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provides coniferyl ferulate(CAS#:108-95-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
Before Joseph Lister’s landmark Lancet publications on the use of carbolic acid wound dressings in 1867, surgeons Jules Lemaire in France and Enrico Bottini in Italy had already used carbolic acid on hundreds of patients to control suppurative wounds. After Friedlieb Runge isolated it from coal tar in 1834, a number of scientists recognized the efficacy of carbolic acid in preventing decay and neutralizing the stench of dead animals and human cadavers. Frederick Calvert, Alexander McDougall, and Angus Smith in Manchester promoted a powdered form of carbolic acid as a deodorizing agent to treat municipal sewage across the United Kingdom, most notably during London’s famous “Great Stink” of 1858. Edmond Corne in France introduced his formulation, which Alfred-Armand-Louis-Marie Velpeau, Ferdinand LeBeuf, and Lemaire adapted for clinical use in 1859. Lemaire wrote extensively on carbolic acid and its surgical application in three publications from 1860 to 1862. In 1866, Bottini published his experience of 600 cases where it was used. In 1865, Lister began to use carbolic acid in open fractures after Thomas Anderson, his colleague in agricultural chemistry at the University of Glasgow, told him about its use in Carlisle sewage works. This article traces the rich history of carbolic acid from an unknown compound in coal to the cornerstone of Listerism in late-19th-century operating rooms.
Carbolic Acid before Joseph Lister: Rail Ties, Sewage, Manure, and the Great Stink.
Ehrhardt JD Jr, Nakayama DK, O'Leary JP.
2020 Mar 1
Cancer is a major public health problem in many areas of the world. Many anticancer drugs in current clinical use have been isolated from plant species or are based on such substances. Thymol (5-methyl-2-isopropylphenol) is an oxygenated aromatic compound from monoterpene group. It is the main constituent of thyme essential oil and shows antioxidant, antiseptic and antiproliferative properties. The aim of this study is to determine the antiproliferative activity and apoptotic effect of thymol on prostate cancer (PC-3, DU145), breast cancer (MDA-MB-231), and lung cancer (KLN205) cell lines.
The cancer cells were treated with different concentrations of thymol (100, 200, 400, 600, 800 ?M) at 24 h, 48 h and 72 h. The cell viability was investigated by MTT assay and analysis of apoptosis was determined with annexin V assay.
The study showed the dose and time-dependent cytotoxic effect of thymol in PC-3, DU145, MDA-MB-231, and KLN205 cancer cell lines. Thymol significantly induced apoptosis in all groups in a dose-dependent manner. Statistical analysis showed a significant difference between thymol?treated cell lines compared to the control (p < 0.001). CONCLUSION: The data in the present study demonstrated that thymol has apoptotic and antiproliferative properties in lung, breast and prostate cancer cell lines. Thymol could serve as a potential therapeutic agent in the future (Fig. 5, Ref. 26).
apoptosis; cancer antiproliferative.; thymol
Apoptotic effects of thymol, a novel monoterpene phenol, on different types of cancer.
Elbe H, Yigitturk G, Cavusoglu T, Uyanikgil Y, Ozturk F.
The aim of this study was to investigate the characteristic of a newly isolated strain Comamonas sp. ZF-3 involved in typical organics degradation in coking wastewater (CWW). The results showed that the isolated strain had efficient biodegradability of phenolic compounds and heterocyclic compounds in CWW, meanwhile, phenol and indole could be respectively used as sole carbon source for its growth, which demonstrated the bioaugmentation potential of the isolated strain in CWW treatment. During phenol and indole degradation processes, part of metabolites (e.g., 2,3-hexanedione, 2-ethyl-1-hexanol, nonanal, 2-propyl-1-heptanol, butanoic acid, butyl ester and butanoic acid, anhydride) remained in effluents, with NH4+-N concentration having no obvious reduction, which implied the biological treatment of CWW should be accomplished by complex microbial communities in many steps.
Copyright ? 2020 Elsevier Ltd. All rights reserved.
Coking wastewater; Comamonas; Indole; Organics; Phenol
Characterization of a newly isolated strain Comamonas sp. ZF-3 involved in typical organics degradation in coking wastewater.
Yuan K, Li S, Zhong F.