Polygala senega and Polygala tenuifolia
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provides coniferyl ferulate(CAS#:79103-90-5) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
The crystal structures of two hydrogen-bonded compounds, namely 4-methoxybenzoic acid-1,3-bis(pyridin-4-yl)propane (2/1), C13H14.59N2·C8H7.67O3·C8H7.74O3, (I), and biphenyl-4,4′-dicarboxylic acid-4-methoxypyridine (1/2), C14H9.43O4·C6H7.32NO·C6H7.25NO, (II), have been determined at 93 K. In (I), the asymmetric unit consists of two crystallographically independent 4-methoxybenzoic acid molecules and one 1,3-bis(pyridin-4-yl)propane molecule. The asymmetric unit of (II) comprises one biphenyl-4,4′-dicarboxylic acid molecule and two independent 4-methoxypyridine molecules. In each crystal, the acid and base molecules are linked by short O—H⋯N/N—H⋯O hydrogen bonds, in which H atoms are disordered over the acid O-atom and base N-atom sites, forming a linear hydrogen-bonded 2:1 or 1:2 unit of the acid and the base. The 2:1 units of (I) are linked via C—H⋯π, π-π and C—H⋯O interactions into a tape structure along , while the 1:2 units of (II) form a double-chain structure along [-101] through π-π and C—H⋯O interactions.
crystal structure, 4-methoxybenzoic acid, 1,3-bis(pyridin-4-yl)propane, biphenyl-4,4′-dicarboxylic acid, 4-methoxypyridine
Crystal structures of 4-methoxybenzoic acid-1,3-bis(pyridin-4-yl)propane (2/1) and biphenyl-4,4′-dicarboxylic acid-4-methoxypyridine (1/2)
Kazuma Gotoha and Hiroyuki Ishidaa,*
2017 Jul 1;
Telomerase is the ribonucleoprotein reverse transcriptase involved in the maintenance of the telomeres, the termini of eukaryotic chromosomes. The RNA component of human telomerase (hTR) consists of 451 nucleotides with the 5′ half folding into a highly conserved catalytic core comprising the template region and an adjacent pseudoknot domain (nucleotides 1-208). While the secondary structure of hTR is established, there is little understanding of its three-dimensional (3D) architecture. Here, we have used fluorescence resonance energy transfer (FRET) between fluorescently labelled peptide nucleic acids, hybridized to defined single stranded regions of full length hTR, to evaluate long-range distances. Using molecular modeling, the distance constraints derived by FRET were subsequently used, together with the known secondary structure, to generate a 3D model of the catalytic core of hTR. An overlay of a large set of models generated has provided a low-resolution structure (6.5-8.0 a) that can readily be refined as new structural information becomes available. A notable feature of the modeled structure is the positioning of the template adjacent to the pseudoknot, which brings a number of conserved nucleotides close in space.
Structural Analysis of the Catalytic Core of Human Telomerase RNA by FRET and Molecular Modeling†,‡
Gerald Gavory,▽∥ Martyn F. Symmons,§∥ Yamuna Krishnan Ghosh,▽ David Klenerman,▽ and Shankar Balasubramanian*▽
2008 Jan 14.
A whole-blood flow cytometry-based assay was utilized to assess CD4 and CD8 T-lymphocyte activation in response to phytohemagglutinin (PHA) stimulation. T-lymphocyte activation was assessed by qualitative (percent CD69) and semiquantitative (anti-CD69 antibody binding capacity) measurements of CD69 surface expression. Whole-blood samples from 21 healthy and 21 human immunodeficiency virus (HIV)-infected (<500 absolute CD4 counts per mm3) individuals were stimulated with 20 μg of PHA per ml for 18 to 24 h. The proportions of activated CD4 and CD8 T lymphocytes expressing CD69 (percent CD69) and the levels of CD69 expression on each T-lymphocyte subset (anti-CD69 antibody binding capacity) were measured. By using this assay system, T-lymphocyte activation was impaired in both CD4 and CD8 T-lymphocyte subsets of HIV-infected individuals. The proportions of CD69-positive CD4 and CD8 T lymphocytes were 43 and 27% lower, respectively, in samples from HIV-infected individuals compared to samples from healthy individuals. Similarly, the levels of CD69 expression on each activated CD4 and CD8 T-lymphocyte subset were 48 and 51% lower, respectively. These results suggest that both qualitative and semiquantitative measurements of CD69 surface expression by flow cytometry can be used to assess T-lymphocyte activation.
A Whole-Blood Assay for Qualitative and Semiquantitative Measurements of CD69 Surface Expression on CD4 and CD8 T Lymphocytes Using Flow Cytometry
Lony C. L. Lim, Michelle N. Fiordalisi, Janet L. Mantell, John L. Schmitz,* and James D. Folds