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Phytol

$72

  • Brand : BIOFRON

  • Catalogue Number : BD-D1244

  • Specification : 94%(HPLC)

  • CAS number : 150-86-7

  • Formula : C20H40O

  • Molecular Weight : 296.5

  • Volume : 0.1ml

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Catalogue Number

BD-D1244

Analysis Method

HPLC,NMR,MS

Specification

94%(HPLC)

Storage

-20?

Molecular Weight

296.5

Appearance

Oil

Botanical Source

Structure Type

Aliphatic Compounds/Diterpenoids

Category

SMILES

CC(C)CCCC(C)CCCC(C)CCCC(=CCO)C

Synonyms

IUPAC Name

Applications

Density

0.8±0.1 g/cm3

Solubility

DMSO : 125 mg/mL (421.54 mM; Need ultrasonic)

Flash Point

157.5±8.9 °C

Boiling Point

335.5±0.0 °C at 760 mmHg

Melting Point

InChl

InChI=1S/C20H40O/c1-17(2)9-6-10-18(3)11-7-12-19(4)13-8-14-20(5)15-16-21/h15,17-19,21H,6-14,16H2,1-5H3/b20-15+/t18-,19-/m1/s1

InChl Key

BOTWFXYSPFMFNR-PYDDKJGSSA-N

WGK Germany

RID/ADR

HS Code Reference

2905220000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:150-86-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

32123083

Abstract

Cyanobacteria are unicellular prokaryotic algae that perform oxygenic photosynthesis, similar to plants. The cells harbor thylakoid membranes composed of lipids related to those of chloroplasts in plants to accommodate the complexes of photosynthesis. The occurrence of storage lipids, including triacylglycerol or wax esters, which are found in plants, animals, and some bacteria, nevertheless remained unclear in cyanobacteria. We show here that the cyanobacterium Synechocystis sp. PCC6803 accumulates both triacylglycerol and wax esters (fatty acid phytyl esters). Phytyl esters accumulate in higher levels under abiotic stress conditions. The analysis of an insertional mutant revealed that the acyltransferase slr2103, with sequence similarity to plant esterase/lipase/thioesterase (ELT) proteins, is essential for triacylglycerol and phytyl ester synthesis in Synechocystis The recombinant slr2103 enzyme showed acyltransferase activity with phytol and diacylglycerol, thus producing phytyl esters and triacylglycerol. Acyl-CoA thioesters were the preferred acyl donors, while acyl-ACP (acyl carrier protein), free fatty acids, or galactolipid-bound fatty acids were poor substrates. The slr2103 protein sequence is unrelated to acyltransferases from bacteria (AtfA) or plants (DGAT1, DGAT2, PDAT), and therefore establishes an independent group of bacterial acyltransferases involved in triacylglycerol and wax ester synthesis. The identification of the gene slr2103 responsible for triacylglycerol synthesis in cyanobacteria opens the possibility of using prokaryotic photosynthetic cells in biotechnological applications.

KEYWORDS

acyltransferase; cyanobacteria; triacylglycerol; wax.

Title

Triacylglycerol and phytyl ester synthesis in Synechocystis sp. PCC6803

Author

Mohammed Aizouq 1, Helga Peisker 1, Katharina Gutbrod 1, Michael Melzer 2, Georg Holzl 1, Peter Dormann 3

Publish date

2020 Mar 17;

PMID

31818004

Abstract

Sargassum horneri; fucosterol; high-speed counter-current chromatography; phytol; preparative separation; saringosterol.

KEYWORDS

Sargassum horneri; fucosterol; high-speed counter-current chromatography; phytol; preparative separation; saringosterol.

Title

One-Step Preparative Separation of Phytosterols from Edible Brown Seaweed Sargassum horneri by High-Speed Countercurrent Chromatography

Author

Menglu Xia 1, Chunping Liu 1, Lei Gao 2, Yanbin Lu 1

Publish date

2019 Dec 9

PMID

31734340

Abstract

Amyloid ? (A?) induced neurotoxicity has been postulated to initiate synaptic loss and subsequent neuronal degeneration in Alzheimer’s disease (AD). The nanoparticles based drug carrier system is considered as a promising therapeutic strategy to combat this incurable disease. It was also found to inhibit cholinesterase activity and apoptosis mediated cell death in Neuro-2a cells. The in vivo study further revealed that the Phytol and Phytol-PLGA NPs (Poly Lactic-co-Glycolic Acid Nanoparticles) was found to increase the lifespan, chemotaxis behavior and decrease A? deposition & ROS (Reactive oxygen species) production in transgenic Caenorhabditis elegans models of AD (CL2006, CL4176). Phytol and Phytol-PLGA NPs treatment downregulated the expression of AD associated genes viz A?, ace-1 and hsp-4 and upregulated the gene involved in the longevity to nematodes (dnj-14) and it also reduced the expression of A? peptide at the protein level. Our results of in vitro and in vivo studies suggest that Phytol and Phytol-PLGA NPs hold promising neuroprotective efficacy and targets multiple neurotoxic mechanisms involved in the AD progression.

KEYWORDS

Alzheimer's disease; Amyloid ?; Neuro-2a cells; Phytol; Phytol-PLGANPs; Transgenic Caenorhabditis elegans.

Title

Phytol loaded PLGA nanoparticles regulate the expression of Alzheimer's related genes and neuronal apoptosis against amyloid-? induced toxicity in Neuro-2a cells and transgenic Caenorhabditis elegans

Author

Sethuraman Sathya 1, Balakrishnan Shanmuganathan 1, Boopathi Balasubramaniam 1, Krishnaswamy Balamurugan 1, Kasi Pandima Devi 2

Publish date

2020 Feb