3',4',5,6-tetrahydroxy-7-methoxyflavone/FLAVONE,3',4',5,6-TETRAHYDROXY-7-METHOXY/2-(3,4-Dihydroxyphenyl)-5,6-dihydroxy-7-methoxy-4H-chromen-4-one/Pedalitin/2-(3,4-dihydroxyphenyl)-5,6-dihydroxy-7-methoxychromen-4-one/4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-5,6-dihydroxy-7-methoxy-/5,6,3',4'-Tetrahydroxy-7-methoxyflavone/6-Hydroxyluteolin 7-methyl ether
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
659.3±55.0 °C at 760 mmHg
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Personal Projective Equipment
For Reference Standard and R&D, Not for Human Use Directly.
provides coniferyl ferulate(CAS#:22384-63-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
Cryptococcosis is an opportunistic fungal infection responsible for high morbidity and mortality in immunocompromised patients. Combination of antifungal substances is a promising way to increase the percentage of successful treatment. Pedalitin (PED) is a natural substance obtained from Pterogyne nitens. The aim of this study was to verify the efficacy of PED alone and in combination with amphotericin B (AmB) in vitro and in vivo against Cryptococcus spp. In the in vitro assay, minimum inhibitory concentrations (MICs) of 0.125 mg/L for AmB and 3.9 mg/L for PED were found when the substances were tested alone, whilst in the combination treatment the active concentration of both decreased, with MICs of 0.03 mg/L for AmB and 1 mg/L for PED. In the survival assay, fungal burden study and histopathological assays it was possible to study the efficacy of the substances alone and in combination. The efficacy of combination therapy was considered better than monotherapy as evaluated in a Galleria mellonella model and a murine model. Thus, the combination of PED and AmB is an interesting alternative for anticryptococcal fungal treatment. Moreover, a correlation was observed between the invertebrate and murine models for this antifungal treatment combination.
Copyright © 2016 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.
Amphotericin B; Chequerboard; Cryptococcus neoformans; Galleria mellonella; Pedalitin
Synergistic effect of pedalitin and amphotericin B against Cryptococcus neoformans by in vitro and in vivo evaluation.
Sangalli-Leite F1, Scorzoni L1, Alves de Paula E Silva AC1, da Silva JF1, de Oliveira HC1, de Lacorte Singulani J1, Gullo FP1, Moraes da Silva R1, Regasini LO2, Siqueira da Silva DH2, da Silva Bolzani V2, Fusco-Almeida AM1, Soares Mendes-Giannini MJ3.
Pedalium murex L. is a medicinal herb that has been used for the treatment of diseases related to kidney in the traditional system of medicine. The current study aims to study the effect of ethyl acetate extract of P. murex (EAEP) and its fractionated compound pedalitin against urease production and UreC gene expression in Proteus mirabilis. The selected reference strain Proteus mirabilis (MTCC 425) and the isolates culture of Proteus mirabilis were subjected to study the antibacterial efficacy of P. murex. Expression analysis of P. mirabilis urease gene was successfully done by QPCR. The ethyl acetate extract effectively inhibit the reference Proteus mirabilis and bacterial isolates of Proteus mirabilis in the clinical samples studied. EAEP has showed more potent activity (56.7%) against urease enzyme and pedalitin also exhibited potent activity (30.1%). Using qPCR, the expression of UreC gene of P. mirabilis was controlled by EAEP and also its bioactive compound pedalitin. The present study clearly demonstrated the potency of P. murex in controlling the growth of pathogenic P. mirabilis and to control the expression of urease enzyme production as well as to restrict the urease gene expression in P. mirabilis.
© 2020 The Authors.
Pedalitin; Pedalium murex; Proteus mirabilis; UreC; qPCR
Effect of traditionally used herb Pedalium murex L. and its active compound pedalitin on urease expression - For the management of kidney stone.
Ramadevi S1, Kaleeswaran B2, Ilavenil S3, Upgade A4, Tamilvendan D5, Rajakrishnan R6, Alfarhan AH6, Kim YO7, Kim HJ8.