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Physcion

$85

  • Brand : BIOFRON

  • Catalogue Number : BF-P1006

  • Specification : 98%

  • CAS number : 521-61-9

  • Formula : C16H12O5

  • Molecular Weight : 284.27

  • PUBCHEM ID : 10639

  • Volume : 20mg

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Catalogue Number

BF-P1006

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

284.27

Appearance

Orange needle crystal

Botanical Source

Morinda officinalis,Spatholobus suberectus,Rheum palmatum,Reynoutria japonica,Bletilla striata

Structure Type

Alkaloids

Category

Standards;Natural Pytochemical;API

SMILES

CC1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=C(C=C3O)OC

Synonyms

1,8-dihydroxy-3-methoxy-6-methylanthracene-9,10-dione/Emodin 3-methyl ether/Emodin monomethyl ether/9,10-Anthracenedione, 1,8-dihydroxy-3-methoxy-6-methyl-/Parietin/Methoxyemodin/1,8-Dihydroxy-3-methoxy-6-methyl-9,10-anthracenedione/Emodin-3-methyl ether/Rheochrysidin/physicion/phycion/1,8-Dihydroxy-3-methoxy-6-methyl-9,10-anthraquinone/Physcion/1,8-Dihydroxy-3-methoxy-6-methylanthraquinone,Emodin-3-methyl ether/1,8-Dihydroxy-3-methoxy-6-methylanthraquinone/1,8-dihydroxy-5-methyl-3-methoxy-9,10-anthraquinone/Physcione

IUPAC Name

1,8-dihydroxy-3-methoxy-6-methylanthracene-9,10-dione

Density

1.4±0.1 g/cm3

Solubility

Methanol; Acetone; DMF

Flash Point

215.4±23.6 °C

Boiling Point

560.5±50.0 °C at 760 mmHg

Melting Point

196-206°C

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2914690000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:521-61-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

31226286

Abstract

Anthraquinones constitute an important class of natural and synthetic compounds with a broad scope of pharmacological including anti-bacterial, antioxidant, laxative, anti-tumor and other activities. Physcion and physcion 8-O-β-glucopyranoside (PG) are common anthraquinones existed in various plants. Emerging studies suggested that physcion and PG not only exert anti-tumor, anti-microbial, anti-inflammatory, anti-oxidant, optical-related, enzyme inhibitory, lipid regulation and neuroprotective activities, but also lead to hepatotoxicity, renal toxicity and genetic damage. Besides, a growing number of pharmacokinetics researches of physcion and PG also have been conducted. However, no review of physcion or PG have been published by now, so the aim of present review is to give a comprehensive summary and analysis of the pharmacology, toxicity and pharmacokinetics of physcion and PG by consulting all the currently available literatures published in PubMed then give a future prospects about it.

Copyright © 2019 Elsevier B.V. All rights reserved.

KEYWORDS

Pharmacokinetics; Pharmacology; Physcion; Physcion 8-O-β-glucopyranoside; Toxicity

Title

Physcion and physcion 8-O-β-glucopyranoside: A review of their pharmacology, toxicities and pharmacokinetics.

Author

XunLi1, Liu Y1, Chu S2, Yang S1, Peng Y1, Ren S1, Wen B1, Chen N3.

Publish date

2019 Sep 1

PMID

29710489

Abstract

Hepatocellular carcinoma (HCC) is one of the most common and aggressive malignancies. The current study aimed to investigate the effect of physcion, a major active ingredient in several traditional herbal medicinal plants, for the treatment of HCC. Our data showed that physcion markedly induced apoptosis in human HCC cell lines Huh7 and Bel7402. The pro-apoptotic role of physcion on HCC cells was mediated by mitochondria dysfunction, which was caused by activation of endoplasmic reticulum(ER) stress. Moreover, our findings revealed that physcion stimulated ER stress by activating AMPK signaling. Besides in HCC cell lines, the anti-cancer activity of physcion was also examined in a xenograft mice model, which showed that physcion could significantly suppressed tumor growth. In conclusion, our results indicated that physcion can be considered as a potential chemotherapeutic agent in the treatment of HCC.

Copyright © 2018 Elsevier Masson SAS. All rights reserved.

KEYWORDS

AMPK; ER stress; HCC; Key words; Physcion

Title

Physcion induces apoptosis through triggering endoplasmic reticulum stress in hepatocellular carcinoma.

Author

Pan XP1, Wang C2, Li Y2, Huang LH3.

Publish date

2018 Mar

PMID

31359665

Abstract

To evaluate the hepatotoxicity risks of physcion on the basis of the bilirubin metabolism mediated by glucuronidation of UDP-glucuronosyltransferases 1A1(UGT1A1 enzyme). The monomers were added into the rat liver microsomes to test the hepatotoxicity by using bilirubin as UGT1A1 enzyme substrate, with apparent inhibition constant K_i as the evaluation index. Liver microsome incubation in vitro was adopted to initiate phase Ⅱ metabolic reaction and investigate the inhibitory effect of physcion. Then the phase Ⅰ and Ⅱ metabolic reactions were initiated to investigate the comprehensive inhibition of metabolites and prototype components. The results showed that when only the phase Ⅱ reaction was initiated, physcion directly acted on the UGT1A1 enzyme in a prototype form, exhibited weak inhibition and the inhibition type was mixed inhibition; When the phase Ⅰ and Ⅱ reactions were initiated simultaneously, the inhibitory effects of physcion on UGT1A1 enzyme became strong and the inhibition type was mixed inhibition, suggesting that physcion had phase Ⅰ and Ⅱ metabolic processes, and the metabolites had strong inhibitory effect on UGT1A1 enzyme. This experiment preliminarily proved that the metabolites of physcion may be the main components to induce hepatotoxicity.

KEYWORDS

UGT1A1 enzyme; metabolite; phase Ⅰ metabolism; phase Ⅱ metabolism; physcion

Title

[Study on hepatotoxicity of physcion based on liver metabolism in vitro].

Author

Wang Q1, Wang YD1, Yang JB1, Liu Y1, Wen HR1, Ma SC1.

Publish date

2019 Jun


Description :

Physcion (Parietin) is an anthraquinone isolated from traditional Chinese medicine Radix et Rhizoma Rhei, acts as an inhibitor of 6-phosphogluconate dehydrogenase, with an IC50 and a Kd of 38.5 μM and 26.0 μM, respectively[1][2]. Physcion (Parietin) exhibits laxative, hepatoprotective, anti-inflammatory, anti-microbial, anti-proliferative and anti-tumor effects[2].