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Picfeltarraenin IB

$250

  • Brand : BIOFRON

  • Catalogue Number : BF-P4011

  • Specification : 99%(HPLC)

  • CAS number : 97230-46-1

  • Formula : C42H64O14

  • Molecular Weight : 792.95

  • PUBCHEM ID : 102120501

  • Volume : 25mg

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Catalogue Number

BF-P4011

Analysis Method

HPLC,NMR,MS

Specification

99%(HPLC)

Storage

2-8°C

Molecular Weight

792.95

Appearance

White crystalline powder

Botanical Source

Picria felterrae

Structure Type

Terpenoids

Category

Standards;Natural Pytochemical;API

SMILES

CC1C(C(C(C(O1)OC2C(C(C(OC2OC3CCC4C(=CCC5C4(C(=O)CC6(C5(CC(C6C7(C(=O)C=C(O7)C(C)C)C)O)C)C)C)C3(C)C)CO)O)O)O)O)O

Synonyms

(1R,4R,9β,16α)-16-Hydroxy-9,10,14-trimethyl-11,22-dioxo-20,24-epoxy-4,9-cyclo-9,10-secocholesta-5,23-dien-1-yl 2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside/(1R,4R,9β,16α)-16-Hydroxy-9,10,14-trimethyl-11,22-dioxo-21,24-epoxy-4,9-cyclo-9,10-secocholesta-5,23-dien-1-yl 2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside/19-Norlanosta-5,23-diene-11,22-dione, 3-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-20,24-epoxy-16-hydroxy-9-methyl-, (3α,9β,10α,16α)-/Estr-5-en-11-one, 3-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-17-[(3R)-3,4-dihydro-6-(1-methylethyl)-4-oxo-2H-pyran-3-yl]-16-hydroxy-4,4,9,14-tetramethyl-, (3α,9β,10alph ; a,16α,17β)-/estr-5-en-11-one, 3-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-17-[(2R)-2,3-dihydro-2-methyl-5-(1-methylethyl)-3-oxo-2-furanyl]-16-hydroxy-4,4,9,14-tetramethyl-, (3α,9β,10α,16α,17β)-/Estr-5-en-11-one, 3-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-17-[(2R)-2,3-dihydro-2-methyl-5-(1-methylethyl)-3-oxo-2-furanyl]-16-hydroxy-4,4,9,14-tetramethyl-, (3α,9β,1 ; 0α,16α,17β)-

IUPAC Name

(2R)-2-[(3R,8S,9R,10R,13R,14S,16R,17R)-3-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-16-hydroxy-4,4,9,13,14-pentamethyl-11-oxo-1,2,3,7,8,10,12,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl]-2-methyl-5-propan-2-ylfuran-3-one

Density

1.4±0.1 g/cm3

Solubility

Methanol; Ethyl Acetate

Flash Point

264.0±27.8 °C

Boiling Point

895.7±65.0 °C at 760 mmHg

Melting Point

InChl

InChI=1S/C42H64O14/c1-18(2)23-14-26(45)42(9,56-23)35-22(44)15-39(6)25-12-10-20-21(41(25,8)27(46)16-40(35,39)7)11-13-28(38(20,4)5)54-37-34(32(50)30(48)24(17-43)53-37)55-36-33(51)31(49)29(47)19(3)52-36/h10,14,18-19,21-22,24-25,28-37,43-44,47-51H,11-13,15-17H2,1-9H3/t19-,21+,22+,24+,25-,28+,29-,30+,31+,32-,33+,34+,35-,36-,37-,39-,40+,41-,42-/m0/s1

InChl Key

YRQJYHITIWJZQN-UGBBSPHQSA-N

WGK Germany

RID/ADR

HS Code Reference

2938900000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:97230-46-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

26690256

Abstract

A simple and rapid quantitative UPLC-MS/MS method for simultaneous determination of picfeltarraenins IA and IB in rat plasma was developed and validated in accordance with the US FDA Bioanalytical Guidance (2001). Analytes were extracted from rat plasma by using methanol and separated on Agilent ZORBAX SB-C18 (50mm×2.1mm, 1.8μm) column by using a mobile phase composed of methanol and water (70:30, v/v). Eluents were monitored by ESI tandem mass spectrometry detection with SRM mode using ion transitions m/z 785.4→639.5, m/z 815.5→669.5, and m/z 763.5→455.3 for picfeltarraenin IA, picfeltarraenin IB, and internal standard, respectively. The method was validated over the linear range of 11.5-1150ng/mL and 13.0-1300ng/mL. The developed analytical method was applied to support a pharmacokinetic study on simultaneous estimation of picfeltarraenins IA and IB in rats.

Copyright © 2015 Elsevier B.V. All rights reserved.

KEYWORDS

Pharmacokinetic study; Picfeltarraenins; Triterpenoid saponins; UPLC-MS/MS

Title

Simultaneous quantification of picfeltarraenins IA and IB in rat plasma by UPLC-MS/MS: Application to a pharmacokinetic study.

Author

He X1, Zhang Y1, Gao H1, Li K1, Zhang Y1, Sun L1, Tao G2.

Publish date

2016 Feb 20


Description :

Picfeltarraenin IB, a triterpenoid obtained from Picriafel-terrae Lour (P.fel-terrae), is an acetylcholinesterase (AChE) inhibitor. Picfeltarraenin IB can be used for the treatment of herpes infections, cancer and inflammation[1].