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Pimpinellin

$185

  • Brand : BIOFRON

  • Catalogue Number : BD-P0765

  • Specification : 98.5%(HPLC&TLC)

  • CAS number : 131-12-4

  • Formula : C13H10O5

  • Molecular Weight : 246.2

  • PUBCHEM ID : 4825

  • Volume : 25mg

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Catalogue Number

BD-P0765

Analysis Method

Specification

98.5%(HPLC&TLC)

Storage

-20℃

Molecular Weight

246.2

Appearance

Yellow powder

Botanical Source

This product is isolated and purified from the fruits of Psoralea corylifolia L.

Structure Type

Category

SMILES

COC1=C(C2=C(C=CO2)C3=C1C=CC(=O)O3)OC

Synonyms

5,6-Dimethoxy-2H-furo[2,3-h]chromen-2-one/2H-Furo[2,3-h]-1-benzopyran-2-one, 5,6-dimethoxy-/5,6-dimethoxyfuro[2,3-h]chromen-2-one/4-Hydroxy-6,7-dimethoxy-5-benzofuranacrylic Acid d-Lactone/5,6-Dimethoxy-2H-furo[2,3-h]-1-benzopyran-2-one/Pimpinellin

IUPAC Name

Applications

Discovery and antitumor activities of constituents from Cyrtomium fortumei (J.) Smith rhizomes.[Pubmed: 23379693 ]Chem Cent J. 2013 Feb 4;7(1):24. Cyrtomium fortumei (J.) Smith is an important Chinese herbal medicine because of its biological functions. However, systematic and comprehensive studies on the phytochemicals from Cyrtomium fortumei (J.) Smith and their bioactivity are limited. METHODS AND RESULTS: Using the bioassay-guided technique, the ethyl acetate and n-BuOH extracts of the rhizomes of Cyrtomium fortumei (J.) Smith were shown to exhibit good antitumor activities, consequently leading to the isolation of 23 compounds. All compounds were isolated from the plant for the first time. The inhibitory activities of these compounds were investigated on tumor cells MGC-803, PC3, and A375 in vitro by MTT (thiazolyl blue tetrazolium bromide) assay, and the results showed that Pimpinellin (3) had potent cytotoxic activities against the three cell lines, with the IC50 values of 14.4 ± 0.3 μM, 20.4 ± 0.5 μM, and 29.2 ± 0.6 μM, respectively. The mechanism of the antitumor action indicated that Pimpinellin inhibited the growth of MGC-803 cells via the induction of tumor cell apoptosis, with apoptosis ratio of 27.44% after 72 h of treatment at 20 μM. CONCLUSIONS: This study suggests that most of the compounds from the roots of Cyrtomium fortumei (J.) Smith could inhibit the growth of human carcinoma cells. Moreover, Pimpinellin inhibited the growth of tumor cells via the induction of tumor cell apoptosis.

Density

1.4±0.1 g/cm3

Solubility

Methanol

Flash Point

220.5±28.7 °C

Boiling Point

441.0±45.0 °C at 760 mmHg

Melting Point

119°

InChl

InChl Key

BQPRWZCEKZLBHL-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:131-12-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

No Article Available.