White crystalline powder
Cynomorium songaricum,Reynoutria japonica,Cyperus rotundus,Boehmeria nivea,Lysidice brevicalyx
Resveratrol 3-O-glucoside/3-Hydroxy-5-[2-(4-hydroxyphenyl)ethenyl]phenyl-b-D-glucopyranoside/β-D-Glucopyranoside, 3-hydroxy-5-(2-(4-hydroxyphenyl)ethenyl)phenyl/trans-polydatin/3-Hydroxy-5-(p-hydroxystyryl)phenyl Glucoside/β-D-Glucopyranoside, 3-hydroxy-5-[(E)-2-(4-hydroxyphenyl)ethenyl]phenyl/3-hydroxy-5-[(E)-2-(4-hydroxyphenyl)ethenyl]phenyl β-D-glucopyranoside/Piceid/trans-Piceid/Resveratrol 3-Glucoside/Polydotin peceid/Pieceid/Plydatin/4',5-Dihydroxystilben-3-yl β-D-Glucopyranoside/Resveratrol-3-b-mono-D-glucoside/3,4',5-Trihydroxystilbene-3-b-glucoside/3-Hydroxy-5-[(E)-2-(4-hydroxyphenyl)vinyl]phenyl β-D-glucopyranoside/RESVERATROL GLUCOSIDE/Polydatin
707.7±60.0 °C at 760 mmHg
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provides coniferyl ferulate(CAS#:27208-80-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
Polydatin (PD), a monocrystalline polyphenolic drug mainly found in the roots of Polygonum cuspidatum, has various pharmacological activities. Long non-coding RNAs (lncRNA) DiGeorge syndrome critical region gene 5 (DGCR5) was found to participate in the suppression of multiple cancers. Here, we proposed to study the effect of PD on myocardial infarction (MI) by inducing DGCR5. CCK-8 assay was performed to detect the viability of H9c2 cells. Flow cytometry was utilized to test apoptosis of H9c2 cells. These results determined the optimal concentration and effect time of hypoxia as well as PD. Si-DGCR5 was transfected into cells and the expression level was determined by qRT-PCR. Western blot was utilized to evaluate the expression of apoptosis-related proteins, Bcl-2, Bax, and cleaved-caspase-3, as well as autophagy-associated proteins including Beclin-1, p62, and LC3-II/LC3-I. As a result, PD efficiently attenuated hypoxia-induced apoptosis and autophagy in H9c2 cells. The expression of DGCR5 was down-regulated by hypoxia and up-regulated by PD. Besides, knocking-down the expression of DGCR5 inhibited the protection of PD in H9c2 cells. In addition, PD up-regulated the accumulation of DGCR5, DGCR5 decreased the expression of Bcl-2 and p62, raised the expression of Bax and cleaved-caspase-3, and the proportion of LC3-II/LC3-I. PD stimulated the PI3K/AKT/mTOR and MEK/ERK signaling pathways via up-regulating the expression of DGCR5. Our data demonstrated that PD reduced cell apoptosis and autophagy induced by hypoxia in cardiomyocytes. Moreover, PD activated PI3K/AKT/mTOR and MEK/ERK signaling pathways by up-regulating the expression of DGCR5.
Polydatin protects H9c2 cells from hypoxia-induced injury via up-regulating long non-coding RNA DGCR5.
Dai J1, Ma J1, Liao Y1, Luo X2, Chen G3.
2019 Dec 5;52
Graves’ orbitopathy (GO) is a sight-threatening ocular disease that occurs in patients with hyperthyroidism and is especially associated with oxidative stress. Polydatin (PD) is a major active component of Polygonum cuspidatum Sieb. et Zucc. It has various therapeutic effects including anti-inflammatory and antioxidant properties. In the present study, we investigated the effects of PD on H2O2-induced oxidative stress in orbital fibroblasts in vitro and in a GO mouse model of orbital oxidative stress in vivo. The mechanisms responsible for these effects were investigated using standard molecular techniques. Our initial findings in GO mice were that PD attenuated orbital muscle adipose tissue expansion and lipid droplet accumulation through a nuclear factor E2-related factor 2 (NRF2)-mediated oxidative stress response involving the Keap1/Nrf2/ARE pathway. The results demonstrated that PD could reverse the accumulation of lipid droplets and production of reactive oxygen species (ROS) induced by H2O2 and increase the expression of antioxidant genes such as NAD(P)H dehydrogenase, quinone 1 (NQO1). NQO1 levels were the lowest in the GO mouse model. In addition, PD enhanced NRF2 nuclear translocation in cultured orbital fibroblasts. We also found that silencing NRF2, using RNA interference, reduced the protective effects of PD against H2O2-induced oxidative stress in orbital fibroblasts in vitro. Taken together, our results indicate that PD can reduce the production of ROS and inhibit adipogenesis in orbital fibroblasts in vitro and in vivo.
Copyright © 2019 Elsevier B.V. All rights reserved.
Graves' orbitopathy; NRF2; Oxidative stress; Polydatin
Polydatin attenuates orbital oxidative stress in Graves' orbitopathy through the NRF2 pathway.
Li H1, Min J2, Chen Y2, Li H2, Zhang Y2.
2020 Jan 5
The cultivated grapevine V. vinifera is a rich source of stilbene compounds such as resveratrol, which are widely believed to provide dietary protection against the development of cardiovascular disease and some forms of cancer. Elicitation is a well-known strategy to increase commercial production of natural products in plant cell suspension culture systems. Callus tissues obtained from berry slices of V. vinifera cv. Shahani grown on an optimized medium were used to develop cell suspension cultures used to study the effects of elicitation on stilbene synthesis. The effect of two light regimes (135.1 μmol. s-1 m-2 radiation, and dark), the concentration of phenylalanine (Phe; 0, 0.1, 0.5 and 1 mM) and of methyl jasmonate elicitor (MeJA; 0 and 25 μM), alone or in combination, were tested. The results showed that cultures grown in darkness resulted in significantly higher levels of the accumulation of total stilbenes (resveratrol + piceid) compared with the high light condition. The combined treatments of dark +1 mM Phe and dark +25 μM MeJA induced the synthesis of high levels of total phenolics, total flavonoids and total stilbenes. Finally, the combined elicitation of dark +1 mM Phe + 25 μM MeJA gave the highest synergistic coefficient (1.24) and proved to be the most effective treatment for the production of total phenolics, total flavonoids, and total stilbenes with mean contents of 384.80 mg GA/g DW, 527.62 mg catechin/g DW and 188.34 μg/g DW, respectively. The results of our study suggest that the combinations of dark together with MeJA and/or Phe can be used as an efficient method for the future scale-up of V. vinifera cell cultures for the production of high value stilbene compounds in a bioreactor system.
Copyright © 2019 Elsevier B.V. All rights reserved.
Dark; Elicitation; Methyl jasmonate; Phenylalanine; Stilbene compounds; Vitis vinifera
The effect of light, phenylalanine and methyl jasmonate, alone or in combination, on growth and secondary metabolism in cell suspension cultures of Vitis vinifera.
Andi SA1, Gholami M2, Ford CM3, Maskani F2.
Polydatin (Piceid), extracted from the roots of Polygonum cuspidatum Sieb, a widely used traditional Chinese remedies, possesses anti-inflammatory activity in several experimental models.