We Offer Worldwide Shipping
Login Wishlist

Phenformin hydrochloride

$72

  • Brand : BIOFRON

  • Catalogue Number : BN-O1215

  • Specification : 98%(HPLC)

  • CAS number : 834-28-6

  • Formula : C10H16ClN5

  • Molecular Weight : 241.72

  • PUBCHEM ID : 13266

  • Volume : 5mg

Available on backorder

Quantity
Checkout Bulk Order?

Catalogue Number

BN-O1215

Analysis Method

Specification

98%(HPLC)

Storage

-20℃

Molecular Weight

241.72

Appearance

Powder

Botanical Source

Structure Type

Category

SMILES

C1=CC=C(C=C1)CCN=C(N)N=C(N)N.Cl

Synonyms

Phenformin hydrochloride/Phenformini Hydrochloride/Insora/meltrol/phenforminhclno.9113/Imidodicarbonimidic diamide, N-(2-phenylethyl)-, hydrochloride (1:1)/Glucopostin/Phenformine HCL/dbi-td/β-PEBG HCl/DBI monohydrochloride/usafvi-6/Phenformin HCl/PhenforMin HCl API/Insoral/N-(2-Phenylethyl)imidodicarbonimidic diamide hydrochloride (1:1)/N-Phenethylbiguanide hydrochloride/1-(2-Phenylethyl)biguanide hydrochloride/N'-b-Phenethylformamidinyliminourea Hydrochloride/Phenformin (hydrochloride)/1,1-Benzylmethylbiguanide hydrochloride

IUPAC Name

Density

1.24 g/cm3

Solubility

Flash Point

204ºC

Boiling Point

413.7ºC at 760 mmHg

Melting Point

175-178ºC

InChl

InChl Key

YSUCWSWKRIOILX-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:834-28-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

29426857

Abstract

Methods for quantifying DNA damage, as well as repair of that damage, in a high-throughput format are lacking. Single cell gel electrophoresis (SCGE; comet assay) is a widely-used method due to its technical simplicity and sensitivity, but the standard comet assay has limitations in reproducibility and throughput. We have advanced the SCGE assay by creating a 96-well hardware platform coupled with dedicated data processing software (CometChip Platform). Based on the original cometchip approach, the CometChip Platform increases capacity ~200 times over the traditional slide-based SCGE protocol, with excellent reproducibility. We tested this platform in several applications, demonstrating a broad range of potential uses including the routine identification of DNA damaging agents, using a 74-compound library provided by the National Toxicology Program. Additionally, we demonstrated how this tool can be used to evaluate human populations by analysis of peripheral blood mononuclear cells to characterize susceptibility to genotoxic exposures, with implications for epidemiological studies. In summary, we demonstrated a high level of reproducibility and quantitative capacity for the CometChip Platform, making it suitable for high-throughput screening to identify and characterize genotoxic agents in large compound libraries, as well as for human epidemiological studies of genetic diversity relating to DNA damage and repair.

Title

Next generation high throughput DNA damage detection platform for genotoxic compound screening

Author

Peter Sykora,1 Kristine L. Witt,2 Pooja Revanna,1 Stephanie L. Smith-Roe,2 Jonathan Dismukes,1 Donald G. Lloyd,3 Bevin P. Engelward,4 and Robert W. Sobolcorresponding author1

Publish date

2018;

PMID

8741772

Abstract

This paper presents two types of information from the Carcinogenic Potency Database (CPDB): (a) the sixth chronological plot of analyses of long-term carcinogenesis bioassays, and (b) an index to chemicals in all six plots, including a summary compendium of positivity and potency for each chemical (Appendix 14). The five earlier plots of the CPDB have appeared in this journal, beginning in 1984 (1-5). Including the plot in this paper, the CPDB reports results of 5002 experiments on 1230 chemicals. This paper includes bioassay results published in the general literature between January 1989 and December 1990, and in Technical Reports of the National Toxicology Program between January 1990 and June 1993. Analyses are included on 17 chemicals tested in nonhuman primates by the Laboratory of Chemical Pharmacology, National Cancer Institute. This plot presents results of 531 long-term, chronic experiments of 182 test compounds and includes the same information about each experiment in the same plot format as the earlier papers: the species and strain of test animal, the route and duration of compound administration, dose level and other aspects of experimental protocol, histopathology and tumor incidence, TD50 (carcinogenic potency) and its statistical significance, dose response, author’s opinion about carcinogenicity, and literature citation. We refer the reader to the 1984 publications (1,6,7) for a detailed guide to the plot of the database, a complete description of the numerical index of carcinogenic potency, and a discussion of the sources of data, the rationale for the inclusion of particular experiments and particular target sites, and the conventions adopted in summarizing the literature. The six plots of the CPDB are to be used together since results of individual experiments that were published earlier are not repeated. Appendix 14 is designed to facilitate access to results on all chemicals. References to the published papers that are the source of experimental data are reported in each of the published plots. For readers using the CPDB extensively, a combined plot is available of all results from the six separate plot papers, ordered alphabetically by chemical; the combined plot in printed form or on computer tape or diskette is available from the first author. A SAS database is also available.

Title

Sixth plot of the carcinogenic potency database: results of animal bioassays published in the General Literature 1989 to 1990 and by the National Toxicology Program 1990 to 1993.

Author

L S Gold, N B Manley, T H Slone, G B Garfinkel, B N Ames, L Rohrbach, B R Stern, and K Chow

Publish date

1995 Nov

PMID

8354183

Abstract

This paper is the fifth plot of the Carcinogenic Potency Database (CPDB) that first appeared in this journal in 1984 (1-5). We report here results of carcinogenesis bioassays published in the general literature between January 1987 and December 1988, and in technical reports of the National Toxicology Program between July 1987 and December 1989. This supplement includes results of 412 long-term, chronic experiments of 147 test compounds and reports the same information about each experiment in the same plot format as the earlier papers: the species and strain of test animal, the route and duration of compound administration, dose level and other aspects of experimental protocol, histopathology and tumor incidence, TD50 (carcinogenic potency) and its statistical significance, dose response, author’s opinion about carcinogenicity, and literature citation. We refer the reader to the 1984 publications (1,5,6) for a guide to the plot of the database, a complete description of the numerical index of carcinogenic potency, and a discussion of the sources of data, the rationale for the inclusion of particular experiments and particular target sites, and the conventions adopted in summarizing the literature. The five plots of the database are to be used together, as results of individual experiments that were published earlier are not repeated. In all, the five plots include results of 4487 experiments on 1136 chemicals. Several analyses based on the CPDB that were published earlier are described briefly, and updated results based on all five plots are given for the following earlier analyses: the most potent TD50 value by species, reproducibility of bioassay results, positivity rates, and prediction between species.(ABSTRACT TRUNCATED AT 250 WORDS)

Title

The fifth plot of the Carcinogenic Potency Database: results of animal bioassays published in the general literature through 1988 and by the National Toxicology Program through 1989.

Author

L S Gold, N B Manley, T H Slone, G B Garfinkel, L Rohrbach, and B N Ames

Publish date

1993 Apr


Description :

Empty ...