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Phenol

$78

  • Brand : BIOFRON

  • Catalogue Number : AV-H13052

  • Specification : 98%

  • CAS number : 95041-90-0

  • Formula : C18H22O5

  • Molecular Weight : 318.36

  • PUBCHEM ID : 356759

  • Volume : 20mg

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Catalogue Number

AV-H13052

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

318.36

Appearance

White crystalline powder

Botanical Source

Dendrobium/Eria carinata

Structure Type

Phenols

Category

Standards;Natural Pytochemical;API

SMILES

COC1=C(C=C(C=C1)CCC2=CC(=C(C(=C2)OC)OC)OC)O

Synonyms

Phenol, 2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethyl]-/Dihydrocombretatastin A-4/Erianin/2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)-ethyl]-phenol/5-(3,4,5-trimethoxyphenethyl)-2-methoxyphenol/2-Methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethyl]phenol/(E)-2-methoxy-5-(3,4,5-trimethoxyphenylethyl)phenol/3-hydroxy-3',4',4,5'-tetramethoxybibenzyl/2-Methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethyl]benzolol

IUPAC Name

2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethyl]phenol

Applications

Erianin, often used as an antipyretic and analgesic agent, could inhibit IDO-induced tumor angiogenesis.

Density

1.1±0.1 g/cm3

Solubility

Methanol; Chloroform

Flash Point

219.4±27.3 °C

Boiling Point

439.1±40.0 °C at 760 mmHg

Melting Point

InChl

InChI=1S/C18H22O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h7-11,19H,5-6H2,1-4H3

InChl Key

UXDFUVFNIAJEGM-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:95041-90-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

19402345

Abstract

The purpose of the present study was to examine the pharmacokinetic characteristics of erianin (2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)-ethyl]-phenol, CAS 95041-90-0), a nature product extracted from Dendrobium chrysotoxum, having notable antitumour activity, after intravenous injection of erianin fat emulsion to beagle dogs. An HPLC-MS method was developed to analyze the erianin levels in dog plasma and validated in a pharmacokinetic study. Plasma profiles were obtained after intravenous injection of erianin fat emulsion at the doses 7.5, 15 and 30 mg/kg. The elimination half-life (t(1/2)) values for erianin were estimated to be 1.41+/- 0.31, 1.66 +/- 0.19, 1.60 0.28 h, while the mean area under concentration-time curve (AUC(0-infinity)) values were 1021.3 +/- 373.7, 2305.1 +/- 597.0 and 3952.1 +/- 378.2 ng x h/ml, respectively. In conclusion, the present observations indicated that erianin plasma concentrations were clearly dose-proportional for the dose range studied. There was no gender difference in pharmacokinetics for erianin in male and female dogs.

Title

Liquid chromatographic-mass spectrometry analysis and pharmacokinetic studies of erianin for intravenous injection in dogs.

Author

Zhou H1, Yang B, Hong M, Ma R, Sheng L.

Publish date

2009

PMID

30249042

Abstract

With continuous emergence and widespread of multidrug-resistant Staphylococcus aureus infections, common antibiotics have become ineffective in treating these infections in the clinical setting. Anti-virulence strategies could be novel, effective therapeutic strategies against drug-resistant bacterial infections. Sortase A (srtA), a transpeptidase in gram-positive bacteria, can anchor surface proteins that play a vital role in pathogenesis of these bacteria. SrtA is known as a potential antivirulent drug target to treat bacterial infections. In this study, we found that erianin, a natural bibenzyl compound, could inhibit the activity of srtA in vitro (half maximal inhibitory concentration?IC50 = 20.91 ± 2.31 μg/mL, 65.7 ± 7.2 μM) at subminimum inhibitory concentrations (minimum inhibitory concentrations?MIC = 512 μg/mL against S. aureus). The molecular mechanism underlying the inhibition of srtA by erianin was identified using molecular dynamics simulation: erianin binds to srtA residues Ile182, Val193, Trp194, Arg197, and Ile199, forming a stable bond via hydrophobic interactions. In addition, the activities of S. aureus binding to fibronectin and biofilm formation were inhibited by erianin, when co-culture with S. aureus. In vivo, erianin could improve the survival in mice that infected with S. aureus by tail vein injection. Experimental results showed that erianin is a potential novel therapeutic compound against S. aureus infections via affecting srtA.

KEYWORDS

sortase A, Staphylococcus aureus, erianin, inhibitor, molecular mechanism

Title

Erianin against Staphylococcus aureus Infection via Inhibiting Sortase A

Author

Ping Ouyang,† Xuewen He,† Zhong-Wei Yuan,† Zhong-Qiong Yin, Hualin Fu, Juchun Lin, Changliang He, Xiaoxia Liang, Cheng Lv, Gang Shu, Zhi-Xiang Yuan, Xu Song, Lixia Li, and Lizi Yin*

Publish date

2018 Oct;

PMID

29843091

Abstract

In this study, high-efficient phenol-degrading bacterium Bacillus sp. SAS19 which was isolated from activated sludge by resuscitation-promoting factor (Rpf) addition, were immobilized on porous carbonaceous gels (CGs) for phenol degradation. The phenol-degrading capabilities of free and immobilized Bacillus sp. SAS19 were evaluated under various initial phenol concentrations. The obtained results showed that phenol could be removed effectively by both free and immobilized Bacillus sp. SAS19. Furthermore, for degradation of phenol at high concentrations, long-term utilization and recycling were more readily achieved for immobilized bacteria as compared to free bacteria. Immobilized bacteria exhibited significant increase in phenol-degrading capabilities in the third cycle of recycling and reuse, which demonstrated 87.2% and 100% of phenol (1600?mg/L) degradation efficiency at 12 and 24?h, respectively. The present study revealed that immobilized Bacillus sp. SAS19 can be potentially used for enhanced treatment of synthetic phenol-laden wastewater.

Copyright ? 2018 Elsevier Ltd. All rights reserved.

KEYWORDS

Bacillus sp. SAS19; Carbonaceous gels; Immobilized bacteria; Phenol biodegradation; Resuscitation-promoting factor

Title

Sustainable biodegradation of phenol by immobilized Bacillus sp. SAS19 with porous carbonaceous gels as carriers.

Author

Ke Q1, Zhang Y1, Wu X1, Su X2, Wang Y1, Lin H1, Mei R3, Zhang Y3, Hashmi MZ4, Chen C5, Chen J6.

Publish date

2018 Sep 15