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Picrasidine Q

$1,440

  • Brand : BIOFRON

  • Catalogue Number : BN-O1755

  • Specification : 98%(HPLC)

  • CAS number : 101219-61-8

  • Formula : C15H10N2O3 

  • Molecular Weight : 266.3

  • PUBCHEM ID : 54714262

  • Volume : 5mg

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Catalogue Number

BN-O1755

Analysis Method

Specification

98%(HPLC)

Storage

-20℃

Molecular Weight

266.3

Appearance

Yellow powder

Botanical Source

This product is isolated and purified from the bark of Picrasma quassioides.

Structure Type

Category

SMILES

COC1=C(C2=NC=CC3=C2N(C1=O)C4=CC=CC=C34)O

Synonyms

5-methoxy-4-hydroxycanthin-6-one/picrasidine Q/4-Hydroxy-5-methoxy-indolo[3,2,1-de][1,5]naphthyridin-6-one/4-hydroxy-5-methoxycanthin-6-one

IUPAC Name

Density

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

Boiling Point

Melting Point

InChl

InChl Key

HJFNTSGIQCFHGP-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:101219-61-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

28857247

Abstract

Fibroblast growth factor receptor (FGFR) 2 and its downstream signaling cascades, PI3 K/AKT/mTOR is playing an important role in cell survival and proliferations. In this study, we firstly found that picrasidine Q (PQ), an alkaloid component extracted from Angelica keiskei species, has the capacity of anti-cell transformation and anti-cancer. After ligand shape similarity approach of PQ, we found that PQ targeted FGFR 2 and verified by FGFR2 kinase assay as well as computational docking model. FGFR2 highly expressed in esophageal cancer tissues and PQ inhibited fibroblast growth factor (FGF)-induced cell transformation. Furthermore, PQ inhibited cell proliferation and induced cell cycle arrest and apoptosis in KYSE30, KYSE410, and KYSE450 esophageal squamous cell carcinoma (ESCC) cells. It was confirmed by detecting of biological markers such as cyclinD1, cyclinD3 and cyclinB1 for cell cycle or cleaved caspase-7, caspase-3, and PARP for apoptosis. PQ targeting of FGFR2 kinase activities suppressed downstream target proteins including phosphorylation of AKT and mTOR but not MEK/ERK signaling pathways. Taken together, our results are the first to identify that PQ might be a chemopreventive and chemotherapeutic agent by direct targeting FGFR2 and inhibiting cell proliferation of ESCC cells.

© 2017 Wiley Periodicals, Inc.

KEYWORDS

AKT/mTOR signaling pathways; FGFR2; esophageal squamous cell carcinoma; picrasidine Q (PQ)

Title

FGFR2 regulation by picrasidine Q inhibits the cell growth and induces apoptosis in esophageal squamous cell carcinoma.

Author

Shi Y1, Liu X1, Fredimoses M1, Song M1,2, Chen H3, Liu K1,2, Lee MH1, Dong Z1,3.

Publish date

2018 Feb


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