We Offer Worldwide Shipping
Login Wishlist

Paradol

$572

  • Brand : BIOFRON

  • Catalogue Number : BD-P0366

  • Specification : 95.0%(HPLC)

  • CAS number : 27113-22-0

  • Formula : C17H26O3

  • Molecular Weight : 278.39

  • Volume : 25mg

Available on backorder

Quantity
Checkout Bulk Order?

Catalogue Number

BD-P0366

Analysis Method

HPLC,NMR,MS

Specification

95.0%(HPLC)

Storage

-20℃

Molecular Weight

278.39

Appearance

Botanical Source

Structure Type

Other Phenolic Compounds

Category

SMILES

CCCCCCCC(=O)CCC1=CC(=C(C=C1)O)OC

Synonyms

IUPAC Name

Applications

Density

1.0±0.1 g/cm3

Solubility

DMSO : ≥ 140 mg/mL (502.89 mM)
*"≥" means soluble, but saturation unknown.

Flash Point

140.0±18.1 °C

Boiling Point

406.5±30.0 °C at 760 mmHg

Melting Point

InChl

InChI=1S/C17H26O3/c1-3-4-5-6-7-8-15(18)11-9-14-10-12-16(19)17(13-14)20-2/h10,12-13,19H,3-9,11H2,1-2H3

InChl Key

CZNLTCTYLMYLHL-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

2914500000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:27113-22-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

29542131

Abstract

Background: Grains of paradise (GP) is the seed of Aframomum melegueta, which is widely distributed throughout West Africa and has been used as a spice and a folk remedy for a long time. Anti-obesity effect of GP intake was demonstrated in a previous report. Aim of the present study was to isolate some compounds in GP and clarify the anti-obesity mechanism.

Results: Ten vanilloid compounds were isolated. Among them, 1-(4′-hydroxy-3′-methoxyphenyl)-decan-3-ol and 1-(4′-hydroxy-3′-methoxyphenyl)-3-octen-5-one were determined as novel compounds and 6-gingerol, 6-paradol and 6-shogaol were identified as the major constituents in GP extract. Moreover, the extract and 6-gingerol, which is one of the principal components of GP extract, were orally administered to rats to investigate the effect on sympathetic nerve activity (SNA) in brown adipose tissue (BAT). The injection of GP extract and 6-gingerol decreased BAT-SNA, whereas capsaicin, which is a major component of chili pepper, activates the sympathetic nervous system.

Conclusion: This study suggested that GP extract and 6-gingerol were largely unrelated to the anti-obesity effect by the activation of interscapular BAT-SNA and had a different anti-obesity mechanism to capsaicin. © 2018 Society of Chemical Industry.

KEYWORDS

BAT-SNA; anti-obesity effect; grains of paradise; vanilloid.

Title

Identification of vanilloid compounds in grains of paradise and their effects on sympathetic nerve activity

Author

Hiroyuki Hattori 1, Kosei Yamauchi 2, Siaw Onwona-Agyeman 3, Tohru Mitsunaga 4

Publish date

2018 Sep

PMID

28274629

Abstract

Paradols are unsaturated ketones produced by biotransformation of shogaols in gingers. Among them, 6-paradol has been investigated as a new drug candidate due to its anti-inflammatory, apoptotic, and neuroprotective activities. In this study, the inhibitory effects of 6-paradol on the activities of cytochrome P450 (CYP) enzymes were investigated with human liver microsomes and recombinant CYP isozymes. 6-Paradol showed concentration-dependent inhibitory effects on CYP1A2, CYP2B6, CYP2C8, CYP2C9, and CYP2C19 isozymes, with IC50 values ranging from 3.8 to 21.4µM in recombinant CYP isozymes. However, the inhibition was not potentiated following pre-incubation, indicating that 6-paradol is not a mechanism-based inhibitor. These results suggest that pharmacokinetic drug-drug interactions might occur with 6-paradol, which must be considered in the process of new drug development.

KEYWORDS

6-Paradol; CYP inhibition; Drug-drug interaction; Ginger; Unsaturated ketone.

Title

Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism

Author

Hyeong Jun Kim 1, In Sook Kim 1, Shaheed Ur Rehman 2, Sang Keun Ha 3, Katsunori Nakamura 4, Hye Hyun Yoo 5

Publish date

2017 Apr 15;

PMID

28106738

Abstract

The anti-diabetic activity of ginger powder (Zingiber officinale) has been recently promoted, with the recommendation to be included as one of the dietary supplements for diabetic patients. However, previous studies presented different results, which may be caused by degradation and metabolic changes of ginger components, gingerols, shogaols and paradols. Therefore, we prepared 10 ginger active components, namely 6-, 8-, 10-paradols, 6-, 8-, 10-shogaols, 6-, 8-, 10-gingerols and zingerone, and evaluated their anti-hyperglycemic activity. Among the tested compounds, 6-paradol and 6-shogaol showed potent activity in stimulating glucose utilization by 3T3-L1 adipocytes and C2C12 myotubes. The effects were attributed to the increase in 5′ adenosine monophosphate-activated protein kinase (AMPK) phosphorylation in 3T3-L1 adipocytes. 6-Paradol, the major metabolite of 6-shogaol, was utilized in an in vivo assay and significantly reduced blood glucose, cholesterol and body weight in high-fat diet-fed mice.

KEYWORDS

3T3-L1 adipocytes; 6-paradol; C2C12 myotubes; diabetes mellitus; high-fat diet-fed mice; shogaols.

Title

6-Paradol and 6-Shogaol, the Pungent Compounds of Ginger, Promote Glucose Utilization in Adipocytes and Myotubes, and 6-Paradol Reduces Blood Glucose in High-Fat Diet-Fed Mice

Author

Chien-Kei Wei 1, Yi-Hong Tsai 2, Michal Korinek 3, Pei-Hsuan Hung 4, Mohamed El-Shazly 5 6, Yuan-Bin Cheng 7, Yang-Chang Wu 8 9 10 11, Tusty-Jiuan Hsieh 12 13 14 15, Fang-Rong Chang 16 17 18

Publish date

2017 Jan 17;