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Paxiphylline E

$1,280

  • Brand : BIOFRON

  • Catalogue Number : BN-O0572

  • Specification : 98%(HPLC)

  • CAS number : 1092555-03-7

  • Formula : C23H29NO5

  • Molecular Weight : 399.48

  • PUBCHEM ID : 25156646

  • Volume : 5mg

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Catalogue Number

BN-O0572

Analysis Method

HPLC,NMR,MS

Specification

98%(HPLC)

Storage

-20℃

Molecular Weight

399.48

Appearance

Powder

Botanical Source

This product is isolated and purified from the herbs of Daphniphyllum paxianum

Structure Type

Alkaloids

Category

Standards;Natural Pytochemical;API

SMILES

CC1C[N+]2(CC3CCC4=C5C(=C(CC56C3(C2CC1C6=O)C)C(=O)OC)CCO4)[O-]

Synonyms

Methyl (1S,2S,3R,5R,6S,8R,10S)-2,6-dimethyl-21-oxo-14-oxa-8-azahexacyclo[11.6.1.1.0.0.0]henicosa-13(20),17-diene-18-carboxylate 8-oxide/2H-10,11c-Methanopyrano[4',3',2':1,8]azuleno[4,5-a]indolizine-13-carboxylic acid, 1,4,5,5a,6,8,9,10,11,11a,11b,12-dodecahydro-9,11b-dimethyl-14-oxo-, methyl ester, 7-oxide, (5aS,7R,9S,10R,11aR,11bS,11cS)-

IUPAC Name

methyl (1S,2S,3R,5R,6S,10S)-2,6-dimethyl-8-oxido-21-oxo-14-oxa-8-azoniahexacyclo[11.6.1.11,5.02,10.03,8.017,20]henicosa-13(20),17-diene-18-carboxylate

Applications

Density

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

Boiling Point

Melting Point

InChl

InChI=1S/C23H29NO5/c1-12-10-24(27)11-13-4-5-17-19-14(6-7-29-17)16(21(26)28-3)9-23(19)20(25)15(12)8-18(24)22(13,23)2/h12-13,15,18H,4-11H2,1-3H3/t12-,13-,15-,18-,22-,23+,24?/m1/s1

InChl Key

OHPSOIUFKKLGIW-JCRWCHDVSA-N

WGK Germany

RID/ADR

HS Code Reference

2933990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:1092555-03-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

26405601

Abstract

Patients with glioblastoma multiforme (GBM) are immunosuppressed and have a broad range of immunological defects in both innate and adaptive immune responses. GBMs are frequently infected with human cytomegalovirus (HCMV), a virus capable of causing immunosuppression. In 42 HCMV-positive GBM patients in a clinical trial (VIGAS), we investigated T-cell phenotypes in the blood and assessed their relation to survival. Blood was collected before and 3, 12, and 24 weeks after surgery, and the frequency of T-cell subsets was compared with that in 26 age-matched healthy controls. GBM patients had lower levels of CD3 cells than the controls, but had significantly higher levels of CD4+CD28− T cells before and 3 and 12 weeks after surgery and increased levels of CD4+CD57+ and CD4+CD57+CD28+ T cells at all-time points. These T-cell subsets were associated with both immunosenescence and HCMV infection. GBM patients also had higher levels of γδ T cells at all-times after surgery and lower levels of CD4+CD25+ cells before and 3 weeks after surgery than healthy controls. Overall survival was significantly shorter in patients with higher levels of CD4+CD28− T cells (p = 0.025), CD4+CD57+ T (p = 0.025) cells, and CD4+CD28−CD57+CD28− T cells (p < 0.0004) at 3 weeks after surgery. Our findings indicate that signs of immunosenescence in the CD4+ compartment are associated with poor prognosis in patients with HCMV-positive GBMs and may reflect the HCMV activity in their tumors.

KEYWORDS

cytomegalovirus, glioblastoma, immunosenescence, survival, T cells

Title

Poor survival in glioblastoma patients is associated with early signs of immunosenescence in the CD4 T-cell compartment after surgery

Author

Olesja Fornara,1 Jenny Odeberg,1 Nina Wolmer Solberg,1 Charlotte Tammik,1 Petra Skarman,1 Inti Peredo,1,2 Giuseppe Stragliotto,1,3 Afsar Rahbar,1,$* and Cecilia Soderberg-Naucler1,$

Publish date

2015 Sep