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Piscidinol A

$800

  • Brand : BIOFRON

  • Catalogue Number : BN-O1813

  • Specification : 98%(HPLC)

  • CAS number : 100198-09-2

  • Formula : C30H50O4

  • Molecular Weight : 474.72

  • PUBCHEM ID : 12004524

  • Volume : 5mg

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Catalogue Number

BN-O1813

Analysis Method

Specification

98%(HPLC)

Storage

-20℃

Molecular Weight

474.72

Appearance

Powder

Botanical Source

This product is isolated and purified from the bark of Phellodendron chinense

Structure Type

Category

SMILES

CC(CC(C(C(C)(C)O)O)O)C1CCC2(C1(CCC3C2=CCC4C3(CCC(=O)C4(C)C)C)C)C

Synonyms

Pyruvicacid phenylhydrazone/2-Phenylhydrazono-propionsaeure/2-phenylhydrazono-propionic acid/Brenztraubensaeure-phenylhydrazon/piscidinol A/(13α,14β,17α,20S,23R,24S)-23,24,25-Trihydroxylanost-7-en-3-one/3-oxo-threo-23,24,25-trihydroxytirucall-7-ene/Lanost-7-en-3-one, 23,24,25-trihydroxy-, (13α,14β,17α,20S,23R,24S)-/piruvic acid phenylhydrazone/pyruvate phenylhydrazone

IUPAC Name

Applications

Density

1.1±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

330.3±26.6 °C

Boiling Point

599.4±50.0 °C at 760 mmHg

Melting Point

InChl

InChl Key

DCGUKHULKAAOPB-QBLSGNHRSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:100198-09-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

26456550

Abstract

Four types of piscidinol A derivatives were synthesized and evaluated their ability to inhibit HIV-1 protease to understand their structure-activity relationships. Of these tirucallane-type triterpene derivatives, an A-seco derivative (1b) moderately inhibited human immunodeficiency virus (HIV) protease (IC50 38.2 μM). The 2,2-dimethyl succinic acid (DMS) acylated tirucallane derivatives (4b, 6a, and 7b, 50 < IC50 < 100 μM) were more inhibitory against HIV-1 PR than the others (PA, 2a, 4a, 4c-4d, 5a, 6b-6d, and 7a, IC50 > 100 μM). These findings indicated that the 2,3-seco-2,3-dioic acid (1b) and DMS-acylated tirucallane-type derivatives preferably inhibited HIV viral protease.

KEYWORDS

A-ring modified derivatives; HIV-1 protease; bi-acylated derivatives; mono-acylated derivatives; multi-acylated derivatives; piscidinol A

Title

Synthesis of piscidinol A derivatives and their ability to inhibit HIV-1 protease.

Author

Wei Y1, Ma CM2, Jiang TB1, Du J1, Zhou X3, Liu GQ1, Hattori M4.

Publish date

2015