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Panaxynol

$807

  • Brand : BIOFRON

  • Catalogue Number : BD-P0503

  • Specification : 95.0%(HPLC)

  • CAS number : 21852-80-2

  • Formula : C17H24O

  • Molecular Weight : 244.4

  • PUBCHEM ID : 5281149

  • Volume : 0.05ml

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Catalogue Number

BD-P0503

Analysis Method

Specification

95.0%(HPLC)

Storage

-20℃

Molecular Weight

244.4

Appearance

Oil

Botanical Source

This product is isolated and purified from the roots of Saposhnikovia divaricata

Structure Type

Category

SMILES

CCCCCCCC=CCC#CC#CC(C=C)O

Synonyms

Carotatoxin/(-)-Falcarinol/(-)-Carotatoxin/1,9-Heptadecadiene-4,6-diyn-3-ol, (3R,9Z)-/(-)-Panaxynol/(−)-(3R)-falcarinol/(3R,9Z)-1,9-Heptadecadiene-4,6-diyn-3-ol/Falcarinol/Panaxynol/(3R,9Z)-Heptadeca-1,9-diene-4,6-diyn-3-ol/Falcarinol

IUPAC Name

Applications

Density

0.9±0.1 g/cm3

Solubility

Methanol; Ethyl Acetate; Chloroform

Flash Point

163.4±20.9 °C

Boiling Point

370.6±42.0 °C at 760 mmHg

Melting Point

InChl

InChl Key

UGJAEDFOKNAMQD-QXPKXGMISA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:21852-80-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

31343078

Abstract

INTRODUCTION:
(3S)-16,17-Didehydrofalcarinol (1) has been isolated from Tridax procumbens and has proved to have notorious bioactivity against Leishmania mexicana. In this study, hexane fractions obtained from the methanol extract of each plant part (roots, stems, leaves, flowers, and fruits) of T. procumbens collected monthly during a year were analysed in order to determine the quantity of 1 associated with biotic variables.

OBJECTIVE:
The aim of this study was to find the season of the year in which the bioactive metabolite 1 is at the highest concentration and to correlate it with temperature, length of day light, and rainfall.

METHODS:
Hexane fractions were obtained by liquid-liquid extraction and an accurate quantitation of 1 was performed using gas chromatography with a flame ionisation detector (GC-FID) employing pelargonic acid vanillyl amide (2) as internal standard. Partial validation was based on linearity and precision.

RESULTS:
Our results indicated that the total content of 1 has significant variation (P ≤ 0.05) during the different collecting months. The total content of the metabolite reached its highest level in the roots of the plant during June in the rainfall season (0.0358 ± 0.001 mg/g), and its lowest values in February and March during the drought season (0.0015 ± 0.000 and 0.0008 ± 0.000 mg/g, respectively).

CONCLUSION:
Our study provided evidence that the content of 1 in roots is strongly influenced by the variables of the harvesting season, also indicating that the biosynthesis of the active metabolite is enhanced during the warm and rainy months.

© 2019 John Wiley & Sons, Ltd.

KEYWORDS

(3S)-16,17-didehydrofalcarinol; Leishmania mexicana; Tridax procumbens; falcarinol-type polyacetylene; seasonal variability

Title

Quantitative seasonal variation of the falcarinol-type polyacetylene (3S)-16,17-didehydrofalcarinol and its spatial tissue distribution in Tridax procumbens.

Author

Larque-Garcia H1, Torres-Tapia LW1, Vera-Ku M2, Gamboa-Leon R3, Novelo-Castilla S4, Coral-Martinez TI4, Peraza-Sanchez SR1.

Publish date

2020 Mar;

PMID

30506753

Abstract

Acne is a chronic inflammatory disease of the skin that occurs when bacteria abnormally grow in hair follicles. The most common treatment is antibiotics, but they are limited due to antibiotic resistance. The purpose of this study was to identify the active ingredients of the antimicrobial effects of red ginseng (Panax ginseng C.A. Meyer), compare it to existing antibacterial substances, and determine its potential efficacy as a natural drug product. The hydrophobic fraction in red ginseng ethanol extract (RGEF) showed the same or better antimicrobial activity against Propionibacterium acnes than benzoyl peroxide or azelaic acid. In addition, the antimicrobial component derived from red ginseng selectively showed a high antimicrobial effect on P. acnes. Nuclear magnetic resonance spectroscopic analysis showed that the active antimicrobial substance in this fraction was panaxynol and panaxydol. Twenty subjects who had acne symptoms were treated with cream containing 3 mg/g of RGEF for 4 weeks. It was found that oxidized sebum contents and redness of the skin were reduced, and symptoms of the early to middle stage of acne were effectively improved. This study showed that red ginseng extract containing panaxynol and panaxydol can effectively control the symptoms of acne.

© 2018 John Wiley & Sons, Ltd.

KEYWORDS

Panax ginseng C.A. Meyer; anti-acne; antibacterial ingredient; panaxydol; panaxynol; red ginseng

Title

Anti-acne properties of hydrophobic fraction of red ginseng (Panax ginseng C.A. Meyer) and its active components.

Author

Hou JH1,2, Shin H2, Jang KH2, Park CK2, Koo B2, Shin H1, Yuk SH1, Lee KY1.

Publish date

2019 Mar;

PMID

30420908

Abstract

Nuclear factor- (erythroid-derived 2) like 2 (Nrf2) is a transcription factor that regulates the expression of a battery of antioxidant, anti-inflammatory, and cytoprotective enzymes including heme oxygenase-1 (Hmox1, Ho-1) and NADPH:quinone oxidoreductase-1 (Nqo1). The isothiocyanate sulforaphane (SF) is widely understood to be the most effective natural activator of the Nrf2 pathway. Falcarinol (FA) is a lesser studied natural compound abundant in medicinal plants as well as dietary plants from the Apiaceae family such as carrot. We evaluated the protective effects of FA and SF (5 mg/kg twice per day in CB57BL/6 mice) pretreatment for one week against acute intestinal and systemic inflammation. The phytochemical pretreatment effectively reduced the magnitude of intestinal proinflammatory gene expression (IL-6, Tnfα/Tnfαr, Infγ, STAT3, and IL-10/IL-10r) with FA showing more potency than SF. FA was also more effective in upregulating Ho-1 at mRNA and protein levels in both the mouse liver and the intestine. FA but not SF attenuated plasma chemokine eotaxin and white blood cell growth factor GM-CSF, which are involved in the recruitment and stabilization of first-responder immune cells. Phytochemicals generally did not attenuate plasma proinflammatory cytokines. Plasma and intestinal lipid peroxidation was also not significantly changed 4 h after LPS injection; however, FA did reduce basal lipid peroxidation in the mesentery. Both phytochemical pretreatments protected against LPS-induced reduction in intestinal barrier integrity, but FA additionally reduced inflammatory cell infiltration even below negative control.

Title

Falcarinol Is a Potent Inducer of Heme Oxygenase-1 and Was More Effective than Sulforaphane in Attenuating Intestinal Inflammation at Diet-Achievable Doses.

Author

Stefanson AL1, Bakovic M1.

Publish date

2018 Oct 21;