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Phenylbutazone

$96

  • Brand : BIOFRON

  • Catalogue Number : BN-O1320

  • Specification : 98%(HPLC)

  • CAS number : 50-33-9

  • Formula : C19H20N2O2

  • Molecular Weight : 308.37

  • PUBCHEM ID : 4781

  • Volume : 20mg

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Catalogue Number

BN-O1320

Analysis Method

Specification

98%(HPLC)

Storage

-20℃

Molecular Weight

308.37

Appearance

Powder

Botanical Source

Structure Type

Category

SMILES

CCCCC1C(=O)N(N(C1=O)C2=CC=CC=C2)C3=CC=CC=C3

Synonyms

4-Bromo-N-methylaniline/Kadol/A 7514/Uzone/Azolid/Benzenamine, 4-bromo-N-methyl-/4-Butyl-1,2-diphenylpyrazolidine-3,5-dione/Phenylbutazone/PBZ/Azdid/4-Bromo-N-methylbenzenamine/Butoz/pyrazinobutazone/Bute/4-butyl-1,2-diphenyl-3,5-pyrazolidinedione/1,2-diphenyl-4-butyl-3,5-dioxopyrazolidine/Reudo/Buzon

IUPAC Name

Density

1.5±0.1 g/cm3

Solubility

Flash Point

99.2±22.6 °C

Boiling Point

240.4±23.0 °C at 760 mmHg

Melting Point

104-107 °C

InChl

InChl Key

VYMDGNCVAMGZFE-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:50-33-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

847666

Title

[Phenylbutazone].

Author

Rugstad HE.

Publish date

977 Jan 10

PMID

4644645

Title

Phenylbutazone.

Author

Leeson LJ.

Publish date

1972

PMID

30499176

Abstract

Phenylbutazone (PBZ) is a potent mon-steroidal anti-inflammatory drug used commonly in performance horses. The objectives of the current study were to describe blood and urine concentrations and the pharmacokinetics of PBZ and its metabolites following intravenous (IV) and oral administration and to describe the duration of pharmacodynamic effect. To that end, 17 horses received an IV administration and 18 horses an oral administration of 2 g of PBZ. Blood and urine samples were collected prior to and for up to 96 hours post drug administration. Whole blood samples were collected at various time points and challenged with lipopolysaccharide or calcium ionophore to induce ex vivo synthesis of eicosanoids. Concentrations of PBZ and eicosanoids were measured using liquid chromatography-tandem mass spectrometry (LC-MS/MS) and non-compartmental pharmacokinetic analysis performed on concentration data from IV and oral administration. Serum concentrations of PBZ and its metabolites were below the limit of quantitation at 96 hours post administration. The volume of distribution at steady state, systemic clearance, and terminal half-life was 0.194 ± 0.019 L/kg, 23.9 ± 4.48 mL/h/kg, and 10.9 ± 5.32 hours, respectively. The terminal half-life following oral administration was 13.4 ± 3.01 (paste) and 15.1 ± 3.96 hours (tablets). Stimulation of PBZ treated whole blood with lipopolysaccharide and calcium ionophore resulted in an inhibition of TXB2 , PGE2 , LTB4 and 15-HETE production for a prolonged period of time post drug administration. The results of this study suggest that PBZ has a prolonged anti-inflammatory following IV or oral administration of 2 g to horses.

© 2018 John Wiley & Sons, Ltd.

KEYWORDS

eicosanoids; horse; inflammation; pharmacokinetics; phenylbutazone

Title

Phenylbutazone blood and urine concentrations, pharmacokinetics, and effects on biomarkers of inflammation in horses following intravenous and oral administration of clinical doses.

Author

Knych HK1,2, Arthur RM3, McKemie DS1, Seminoff K1, Hamamoto-Hardman B1, Kass PH4.

Publish date

2019 Jun


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