better than those of PD.

KEYWORDS

antitumor activity; cytotoxicity; ester derivatives; panaxadiol; structural modification.

Title

Esterified Derivatives of Panaxadiol and Their Inhibitory Effect on HL-60, THP-1, and PC-3 Cell Lines

Author

Ziyi Wang 1 2 , Meng Ding 2 , Zhe Lin 2 , Cuiwei He 1 3 , Yuqing Zhao 2 4

Publish date

2019 Aug


Description :

Panaxadiol is a novel antitumor agent extracted from the Chinese medical herb Panax ginseng.