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  • Brand : BIOFRON

  • Catalogue Number : BD-P0850

  • Specification : 98.0%(HPLC)

  • CAS number : 23451-01-6

  • Formula : C22H22O10

  • Molecular Weight : 446.408

  • PUBCHEM ID : 168938

  • Volume : 25mg

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Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

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For Reference Standard and R&D, Not for Human Use Directly.

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provides coniferyl ferulate(CAS#:23451-01-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

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Aromatase inhibitor (AI) resistance is a major obstacle in the treatment of estrogen receptor-positive breast cancer. Everolimus (EVE) ameliorates AI-resistant breast cancer and is therefore used in cancer treatment. However, some patients show resistance to EVE. Here, we used 30 clones of long-term estrogen-deprived (LTED) MCF-7 cells as a model of AI-resistant breast cancer. We examined changes in protein phosphatase type 2A (PP2A) and cancerous inhibitor of PP2A (CIP2A), a negative regulator of PP2A, in LTED cells treated with EVE. In LTED cells with high sensitivity to EVE, CIP2A expression decreased at low EVE concentrations; however, in LTED cells poorly sensitive to EVE, CIP2A and PP2A did not change upon exposure to EVE. Therefore, we hypothesized that there is a relation between expression of CIP2A and sensitivity to EVE. Knockdown of CIP2A increased the sensitivity to EVE in three clones poorly sensitive to EVE. Additionally, we found that treatment with FSK, which activates PP2A, increased the sensitivity of the cells to EVE. Our data point to CIP2A and PP2A as novel therapeutic targets for AI-resistant breast cancer.


everolimus, aromatase inhibitors resistance, long-term estrogen-deprived cells, PP2A, breast cancer


Forskolin increases the effect of everolimus on aromatase inhibitor-resistant breast cancer cells


Takanori Hayashi,1 Masahiro Hikichi,#2 Jun Yukitake,3 Toru Wakatsuki,4 Eiji Nishio,5 Toshiaki Utsumi,#2 and Nobuhiro Harada1

Publish date

2018 May 4;




This is the first article that the researcher is aware of that compares walking speed and confidence levels with 1 cane versus 2 canes. An observational study was conducted with 30 participants who had difficulty walking. Gait speed was assessed on a 4-m course with the participants using 1 cane, then 2 canes. Of 30 participants, 28 walked faster and demonstrated improved confidence with 2 canes. Use of 2 canes with gait might be a technique that people want to consider to improve confidence or to improve walking speed, or improve both.


confidence, gait speed, geriatrics


Gait Speed and Confidence Levels in Persons Using 1 and 2 Canes While Walking a 4-m Course


Marion A. Lisenby, MSPTcorresponding author

Publish date

2017 Apr;




United States and Canadian governments have responded to legal requirements to reduce human-induced whale mortality via vessel strikes and entanglement in fishing gear by implementing a suite of regulatory actions. We analyzed the spatial and temporal patterns of mortality of large whales in the Northwest Atlantic (23.5°N to 48.0°N), 1970 through 2009, in the context of management changes. We used a multinomial logistic model fitted by maximum likelihood to detect trends in cause-specific mortalities with time. We compared the number of human-caused mortalities with U.S. federally established levels of potential biological removal (i.e., species-specific sustainable human-caused mortality). From 1970 through 2009, 1762 mortalities (all known) and serious injuries (likely fatal) involved 8 species of large whales. We determined cause of death for 43% of all mortalities; of those, 67% (502) resulted from human interactions. Entanglement in fishing gear was the primary cause of death across all species (n = 323), followed by natural causes (n = 248) and vessel strikes (n = 171). Established sustainable levels of mortality were consistently exceeded in 2 species by up to 650%. Probabilities of entanglement and vessel-strike mortality increased significantly from 1990 through 2009. There was no significant change in the local intensity of all or vessel-strike mortalities before and after 2003, the year after which numerous mitigation efforts were enacted. So far, regulatory efforts have not reduced the lethal effects of human activities to large whales on a population-range basis, although we do not exclude the possibility of success of targeted measures for specific local habitats that were not within the resolution of our analyses. It is unclear how shortfalls in management design or compliance relate to our findings. Analyses such as the one we conducted are crucial in critically evaluating wildlife-management decisions. The results of these analyses can provide managers with direction for modifying regulated measures and can be applied globally to mortality-driven conservation issues.

Evaluacion del Manejo para Mitigar Efectos Antropogenicos sobre Ballenas Mayores

Los gobiernos de Estados Unidos y Canada han respondido a requerimientos legales para reducir la mortalidad de ballenas inducida por humanos por medio de impacto con embarcaciones y enmaraNamiento en artes de pesca mediante la implementacion de un conjunto de acciones reguladoras. Analizamos los patrones espaciales y temporales de la mortalidad de ballenas mayores en el Atlantico Noroccidental (23.5°N a 48.0°N), de 1970 a 2009, en el contexto de cambios de manejo. Utilizamos un modelo logistico multinomial ajustado por la maxima probabilidad de deteccion de tendencias en mortalidades por causa especifica en el tiempo. Comparamos el número de muertes provocadas por humanos con los niveles de remocion biologica potencial (i.e., mortalidad especifica provocada por humanos sustentable). De 1970 a 2009, hubo 1762 muertes (conocidas) y lesiones serias (casi fatales) involucrando 8 especies de ballenas mayores. Determinamos la causa de 43% de todas las muertes; de ellas, 67% (502) resultaron de interacciones humanas. El enmaraNamiento en artes de pesca fue la causa principal de muerte en todas las especies (n = 323), seguida de causas naturales (n = 248) e impacto de embarcaciones (n = 171). Los niveles sustentables de mortalidad establecidos fueron excedidos consistentemente hasta en 650% en 2 especies. Las probabilidades de muerte por enmaraNamiento y por impacto de embarcaciones incrementaron significativamente de 1990 a 2009. No hubo cambio significativo en la intensidad local de mortalidad por todas las causas o por impacto de embarcaciones antes y despues de 2003, aNo en el que se implementaron numerosos esfuerzos de mitigacion. Hasta ahora, los esfuerzos regulatorios no han reducido los efectos letales de las actividades humanas sobre las ballenas a nivel de poblacion, aunque no excluimos la posibilidad de exito de medidas enfocadas a habitats locales especificos que no estuvieron dentro de la resolucion de nuestro analisis. No es claro como se relacionan con nuestros resultados las deficiencias en el diseNo o implementacion del manejo. Analisis como el que realizamos son cruciales para la evaluacion critica de decisiones para el manejo de vida silvestre, y los resultados de estos analisis pueden proporcionar directrices a los manejadores para que modifiquen medidas regulatorias y puedan ser aplicadas globalmente en temas de conservacion relacionadas con mortalidad.


entanglement, evaluation of management/mitigation efforts, human-interaction, large whales, mortality, necropsy, vessel-strike, Ballenas mayores, enmaraNamiento, evaluacion de esfuerzos de manejo/mitigacion, impacto con embarcaciones, interaccion humana, mortalidad, necropsia


Assessment of Management to Mitigate Anthropogenic Effects on Large Whales


Julie M Van Der Hoop,*† Michael J Moore,* Susan G Barco,‡ Timothy VN Cole,§ Pierre-Yves Daoust,** Allison G Henry,§ Donald F McAlpine,†† William A McLellan,‡‡ Tonya Wimmer,§§ and Andrew R Solow***

Publish date

2013 Feb