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Quinine

$52

  • Brand : BIOFRON

  • Catalogue Number : BD-P0286

  • Specification : 98.0%(HPLC)

  • CAS number : 130-95-0

  • PUBCHEM ID : 3034034

  • Volume : 100mg

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Catalogue Number

BD-P0286

Analysis Method

HPLC,NMR,MS

Specification

98.0%(HPLC)

Storage

2-8°C

Molecular Weight

Appearance

White crystalline powder

Botanical Source

Cinchona ledgeriana (Howard) Moens ex Trim

Structure Type

Quinolines/Isoquinolines

Category

Standards;Natural Pytochemical;API

SMILES

COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O

Synonyms

(R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]oct-2-yl](6-methoxy-4-quinoleinyl)methanol/(-)-Quinine/6'-Methoxycinchonidine/Kinin/cinchonan-9-ol, 6'-methoxy-, (8a,9R)-/Kinidin-d3/Quinina/(R)-(6-Methoxyquinolin-4-yl)((1R,2R,4R,5S)-5-vinylquinuclidin-2-yl)methanol/chinine/Cinchonan-9-ol, 6'-methoxy-, (8α,9R)-/(R)-(6-Methoxy-4-chinolinyl)[(2S,4S,5R)-5-vinyl-1-azabicyclo[2.2.2]oct-2-yl]methanol/(R)-(6-Methoxy-4-quinolinyl)[(2S,4S,5R)-5-vinyl-1-azabicyclo[2.2.2]oct-2-yl]methanol/Chinin/(8S,9R)-6'-Methoxycinchonan-9-ol/(R)-(-)-Quinine/(8a,9R)-6'-methoxycinchonan-9-ol/Cinchonan-9-ol, 6'-methoxy-, (8alpha,9R)-/QUININE/Pitayin-d3/(8α,9R)-6'-Methoxycinchonan-9-ol/Quinie

IUPAC Name

(R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol

Applications

Quinine is an anti-malaria agent and also a potassium channel inhibitor with an IC50 of 169 μM.

Density

1.2±0.1 g/cm3

Solubility

Methanol; Chloroform; Ethyl Acetate; DMSO

Flash Point

253.7±27.3 °C

Boiling Point

495.9±40.0 °C at 760 mmHg

Melting Point

176-177ºC

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2939200000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:130-95-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

27185766

Abstract

Quinine, a bitter-tasting, short-acting alkaloid drug extracted from cinchona bark, was the first drug used widely for malaria chemoprophylaxis from the 19th century. Compliance was difficult to enforce even in organized groups such as the military, and its prophylaxis potential was often questioned. Severe adverse events such as blackwater fever occurred rarely, but its relationship to quinine remains uncertain. Quinine prophylaxis was often counterproductive from a public health viewpoint as it left large numbers of persons with suppressed infections producing gametocytes infective for mosquitoes. Quinine was supplied by the first global pharmaceutical cartel which discouraged competition resulting in a near monopoly of cinchona plantations on the island of Java which were closed to Allied use when the Japanese Imperial Army captured Indonesia in 1942. The problems with quinine as a chemoprophylactic drug illustrate the difficulties with medications used for prevention and the acute need for improved compounds.

Title

Historical Review: Problematic Malaria Prophylaxis With Quinine

Author

G Dennis Shanks 1

Publish date

2016 Aug 3

PMID

25831406

Abstract

The objective of this study was to perform a synthesis and analysis of the most important information on quinine and its derivatives, which are still very important in the treatment of malaria. The analysis of stereoisomers of quinine and its derivatives was conducted using two techniques, high-performance liquid chromatography and capillary electrophoresis. Particularly noteworthy is the technique used for the determination of isotachophoresis, referred to as one of the so-called green chemistry techniques. Particular attention was paid to properties and the use of quinine and its derivatives in the treatment of malaria. The analytical part will supplement knowledge about quinidine, quinine, and cinchonidine, and will contribute to the growth of research on the so-much-needed drugs against malaria.

KEYWORDS

Cinquinidine; HPLC; isotachophoresis; malaria; quinidine; quinine.

Title

Analytics of Quinine and Its Derivatives

Author

Mariusz Kluska 1 , Anna Marciniuk-Kluska 2 , Dorota Prukała 3 , Wiesław Prukała 3

Publish date

2016

PMID

28665790

Abstract

Background Quinine (QT) is an important anti-malarial drug; however, there is little information about its effects on the gut. Therefore, this study aimed to investigate the effects of a therapeutic dose of QT on the healing of gastric ulcer in rats. Methods Male Wistar rats weighing 150-200 g were divided into three groups: control rats without ulcer (group 1), ulcerated rats treated with 1 mL/kg (p.o.) normal saline (NS) (group 2), and ulcerated rats treated with 10 mg/kg (p.o.) QT (group 3). Ulcers were induced by serosal application of 80 % acetic acid to the stomach of rats anaesthetized with 50 mg/kg thiopentone sodium and treatment was given three times daily. Healing was assessed on days 3, 7 and 10 after ulcer induction by macroscopic measurement of: ulcer area, histology, lipid peroxidation, superoxide dismutase activity and gastric mucus secretion. Results At day 3, there was no significant difference (p>0.05) in ulcer areas between NS- and QT-treated rats. By day 10, however, the percentage area healed in NS treated (59.6±2.35 %) was significantly higher (p<0.05) than in QT rats (49.0±2.20 %) and clearing of inflammatory cells and re-epithelization was greater in NS-treated group. By days 7 and 10, lipid peroxidation was significantly higher in QT animals, when compared with NS-treated rats and controls (p<0.05). Superoxide dismutase activity and mucus secretion were significantly (p<0.05) higher in NS-treated than QT-treated rats. Conclusions QT delayed ulcer healing by prolonging the inflammatory phase of healing, increasing oxidative stress, reducing antioxidant activity and gastric mucus secretion.

KEYWORDS

antioxidant; gastric ulcer; healing; mucus; quinine.

Title

Effects of Quinine on Gastric Ulcer Healing in Wistar Rats

Author

Olasupo Stephen Adeniyi 1 , Olubiyi Vincent Makinde 1 , Emmanuel Titus Friday 1 , Samuel Babafemi Olaleye 1

Publish date

2017 Jun 29