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Poriol

$980

Brand : BIOFRON
Catalogue Number : AV-C10072
Specification : 98%
CAS number : 14348-16-4
Formula : C16H14O5
Molecular Weight : 286.28
PUBCHEM ID : 301798
Volume : 5mg

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Catalogue Number

AV-C10072

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

286.28

Appearance

Powder

Botanical Source

Structure Type

Category

Standards;Natural Pytochemical;API

SMILES

CC1=C(C2=C(C=C1O)OC(CC2=O)C3=CC=C(C=C3)O)O

Synonyms

5,7-Dihydroxy-2-(4-hydroxyphenyl)-6-methyl-2,3-dihydro-4H-chromen-4-one/Poriol

IUPAC Name

5,7-dihydroxy-2-(4-hydroxyphenyl)-6-methyl-2,3-dihydrochromen-4-one

Density

1.434g/cm3

Solubility

Flash Point

225.4ºC

Boiling Point

588.6ºC at 760mmHg

Melting Point

InChl

InChI=1S/C16H14O5/c1-8-11(18)6-14-15(16(8)20)12(19)7-13(21-14)9-2-4-10(17)5-3-9/h2-6,13,17-18,20H,7H2,1H3

InChl Key

SLFZBNOERHGNMI-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

2932990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:14348-16-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

21398489

Abstract

Mycobacteria are among the microorganisms least susceptible to biocides but cause devastating diseases, such as tuberculosis, and increasingly opportunistic infections. The exceptional resistance of mycobacteria to toxic solutes is due to an unusual outer membrane, which acts as an efficient permeability barrier, in synergy with other resistance mechanisms. Porins are channel-forming proteins in the outer membrane of mycobacteria. In this study we used the alamarBlue assay to show that the deletion of Msp porins in isogenic mutants increased the resistance of Mycobacterium smegmatis to isothiazolinones (methylchloroisothiazolinone [MCI]/methylisothiazolinone [MI] and octylisothiazolinone [2-n-octyl-4-isothiazolin-3-one; OIT]), formaldehyde-releasing biocides {hexahydrotriazine [1,3,5-tris (2-hydroxyethyl)-hexahydrotriazine; HHT] and methylenbisoxazolidine [N,N′-methylene-bis-5-(methyloxazolidine); MBO]}, and the lipophilic biocides polyhexamethylene biguanide and octenidine dihydrochloride 2- to 16-fold. Furthermore, the susceptibility of the porin triple mutant against a complex disinfectant was decreased 8-fold compared to wild-type (wt) M. smegmatis. Efficacy testing in the quantitative suspension test EN 14348 revealed 100-fold improved survival of the porin mutant in the presence of this biocide. These findings underline the importance of porins for the susceptibility of M. smegmatis to biocides.

Title

Importance of Porins for Biocide Efficacy against Mycobacterium smegmatis

Author

Elrike Frenzel, Stefan Schmidt, Michael Niederweis, Katrin Steinhauer

Publish date

2011 May

PMID

30346053

Abstract

Purpose
Magnetic resonance imaging protocols for the assessment of quantitative information suffer from long acquisition times since multiple measurements in a parametric dimension are required. To facilitate the clinical applicability, accelerating the acquisition is of high importance. To this end, we propose a model?based optimization framework in conjunction with undersampling 3D radial stack?of?stars data.

Theory and Methods
High resolution 3D T 1 maps are generated from subsampled data by employing model?based reconstruction combined with a regularization functional, coupling information from the spatial and parametric dimension, to exploit redundancies in the acquired parameter encodings and across parameter maps. To cope with the resulting non?linear, non?differentiable optimization problem, we propose a solution strategy based on the iteratively regularized Gauss?Newton method. The importance of 3D?spectral regularization is demonstrated by a comparison to 2D?spectral regularized results. The algorithm is validated for the variable flip angle (VFA) and inversion recovery Look?Locker (IRLL) method on numerical simulated data, MRI phantoms, and in vivo data.

Results
Evaluation of the proposed method using numerical simulations and phantom scans shows excellent quantitative agreement and image quality. T 1 maps from accelerated 3D in vivo measurements, e.g. 1.8 s/slice with the VFA method, are in high accordance with fully sampled reference reconstructions.

Conclusions
The proposed algorithm is able to recover T 1 maps with an isotropic resolution of 1 mm3 from highly undersampled radial data by exploiting structural similarities in the imaging volume and across parameter maps.

KEYWORDS

constrained reconstruction, inversion?recovery Look?Locker, imaging, model?based reconstruction, MRI, T1 quantification, variable flip angle

Title

Rapid T1 quantification from high resolution 3D data with model?based reconstruction

Author

Oliver Maier, Jasper Schoormans, Matthias Schloegl, Gustav J. Strijkers, Andreas Lesch, Thomas Benkert, Tobias Block, Bram F. Coolen, Kristian Bredies, Rudolf Stollberger

Publish date

2019 Mar;

PMID

17724343

Abstract

Subcellular compartmentalization has become an important theme in cell signaling such as spatial regulation of Ras by RasGRP1 and MEK/ERK by Sef. Here, we report spatial regulation of Raf kinase by RKTG (Raf kinase trapping to Golgi). RKTG is a seven-transmembrane protein localized at the Golgi apparatus. RKTG expression inhibits EGF-stimulated ERK and RSK phosphorylation, blocks NGF-mediated PC12 cell differentiation, and antagonizes Ras- and Raf-1-stimulated Elk-1 transactivation. Through interaction with Raf-1, RKTG changes the localization of Raf-1 from cytoplasm to the Golgi apparatus, blocks EGF-stimulated Raf-1 membrane translocation, and reduces the interaction of Raf-1 with Ras and MEK1. In RKTG-null mice, the basal ERK phosphorylation level is increased in the brain and liver. In RKTG-deleted mouse embryonic fibroblasts, EGF-induced ERK phosphorylation is enhanced. Collectively, our results reveal a paradigm of spatial regulation of Raf kinase by RKTG via sequestrating Raf-1 to the Golgi apparatus and thereby inhibiting the ERK signaling pathway.

KEYWORDS

EGF, ERK, Golgi, Raf-1, Ras, PAQR3

Title

Spatial regulation of Raf kinase signaling by RKTG

Author

Lin Feng, Xiaoduo Xie, Qiurong Ding, Xiaolin Luo, Jing He, Fengjuan Fan, Weizhong Liu, Zhenzhen Wang, and Yan Chen*

Publish date

2007 Sep 4;