White crystalline powder
Propyl parahydroxybenzoate/Propyl-4-hydroxybenzoate/Mekkings P/4-hydroxybenzoic acid propyl ester/nipaginp/PROPYL PARASEPT/4-10-00-00374/Nipasol M/Benzoic acid, p-hydroxy-, propyl ester/N-Propyl-p-hydroxybenzoate/Propyl chemosept/nipasolp/n-Propyl p-hydroxybenzoate/n-propyl 4-hydroxybenzoate/n-Propylparaben/Paseptol/Nipazol/4-Hydroxybenzoic acid, n-propyl ester/propyl paraben/Solbrol P/p-Hydroxybenzoic acid n-propyl ester/Propagin/4-Hydroxybenzoic acid n-propyl ester/propyl p-hydroxybenzoate/Benzoic acid, 4-hydroxy-, propyl ester/p-Hydroxybenzoic acid, propyl ester/p-hydroxybenzoic acid propyl ester/Nipasol/Parabens/Propylparaben/n-Propyl-4-hydroxy-benzoate/solbrolp/Propyl 4-hydroxybenzoate/NipasolM/betacidep
294.3±13.0 °C at 760 mmHg
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For Reference Standard and R&D, Not for Human Use Directly.
provides coniferyl ferulate(CAS#:94-13-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
The determination of the fluorescence quantum yield of Propylparaben is introduced and applied to L-tyrosine as a standard by a new approach that can be applied to the pharmaceutical compound utilised in this study. The quantum yield is a critical figure of quality for the optical nature of a fluorophore. Numerous investigations have considered the glitter in both pharmaceutical and nature compounds for its medical and industrial significance. A straightforward method is detailed here to decide the quantum yield of Propylparaben in solution as an element of the fluorescence concentration. For this reason, L-Tyrosine is chosen as a fluorescence standard perspective to gauge the Propylparaben fluorescence quantum yield. The impacts of pH, solvents and flow rate on the assessment of quantum yield and quantum efficiency, for the reference and the solutions of Propylparaben, have been investigated. The results indicated that these parameters significantly influence the accuracy of the method. Diverse methods are concentrated on to represent distinctive quantum yield advancements with the quantum efficiency. The impact of these parameters was likewise considered. In this study, the application of the single method may be taken into consideration to compute quantum yield of Propylparaben, which was 0.36, and this is an exceptionally basic and general technique to solve the imperative issue of luminescence quantum yield assurance of other fluorescence compounds.
Excitation and emission measurements; Flow injection; Fluorescence quantum yield; Fluorescence spectroscopy; Luminescence; Quantum efficiency
Fluorescence Quantum Yield Determination of Propylparaben Using Flow Injection Spectroscopy.
Hashim KK1, Yahyaa SY2, Mohmmed Al-Rashidy AA3.
There are conflicting literature reports that parabens, useful antimicrobial additives in pharmaceuticals, may have estrogenic activity. We conducted a comprehensive study to determine whether propylparaben (PP) administration to juvenile rats is associated with adverse effects on reproductive development and function. PP was administered orally once daily to groups of Crl:CD(SD) rats at doses of 0 (vehicle), 10, 100, or 1,000 mg/kg on Postnatal Days (PNDs) 4-90. In-life observations, clinical pathology, reproductive organ weights and histopathology, landmarks of sexual maturation, estrous cyclicity and functional reproductive competence were assessed. A conventional uterotrophic assay was conducted separately using the same doses. Systemic exposures to PP and 3 metabolites were evaluated on PND 7, 21 and 83. These studies demonstrated that PP was well tolerated when administered from PND 4-90 at all doses (AUC[0-T] on PND 83 = 69.9 ng•h/mL). Para-hydroxybenzoic acid, a non-estrogenic compound, was the predominant metabolite contributing to 95% of the total exposure at 1,000 mg/kg/day on PND 7. There was no evidence of estrogenic activity at any dose, and no effects on reproductive organs or function. The No-Observed-Adverse-Effect-Level (NOAEL) was 1,000 mg/kg/day.
Copyright © 2017 Elsevier Inc. All rights reserved.
Estrogen/estrogenic; Fertility assessment; Juvenile rats; Maturation; Pediatric; Propylparaben; Reproduction; Reproductive organs; Sexual maturation; Uterotrophic assay
Safety assessment of propylparaben in juvenile rats.
Sivaraman L1, Pouliot L2, Wang B3, Brodie T3, Graziano M3, McNerney ME3.
Propylparaben is prevalently used in cosmetics, pharmaceuticals, and foods; yet, its direct effects on the mammalian ovary are unknown. We investigated the direct effects of propylparaben on the growth and steroidogenic function of mouse antral follicles. Antral follicles were isolated from the ovaries of Swiss mice (age: 32-42 days) and cultured in media with dimethylsulfoxide vehicle control or propylparaben (0.01-100 μg/mL) for 24-72 h. Follicle diameter was measured every 24 h to assess growth. Follicles and media were collected at 24 and 72 h for gene expression and hormone measurements. Propylparaben (100 μg/mL) significantly inhibited follicle growth (48-72 h). Further, propylparaben exposure increased expression of cell cycle regulators (Cdk4, Cdkn1a), an apoptotic factor (Bax), and a key steroidogenic regulator (Star). In media, propylparaben decreased accumulation of dehydroepiandrosterone-sulfate, but increased testosterone and 17β-estradiol. Overall, our findings suggest that propylparaben disrupts antral follicle growth and steroidogenic function by altering the cell-cycle, apoptosis, and steroidogenesis pathways.
Copyright © 2019 Elsevier Inc. All rights reserved.
Apoptosis; Cell-cycle; Cosmetics; Ovary; Paraben; Steroidogenesis
Propylparaben inhibits mouse cultured antral follicle growth, alters steroidogenesis, and upregulates levels of cell-cycle and apoptosis regulators.
Gal A1, Gedye K2, Craig ZR3, Ziv-Gal A4.
Propylparaben is an antimicrobial agent, preservative, flavouring agent.