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Pseudotropine

$64

Brand : BIOFRON
Catalogue Number : BN-O0043
Specification : 98%(HPLC)
CAS number : 135-97-7
Formula : C8H15NO
Molecular Weight : 141.21
PUBCHEM ID : 8424
Volume : 20mg

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Catalogue Number

BN-O0043

Analysis Method

Specification

98%(HPLC)

Storage

-20℃

Molecular Weight

141.21

Appearance

Oil

Botanical Source

This product is isolated and purified from the roots of Atropa belladonna

Structure Type

Category

SMILES

CN1C2CCC1CC(C2)O

Synonyms

8-Methyl-8-azabicyclo[3.2.1]octan-3-ol/3-Pseudotropanol/8-Azabicyclo[3.2.1]octan-3-ol, 8-methyl-/Pseudotropine/3-exo-8-Methyl-8-azabicyclo[3.2.1]octan-3-ol

IUPAC Name

Density

1.1±0.1 g/cm3

Solubility

Flash Point

112.5±14.5 °C

Boiling Point

233.0±0.0 °C at 760 mmHg

Melting Point

InChl

InChl Key

CYHOMWAPJJPNMW-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:135-97-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

31406117

Abstract

Tropane alkaloids (TAs) are a class of phytochemicals produced by plants of the nightshade family used for treating diverse neurological disorders. Here, we demonstrate de novo production of tropine, a key intermediate in the biosynthetic pathway of medicinal TAs such as scopolamine, from simple carbon and nitrogen sources in yeast (Saccharomyces cerevisiae). Our engineered strain incorporates 15 additional genes, including 11 derived from diverse plants and bacteria, and 7 disruptions to yeast regulatory or biosynthetic proteins to produce tropine at titers of 6 mg/L. We also demonstrate the utility of our engineered yeast platform for the discovery of TA derivatives by combining biosynthetic modules from distant plant lineages to achieve de novo production of cinnamoyltropine, a non-canonical TA. Our engineered strain constitutes a starting point for future optimization efforts towards realizing industrial fermentation of medicinal TAs and a platform for the synthesis of TA derivatives with enhanced bioactivities.

Title

Engineering a microbial biosynthesis platform for de novo production of tropane alkaloids.

Author

Srinivasan P1, Smolke CD2,3.

Publish date

2019 Aug 12

PMID

30857698

Abstract

In this study, the degradation of tropane alkaloids in pasta under boiling (100 °C during 10 min) and tea making (100 °C and let cool 5 min) conditions has been evaluated for the first time. Pasta and green tea were contaminated with Datura Stramonium and Brugmansia Arborea seeds (pasta and green tea), whereas coca leaf tea was directly analysed. The compounds were extracted using solid-liquid extraction coupled to a preconcentration stage (only for the cooking water), and the compounds were analysed by liquid chromatography coupled to mass spectrometry (Exactive-Orbitrap analyser). Degradation studies indicate that concentration of tropane alkaloids decreases, and it depends on the compound, observing the highest degradation for tropinone, tropane, cuscohygrine and tropine, as well as it was observed that compounds migrated to the aqueous phase during cooking step. Finally, post-targeted analysis was performed and other tropane alkaloids were found, as scopine, tigloidine or convolvine, showing a similar behaviour under cooking conditions.

Copyright © 2019 Elsevier Ltd. All rights reserved.

KEYWORDS

Buckwheat; Degradation study; Post-targeted analysis; Processed samples; Tea; Tropane alkaloids

Title

Effect of tea making and boiling processes on the degradation of tropane alkaloids in tea and pasta samples contaminated with Solanaceae seeds and coca leaf.

Author

Marin-Saez J1, Romero-Gonzalez R1, Garrido Frenich A2.

Publish date

2019 Jul 30

PMID

30429086

Abstract

Emulsion liquid membrane (ELM) coupled with tropine-based ionic liquid was prepared and successfully adopted for the extraction and quantitative analysis of tropane alkaloids (TA) in Radix physochlainae. Effects of formation conditions of ELM were explored and then optimized; the ideal oil-water mass ratio was determined to be 1:2.5, chloroform, Span 80 and 0.05 mol L-1N-propyl-tropine hexafluorophosphate ([C3Tr][PF6]) aqueous solution were stirred for 30 min with the speed of 1500 r min-1. In order to extract and enrich TA with ELM efficiently, key factors related with their extraction efficiency such as stirring speed, volume of the extracts (feed solution), migration time and initial concentration of TA were systematically investigated. Under optimal conditions, 1.5 mL extracts containing 1.6 mg mL-1 of TA was stirred with ELM at 250 r min-1 for 5 min, the extraction efficiency of target alkaloid can reach 94.14%. Finally, the method could be used in quantitative analysis of TA in herbal material and patent medicine after demulsification. By comparison, application of ELM for the enrichment and quantitation of TA offers a more straightforward and effective strategy, which is expected to provide a meaningful reference for similar separation processes.

Copyright © 2018 Elsevier B.V. All rights reserved.

KEYWORDS

Emulsion liquid membrane; Extraction; Tropane alkaloids; Tropine ionic liquid

Title

Extraction and quantitative analysis of tropane alkaloids in Radix physochlainae by emulsion liquid membrane with tropine-based ionic liquid.

Author

Tang J1, Liang S1, Dong B1, Li Y1, Yao S2.

Publish date

2019 Jan 4.