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Quercetin

$43

  • Brand : BIOFRON

  • Catalogue Number : BF-Q1001

  • Specification : 98%

  • CAS number : 117-39-5

  • Formula : C15H10O7

  • Molecular Weight : 302.24

  • PUBCHEM ID : 5280343

  • Volume : 20mg

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Catalogue Number

BF-Q1001

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

302.24

Appearance

Yellow crystalline powder

Botanical Source

Albizia julibrissin,Prunella vulgaris,Myrica rubra,Uncaria rhynchophylla,Artemisia annua

Structure Type

Flavonoids

Category

Standards;Natural Pytochemical;API

SMILES

C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O

Synonyms

MELETIN/2',3,4',5,7-pentahydroxyflavone/QUERTINE/2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one/Sophretin/QUERCETOL/QUERCETINE/SOPHORETIN/3,3',4',5,7-Pentahydroxyflavone/Quercetin/QUERCITIN/kvercetin/3,3',4',5,7-pentahydroxylflavone

IUPAC Name

2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one

Density

1.8±0.1 g/cm3

Solubility

Methanol; DMSO; DMF

Flash Point

248.1±25.0 °C

Boiling Point

642.4±55.0 °C at 760 mmHg

Melting Point

314-317°C

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2932990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:117-39-5) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

30103275

Abstract

Quercetin (3,3′,4′,5,7-pentahydroxyflavone) is found in vegetables and fruits. It is one of the major flavonoids that is part of human diets. Quercetin has several pharmacological effects in the nervous system as a neuroprotective agent. In this review, we summarize the research on quercetin and its role in memory in both animals and humans. Articles were chosen from the Scopus, PubMed, and Web of Science databases. In this review, we describe and summarize the importance of quercetin’s presence in the body, particularly in the brain; its kinetics, including its absorption, metabolism, distribution, and excretion; its behavioral effects; and some of the possible mechanisms of action of quercetin on memory in different animal models. Several important pathways that may be involved in the processes of learning and memory, long-term potentiation, and cognition may be impaired during neurological diseases or other medical conditions. As dietary quercetin is important, provision of its best formulation for delivery to the brain as a nutraceutical and in clinical translational research for the prevention or treatment of Alzheimer’s disease and other types of dementia is necessary.

KEYWORDS

Alzheimer's disease; flavonoids; food; memory; quercetin.

Title

Quercetin in Food: Possible Mechanisms of Its Effect on Memory

Author

Fatemeh Babaei 1 , Mohammadreza Mirzababaei 2 , Marjan Nassiri-Asl 3

Publish date

2018 Sep

PMID

31284873

Abstract

The spread of metastatic cancer cell is the main cause of death worldwide. Cellular and molecular basis of the action of phytochemicals in the modulation of metastatic cancer highlights the importance of fruits and vegetables. Quercetin is a natural bioflavonoid present in fruits, vegetables, seeds, berries, and tea. The cancer-preventive activity of quercetin is well documented due to its anti-inflammatory, anti-proliferative and anti-angiogenic activities. However, poor water solubility and delivery, chemical instability, short half-life, and low-bioavailability of quercetin limit its clinical application in cancer chemoprevention. A better understanding of the molecular mechanism of controlled and regulated drug delivery is essential for the development of novel and effective therapies. To overcome the limitations of accessibility by quercetin, it can be delivered as nanoconjugated quercetin. Nanoconjugated quercetin has attracted much attention due to its controlled drug release, long retention in tumor, enhanced anticancer potential, and promising clinical application. The pharmacological effect of quercetin conjugated nanoparticles typically depends on drug carriers used such as liposomes, silver nanoparticles, silica nanoparticles, PLGA (Poly lactic-co-glycolic acid), PLA (poly(D,L-lactic acid)) nanoparticles, polymeric micelles, chitosan nanoparticles, etc. In this review, we described various delivery systems of nanoconjugated quercetin like liposomes, silver nanoparticles, PLGA (Poly lactic-co-glycolic acid), and polymeric micelles including DOX conjugated micelles, metal conjugated micelles, nucleic acid conjugated micelles, and antibody-conjugated micelles on in vitro and in vivo tumor models; as well as validated their potential as promising onco-therapeutic agents in light of recent updates.

KEYWORDS

Drug delivery; PLGA; bioavailability; cancer therapy; nanoparticles; quercetin..

Title

Quercetin Loaded Nanoparticles in Targeting Cancer: Recent Development

Author

Manjula Vinayak 1 , Akhilendra K Maurya 1 2

Publish date

2019

PMID

27633685

Abstract

The dramatic increase in modern lifestyle diseases such as cancer, cardiovascular diseases and diabetes has renewed researchers’ interest to explore nature as a source of novel therapeutic agents. Flavonoids are a large group of polyphenols that are widely present in the human diet. They have shown promising therapeutic activities against a wide variety of ailments. One of the most widely distributed and most extensively studied flavonoid is the flavonol quercetin. Its powerful antioxidant and anti-inflammatory activities are well documented and are thought to play a role in treating and protecting against diseases including diabetes, cancer, neurodegenerative and cardiovascular diseases. The purpose of this review is to shed light on quercetin therapeutic potential as an antidiabetic agent. Quercetin was reported to interact with many molecular targets in small intestine, pancreas, skeletal muscle, adipose tissue and liver to control whole-body glucose homeostasis. Mechanisms of action of quercetin are pleiotropic and involve the inhibition of intestinal glucose absorption, insulin secretory and insulin-sensitizing activities as well as improved glucose utilization in peripheral tissues. Initial studies suggested poor bioavailability of quercetin. However, recent reports have shown that quercetin was detected in the plasma after food or supplements consumption and has a long half-life in human body. Despite the wealth of in vitro and in vivo results supporting the antidiabetic potential of quercetin, its efficacy in diabetic human subjects is yet to be explored.

KEYWORDS

: Flavonoids; glucolipotoxicity; gluconeogenesis; glucose absorption; glucose uptake; insulin resistance; insulin secretion. AMPK.

Title

The Antidiabetic Potential of Quercetin: Underlying Mechanisms

Author

Hoda M Eid 1 , Pierre S Haddad 2

Publish date

2017


Description :

Quercetin is a natural flavonoid which activates or inhibits the activities of a number of proteins. Quercetin can activate SIRT1 and inhibit PI3K with IC50s of 2.4 μM, 3.0 μM, 5.4 μM for PI3K γ, PI3K δ and PI3K β, respecti