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Pterosin A

$576

  • Brand : BIOFRON

  • Catalogue Number : BN-O1331

  • Specification : 94%(HPLC)

  • CAS number : 35910-16-8

  • Formula : C15H20O3

  • Molecular Weight : 248.32

  • PUBCHEM ID : 135017

  • Volume : 5mg

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Catalogue Number

BN-O1331

Analysis Method

Specification

94%(HPLC)

Storage

2-8°C

Molecular Weight

248.32

Appearance

Botanical Source

Structure Type

Category

SMILES

CC1=CC2=C(C(=C1CCO)C)C(=O)C(C2)(C)CO

Synonyms

(S)-6-(2-Hydroxy-ethyl)-2-hydroxymethyl-2,5,7-trimethyl-indan-1-one/(2S)-Pterosin-A/(2S)-Pterosin A/Pterosin A/pterosin A

IUPAC Name

(2S)-6-(2-hydroxyethyl)-2-(hydroxymethyl)-2,5,7-trimethyl-3H-inden-1-one

Density

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

Boiling Point

Melting Point

InChl

InChl Key

BDZJLPDYMKPKGC-HNNXBMFYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:35910-16-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

23069626

Abstract

The therapeutic effect of pterosin A, a small-molecular-weight natural product, on diabetes was investigated. Pterosin A, administered orally for 4 weeks, effectively improved hyperglycemia and glucose intolerance in streptozotocin, high-fat diet-fed, and db/db diabetic mice. There were no adverse effects in normal or diabetic mice treated with pterosin A for 4 weeks. Pterosin Asignificantly reversed the increased serum insulin and insulin resistance (IR) in dexamethasone-IR mice and in db/db mice. Pterosin A significantly reversed the reduced muscle GLUT-4 translocation and the increased liver phosphoenolpyruvate carboxyl kinase (PEPCK) expression in diabetic mice. Pterosin A also significantly reversed the decreased phosphorylations of AMP-activated protein kinase (AMPK) and Akt in muscles of diabetic mice. The decreased AMPK phosphorylation and increased p38 phosphorylation in livers of db/db mice were effectively reversed by pterosin A. Pterosin A enhanced glucose uptake and AMPK phosphorylation in cultured human muscle cells. In cultured liver cells, pterosin A inhibited inducer-enhanced PEPCK expression, triggered the phosphorylations of AMPK, acetyl CoA carboxylase, and glycogen synthase kinase-3, decreased glycogen synthase phosphorylation, and increased the intracellular glycogen level. These findings indicate that pterosin A may be a potential therapeutic option for diabetes.

Title

Antidiabetic effects of pterosin A, a small-molecular-weight natural product, on diabetic mouse models.

Author

Hsu FL1, Huang CF, Chen YW, Yen YP, Wu CT, Uang BJ, Yang RS, Liu SH.

Publish date

2013 Feb


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