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Phebalosin

$896

  • Brand : BIOFRON

  • Catalogue Number : BN-O2112

  • Specification : 98%(HPLC)

  • CAS number : 6545-99-9

  • Formula : C15H14O4

  • Molecular Weight : 258.3

  • PUBCHEM ID : 188300

  • Volume : 5mg

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Catalogue Number

BN-O2112

Analysis Method

HPLC,NMR,MS

Specification

98%(HPLC)

Storage

-20℃

Molecular Weight

258.3

Appearance

Cryst.

Botanical Source

This product is isolated and purified from the herbs of Murraya exotica L.

Structure Type

Coumarins

Category

Standards;Natural Pytochemical;API

SMILES

CC(=C)C1C(O1)C2=C(C=CC3=C2OC(=O)C=C3)OC

Synonyms

8-[(2R,3R)-3-Isopropenyl-2-oxiranyl]-7-methoxy-2H-chromen-2-one/2H-1-Benzopyran-2-one, 7-methoxy-8-[(2R,3R)-3-(1-methylethenyl)oxiranyl]-

IUPAC Name

7-methoxy-8-[(2R,3R)-3-prop-1-en-2-yloxiran-2-yl]chromen-2-one

Applications

Density

1.3±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

187.7±28.8 °C

Boiling Point

418.8±45.0 °C at 760 mmHg

Melting Point

InChl

InChI=1S/C18H10O2/c19-17-13-7-3-4-8-14(13)18(20)16-12-6-2-1-5-11(12)9-10-15(16)17/h1-10H

InChl Key

YTDNHMHONBWCBV-UKRRQHHQSA-N

WGK Germany

RID/ADR

HS Code Reference

2932200000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:6545-99-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

29385309

Abstract

The objective of this study was to develop a consecutive preparation method for the isolation and purification of hainanmurpanin, meranzin, and phebalosin from leaves of Murraya exotica L. The process involved supercritical fluid extraction with CO2 , solvent extraction, and two-step high-speed countercurrent chromatography. Pressure, temperature, and the volume of entrainer were optimized as 27 MPa, 52°C, and 60 mL by response surface methodology in supercritical fluid extraction with CO2 , and the yield of the crude extracts was 7.91 g from 100 g of leaves. Subsequently, 80% methanol/water was used to extract and condense the three compounds from the crude extracts, and 4.23 g of methanol/water extracts was obtained. Then, a two-step high-speed countercurrent chromatography procedure was developed for the isolation of the three target compounds from methanol/water extracts, including conventional high-speed countercurrent chromatography for further enrichment and consecutive high-speed countercurrent chromatography for purification. The yield of concentrates from high-speed countercurrent chromatography was 2.50 g from 4.23 g of methanol/water extracts. Finally, the consecutive high-speed countercurrent chromatography produced 103.2 mg of hainanmurpanin, 244.7 mg of meranzin, and 255.4 mg of phebalosin with purities up to 97.66, 99.36, and 98.64%, respectively, from 900 mg of high-speed countercurrent chromatography concentrates in one run of three consecutive sample loadings without exchanging a solvent system.

KEYWORDS

hainanmurpanin; high-speed countercurrent chromatography; meranzin; phebalosin; supercritical fluid extraction.

Title

Preparative Isolation and Purification of Hainanmurpanin, Meranzin, and Phebalosin From Leaves of Murraya Exotica L. Using Supercritical Fluid Extraction Combined With Consecutive High-Speed Countercurrent Chromatography

Author

Rongwei Yan 1, Jie Shen 1, Xiaojing Liu 2, Yong Zou 1 3, Xinjun Xu 1 3

Publish date

2018 May;

PMID

24218965

Abstract

Objective: To study the chemical constituents from ethyl acetate extract of Micromelum falcatum.

Methods: The constituents were separated and purified by silica gel, Sephadex LH-20 and HPLC. Their structures were elucidated by spectral analysis (NMR, MS).

Results: Ten compounds were isolated and identified as micropubescin (1), phebalosin (2), scopoletin (3), citrubuntin (4), thamnosmonin (5), hopeyhopin (6), arnottinin (7), casegravol (8), 2-methoxy-5-hydroxy cinnamate (9), threo-syringoylglycerol (10).

Conclusion: Compounds 1 – 10 are obtained from this plant for the first time.

Title

[Study on the Chemical Constituents From Ethyl Acetate Extract of Micromelum Falcatum]

Author

Sheng Huang 1, Xiong-Ming Luo, Jian-Hua Wang

Publish date

2013 May

PMID

3754570

Title

Phebalosin From the Bark of Micromelum Minutum

Author

V Tantishaiyakul, S Pummangura, C Chaichantipyuth, W W Ma, J L McLaughlin

Publish date

Jan-Feb 1986