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Pedalitin

$980

  • Brand : BIOFRON

  • Catalogue Number : AV-C10480

  • Specification : 98%

  • CAS number : 22384-63-0

  • Formula : C16H12O7

  • Molecular Weight : 316.3

  • PUBCHEM ID : 31161

  • Volume : 5mg

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Catalogue Number

AV-C10480

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

316.3

Appearance

Yellow powder

Botanical Source

Structure Type

Flavonoids

Category

Standards;Natural Pytochemical;API

SMILES

COC1=C(C(=C2C(=C1)OC(=CC2=O)C3=CC(=C(C=C3)O)O)O)O

Synonyms

3',4',5,6-tetrahydroxy-7-methoxyflavone/FLAVONE,3',4',5,6-TETRAHYDROXY-7-METHOXY/2-(3,4-Dihydroxyphenyl)-5,6-dihydroxy-7-methoxy-4H-chromen-4-one/Pedalitin/2-(3,4-dihydroxyphenyl)-5,6-dihydroxy-7-methoxychromen-4-one/4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-5,6-dihydroxy-7-methoxy-/5,6,3',4'-Tetrahydroxy-7-methoxyflavone/6-Hydroxyluteolin 7-methyl ether

IUPAC Name

2-(3,4-dihydroxyphenyl)-5,6-dihydroxy-7-methoxychromen-4-one

Applications

Density

1.6±0.1 g/cm3

Solubility

Amphotericin B; Chequerboard; Cryptococcus neoformans; Galleria mellonella; Pedalitin

Flash Point

251.0±25.0 °C

Boiling Point

659.3±55.0 °C at 760 mmHg

Melting Point

InChl

InChI=1S/C16H12O7/c1-22-13-6-12-14(16(21)15(13)20)10(19)5-11(23-12)7-2-3-8(17)9(18)4-7/h2-6,17-18,20-21H,1H3

InChl Key

QWUHUBDKQQPMQG-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

2914500000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:22384-63-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

27742203

Abstract

Cryptococcosis is an opportunistic fungal infection responsible for high morbidity and mortality in immunocompromised patients. Combination of antifungal substances is a promising way to increase the percentage of successful treatment. Pedalitin (PED) is a natural substance obtained from Pterogyne nitens. The aim of this study was to verify the efficacy of PED alone and in combination with amphotericin B (AmB) in vitro and in vivo against Cryptococcus spp. In the in vitro assay, minimum inhibitory concentrations (MICs) of 0.125 mg/L for AmB and 3.9 mg/L for PED were found when the substances were tested alone, whilst in the combination treatment the active concentration of both decreased, with MICs of 0.03 mg/L for AmB and 1 mg/L for PED. In the survival assay, fungal burden study and histopathological assays it was possible to study the efficacy of the substances alone and in combination. The efficacy of combination therapy was considered better than monotherapy as evaluated in a Galleria mellonella model and a murine model. Thus, the combination of PED and AmB is an interesting alternative for anticryptococcal fungal treatment. Moreover, a correlation was observed between the invertebrate and murine models for this antifungal treatment combination.

Copyright ? 2016 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.

KEYWORDS

Amphotericin B; Chequerboard; Cryptococcus neoformans; Galleria mellonella; Pedalitin

Title

Synergistic effect of pedalitin and amphotericin B against Cryptococcus neoformans by in vitro and in vivo evaluation.

Author

Sangalli-Leite F1, Scorzoni L1, Alves de Paula E Silva AC1, da Silva JF1, de Oliveira HC1, de Lacorte Singulani J1, Gullo FP1, Moraes da Silva R1, Regasini LO2, Siqueira da Silva DH2, da Silva Bolzani V2, Fusco-Almeida AM1, Soares Mendes-Giannini MJ3.

PMID

32127759

Abstract

Pedalium murex L. is a medicinal herb that has been used for the treatment of diseases related to kidney in the traditional system of medicine. The current study aims to study the effect of ethyl acetate extract of P. murex (EAEP) and its fractionated compound pedalitin against urease production and UreC gene expression in Proteus mirabilis. The selected reference strain Proteus mirabilis (MTCC 425) and the isolates culture of Proteus mirabilis were subjected to study the antibacterial efficacy of P. murex. Expression analysis of P. mirabilis urease gene was successfully done by QPCR. The ethyl acetate extract effectively inhibit the reference Proteus mirabilis and bacterial isolates of Proteus mirabilis in the clinical samples studied. EAEP has showed more potent activity (56.7%) against urease enzyme and pedalitin also exhibited potent activity (30.1%). Using qPCR, the expression of UreC gene of P. mirabilis was controlled by EAEP and also its bioactive compound pedalitin. The present study clearly demonstrated the potency of P. murex in controlling the growth of pathogenic P. mirabilis and to control the expression of urease enzyme production as well as to restrict the urease gene expression in P. mirabilis.

? 2020 The Authors.

KEYWORDS

Pedalitin; Pedalium murex; Proteus mirabilis; UreC; qPCR

Title

Effect of traditionally used herb Pedalium murex L. and its active compound pedalitin on urease expression - For the management of kidney stone.

Author

Ramadevi S1, Kaleeswaran B2, Ilavenil S3, Upgade A4, Tamilvendan D5, Rajakrishnan R6, Alfarhan AH6, Kim YO7, Kim HJ8.

Publish date

2020 Mar