Catalogue Number
BN-O1320
Analysis Method
Specification
98%(HPLC)
Storage
-20℃
Molecular Weight
308.37
Appearance
Powder
Botanical Source
Structure Type
Category
SMILES
CCCCC1C(=O)N(N(C1=O)C2=CC=CC=C2)C3=CC=CC=C3
Synonyms
4-Bromo-N-methylaniline/Kadol/A 7514/Uzone/Azolid/Benzenamine, 4-bromo-N-methyl-/4-Butyl-1,2-diphenylpyrazolidine-3,5-dione/Phenylbutazone/PBZ/Azdid/4-Bromo-N-methylbenzenamine/Butoz/pyrazinobutazone/Bute/4-butyl-1,2-diphenyl-3,5-pyrazolidinedione/1,2-diphenyl-4-butyl-3,5-dioxopyrazolidine/Reudo/Buzon
IUPAC Name
Density
1.5±0.1 g/cm3
Solubility
Flash Point
99.2±22.6 °C
Boiling Point
240.4±23.0 °C at 760 mmHg
Melting Point
104-107 °C
InChl
InChl Key
VYMDGNCVAMGZFE-UHFFFAOYSA-N
WGK Germany
RID/ADR
HS Code Reference
Personal Projective Equipment
Correct Usage
For Reference Standard and R&D, Not for Human Use Directly.
Meta Tag
provides coniferyl ferulate(CAS#:50-33-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
No Technical Documents Available For This Product.
847666
[Phenylbutazone].
Rugstad HE.
977 Jan 10
4644645
Phenylbutazone.
Leeson LJ.
1972
30499176
Phenylbutazone (PBZ) is a potent mon-steroidal anti-inflammatory drug used commonly in performance horses. The objectives of the current study were to describe blood and urine concentrations and the pharmacokinetics of PBZ and its metabolites following intravenous (IV) and oral administration and to describe the duration of pharmacodynamic effect. To that end, 17 horses received an IV administration and 18 horses an oral administration of 2 g of PBZ. Blood and urine samples were collected prior to and for up to 96 hours post drug administration. Whole blood samples were collected at various time points and challenged with lipopolysaccharide or calcium ionophore to induce ex vivo synthesis of eicosanoids. Concentrations of PBZ and eicosanoids were measured using liquid chromatography-tandem mass spectrometry (LC-MS/MS) and non-compartmental pharmacokinetic analysis performed on concentration data from IV and oral administration. Serum concentrations of PBZ and its metabolites were below the limit of quantitation at 96 hours post administration. The volume of distribution at steady state, systemic clearance, and terminal half-life was 0.194 ± 0.019 L/kg, 23.9 ± 4.48 mL/h/kg, and 10.9 ± 5.32 hours, respectively. The terminal half-life following oral administration was 13.4 ± 3.01 (paste) and 15.1 ± 3.96 hours (tablets). Stimulation of PBZ treated whole blood with lipopolysaccharide and calcium ionophore resulted in an inhibition of TXB2 , PGE2 , LTB4 and 15-HETE production for a prolonged period of time post drug administration. The results of this study suggest that PBZ has a prolonged anti-inflammatory following IV or oral administration of 2 g to horses.
© 2018 John Wiley & Sons, Ltd.
eicosanoids; horse; inflammation; pharmacokinetics; phenylbutazone
Phenylbutazone blood and urine concentrations, pharmacokinetics, and effects on biomarkers of inflammation in horses following intravenous and oral administration of clinical doses.
Knych HK1,2, Arthur RM3, McKemie DS1, Seminoff K1, Hamamoto-Hardman B1, Kass PH4.
2019 Jun
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