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Retinoic acid

$64

Brand : BIOFRON
Catalogue Number : BN-O0044
Specification : 98%(HPLC)
CAS number : 302-79-4
Formula : C20H28O2
Molecular Weight : 300.44
PUBCHEM ID : 444795
Volume : 20mg

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Catalogue Number

BN-O0044

Analysis Method

HPLC,NMR,MS

Specification

98%(HPLC)

Storage

-20℃

Molecular Weight

300.44

Appearance

Yellow powder

Botanical Source

This product is isolated and purified from the lamb liver

Structure Type

Category

Standards;Natural Pytochemical;API

SMILES

CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C

Synonyms

(2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid/eudyna/Tretinoin, all-trans-/effederm/all-trans-β-Retinoic acid/aknoten/β-Retinoic acid/all trans-Retinoic acid/Atragen/all-trans tretinoin/15-Apo-b-caroten-15-oic acid/(all-e)/trans-Retinoic acid/Tretinoin/all-trans retinoic acid/trans-Vitamin a acid/all-trans-Tretinoin/13-cis-retinoic acid/all-trans-vitamin A acid/retin-a/ALL-TRANS-RETINOIC ACID/aberel/all-trans-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic Acid/β-all-trans-Retinoic acid/Retinoic acid, all-trans-/Vitamin A Acid/Acid A Vit/[3H]-Retinoic Acid/tretinm/ATRA/Retinoic acid

IUPAC Name

(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid

Density

1.0±0.1 g/cm3

Solubility

Flash Point

350.6±11.0 °C

Boiling Point

462.8±14.0 °C at 760 mmHg

Melting Point

179-184ºC

InChl

InChl Key

SHGAZHPCJJPHSC-YCNIQYBTSA-N

WGK Germany

RID/ADR

HS Code Reference

2936210000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:302-79-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

32212524

Title

Case 10-2020: An 83-Year-Old Man with Pancytopenia and Acute Renal Failure.

Author

Sykes DB1, Zhang EW1, Karp Leaf RS1, Nardi V1, Turbett SE1.

Publish date

2020 Mar 26;

PMID

32147608

Abstract

A 69-year-old woman with leukocytopenia and thrombocytopenia was referred to our hospital. Her bone marrow comprised 70.5% abnormal promyelocytes that were positive for myeloperoxidase/CD33/CD117 and CD13 (dim) and negative for CD2/CD34/CD56 and HLA-DR. Chromosome analysis of the bone marrow showed t (12;17;15) (p13;q21;q22), and fluorescence in situ hybridization revealed the PML-RARA fusion signal only on the derivative chromosome 15. The patient was diagnosed with acute promyelocytic leukemia (APL) with PML-RARA and was treated using all-trans retinoic acid (ATRA). In peripheral blood (PB), PML-RARA-positive polymorphonuclear cells (PMNs) appeared on the second week and became negative on the sixth week after treatment, whereas PML-RARA-negative PMNs started to increase in number on the sixth week. Molecular remission was confirmed on the 10th week. Quantitative evaluation of the differentiated leukemic cells of APL and recovered cells from normal hematopoiesis in PB can provide useful information for a safer induction therapy. No significant difference was noted in the kinetics of the leukemic cells under ATRA treatment as well as in the clinical features between our patient without RARA-PML and those with t (15;17), which is a cytogenetic evidence for the critical role of PML-RARA in the pathogenesis of APL.

KEYWORDS

All-trans retinoic acid; Fluorescence in situ hybridization; Variant translocation

Title

[Leukemic cell kinetics of APL with a novel complex variant t (12;17;15)(p13;q21;q22)].

Author

Saiki Y1, Sakai H1, Uchida A1, Uemura Y1, Matsunawa M1, Isobe Y1, Kato M1, Tomita N1, Miura I2, Arai A1.

Publish date

2020

PMID

32054698

Abstract

Sex determination of germ cells is vital to creating the sexual dichotomy of germ cell development, thereby ensuring sexual reproduction. However, the underlying mechanisms remain unclear. Here, we show that ZGLP1, a conserved transcriptional regulator with GATA-like zinc fingers, determines the oogenic fate in mice. ZGLP1 acts downstream of bone morphogenetic protein, but not retinoic acid (RA), and is essential for the oogenic program and meiotic entry. ZGLP1 overexpression induces differentiation of in vitro primordial germ cell-like cells (PGCLCs) into fetal oocytes by activating the oogenic programs repressed by Polycomb activities, whereas RA signaling contributes to oogenic program maturation and PGC program repression. Our findings elucidate the mechanism for mammalian oogenic fate determination, providing a foundation for promoting in vitro gametogenesis and reproductive medicine.

Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Title

ZGLP1 is a determinant for the oogenic fate in mice.

Author

Nagaoka SI1,2, Nakaki F2, Miyauchi H2, Nosaka Y1,2, Ohta H1,2, Yabuta Y1,2, Kurimoto K2, Hayashi K2, Nakamura T1,2, Yamamoto T1,3,4,5, Saitou M6,2,3.

Publish date

2020 Mar 6;3