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Protoescigenin

$480

  • Brand : BIOFRON

  • Catalogue Number : BN-O1746

  • Specification : 98%(HPLC)

  • CAS number : 20853-07-0

  • Formula : C30H50O6

  • Molecular Weight : 506.7

  • PUBCHEM ID : 15560300

  • Volume : 5mg

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Catalogue Number

BN-O1746

Analysis Method

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

506.7

Appearance

Botanical Source

Structure Type

Category

SMILES

CC1(CC2C3=CCC4C5(CCC(C(C5CCC4(C3(CC(C2(C(C1O)O)CO)O)C)C)(C)CO)O)C)C

Synonyms

Protoaescigenin/protoescigenin/Olean-12-ene-3β,16α,21β,22α,24,28-hexol/Olean-12-ene-3,16,21,22,24,28-hexol, (3β,16α,21β,22α)-/protoescigenine (reference grade)/(3β,16α,21β,22α)-Olean-12-ene-3,16,21,22,24,28-hexol

IUPAC Name

(3R,4R,4aR,5R,6aR,6aS,6bR,8aR,9S,10S,12aR,14bS)-4a,9-bis(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-3,4,5,10-tetrol

Density

1.2±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

262.0±26.1 °C

Boiling Point

634.5±55.0 °C at 760 mmHg

Melting Point

InChl

InChl Key

VKJLHZZPVLQJKG-JAGYOTNFSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:20853-07-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

25745765

Abstract

Escin, a complex mixture of pentacyclic triterpene saponins obtained from horse chestnut seeds extract (HCSE; Aesculus hippocastanum L.), constitutes a traditional herbal active substance of preparations (drugs) used for a treatment of chronic venous insufficiency and capillary blood vessel leakage. A new approach to exploitation of pharmacological potential of this saponin complex has been recently proposed, in which the β-escin mixture is perceived as a source of a hitherto unavailable raw material, pentacyclic triterpene aglycone-protoescigenin. Although many liquid chromatography methods are described in the literature for saponins determination, analysis of protoescigenin is barely mentioned. In this work, a new ultra-high performance liquid chromatography (UHPLC) method developed for protoescigenin quantification has been described. CAD (charged aerosol detection), as a relatively new detection method based on aerosol charging, has been applied in this method as an alternative to ultraviolet (UV) detection. The influence of individual parameters on CAD response and sensitivity was studied. The detection was performed using CAD and UV (200 nm) simultaneously and the results were compared with reference to linearity, accuracy, precision and limit of detection.

Title

Comparison of ultraviolet detection and charged aerosol detection methods for liquid-chromatographic determination of protoescigenin.

Author

Filip K, Grynkiewicz G, Gruza M, Jatczak K, Zagrodzki B.

Publish date

2014 Nov-Dec

PMID

23591921

Abstract

A two-step chemical process for controlled degradation of escin, affording a mixture of olean-12-ene sapogenins, was elaborated and scaled up. The main component of the mixture–protoescigenin–was isolated and purified, in the form of its corresponding monohydrate, without resource to chromatographic methods. This material was further converted into the high purity 3,24;16,22-di-O,O-isopropylidene derivative in a validated large scale laboratory process.

Title

Preparation, purification and regioselective functionalization of protoescigenin--the main aglycone of escin complex.

Author

Gruza MM1, Jatczak K, Zagrodzki B, Laszcz M, Koziak K, Malińska M, Cmoch P, Giller T, Zegrocka-Stendel O, Woźniak K, Grynkiewicz G.


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