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Perilla ketone

$960

  • Brand : BIOFRON

  • Catalogue Number : BN-O1798

  • Specification : 98%(HPLC)

  • CAS number : 553-84-4

  • Formula : C10H14O2

  • Molecular Weight : 166.22

  • PUBCHEM ID : 68381

  • Volume : 25mg

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Catalogue Number

BN-O1798

Analysis Method

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

166.22

Appearance

Botanical Source

Structure Type

Category

SMILES

CC(C)CCC(=O)C1=COC=C1

Synonyms

Perilla ketone/1-furan-3-yl-4-methyl-pentan-1-one/Purple mint plant extract

IUPAC Name

1-(furan-3-yl)-4-methylpentan-1-one

Density

0.976g/cm3

Solubility

Flash Point

96.8ºC

Boiling Point

224.4ºC at 760mmHg

Melting Point

InChl

InChl Key

LVHLZMUFIYAEQB-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:553-84-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

7687599

Abstract

Perilla ketone (PK) is a potent lung toxin that causes increased microvascular permeability pulmonary edema in grazing animals. Because the mechanism of action of PK is not know, we investigated whether PK directly affects endothelial cells. Bovine aortic endothelial cells were grown to confluence on Cytodex-3 microcarrier beads and placed in a chromatographic cell column. Monolayer permeability was evaluated from the elution profiles of three optical tracers: blue dextran (2 x 10(6) mol wt), sodium fluorescein (NaF, 342 mol wt), and cyanocobalamin (B12, 1,355 mol wt). Perfusion with 1.2 mM PK increased permeability within 15 min to NaF and B12 by 51 +/- 6 and 54 +/- 11%, respectively. Permeability returned to baseline after PK removal. These in vitro results suggest that PK produces a rapid and reversible increase in endothelial permeability directly. Staining of fixed cells with rhodamine-phalloidin revealed a major disruption of actin microfilaments after PK treatment. Because previous reports suggested that PK may be activated via cytochrome P-450, we attempted to block this using the cytochrome P-450 inhibitor ketoconazole. Ketoconazole alone did not significantly affect permeability, and the combination of PK and ketoconazole resulted in permeability increases similar to those measured for PK alone. This suggests that PK may not require cytochrome P-450 to increase vascular permeability.

Title

Perilla ketone increases endothelial cell monolayer permeability in vitro.

Author

Waters CM1, Alexander JS, Harris TR, Haselton FR.

Publish date

1993 May

PMID

3688648

Abstract

A model of increased microvascular permeability pulmonary edema was developed in chronically instrumented unanesthetized sheep using perilla ketone (PK). PK did not cause changes in pulmonary hemodynamics but did cause marked increases in the flow of protein-rich lung lymph. The changes in lung lymph flow were accompanied by radiographic evidence of both interstitial and alveolar pulmonary edema as well as hypoxemia. PK did not cause acute changes in lung mechanics. Dynamic compliance of the lungs and FRC decreased later, concomitant with the changes in lung lymph flow, radiographic evidence for pulmonary edema, and hypoxemia. Resistance to air flow across the lungs and specific conductance did not change significantly after PK infusion. The severity of the radiographic evidence for pulmonary edema observed after PK correlated with the severity of the concomitant hypoxemia and changes in dynamic compliance of the lungs. PK did not cause increases in the concentrations of cyclooxygenase products of arachidonic acid in lung lymph or plasma or changes in blood leukocyte counts. We conclude that PK causes increased lung microvascular permeability pulmonary edema without acute changes in pulmonary hemodynamics. This model permits study of the pathophysiologic aspects of increased lung microvascular permeability without the concomitant functional alterations that complicate most other experimental models of diffuse lung injury.

Title

Perilla ketone: a model of increased pulmonary microvascular permeability pulmonary edema in sheep.

Author

Coggeshall JW1, Lefferts PL, Butterfield MJ, Bernard GR, Carroll FE, Pou NA, Snapper JR.

Publish date

1987 Dec

PMID

877573

Abstract

Perilla ketone, from the essential oil of Perilla frutescens, is a potent pulmonary edemagenic agent for laboratory animals and livestock. This finding would account for reported effects of the plant on grazing cattle. The use of perilla in oriental foods and medicinal preparations suggests possible hazards to human health as well.

Title

Perilla ketone: a potent lung toxin from the mint plant, Perilla frutescens Britton.

Author

Wilson BJ, Garst JE, Linnabary RD, Channell RB.

Publish date

1977 Aug 5


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