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(+)-Rhododendrol

$1,000 $900

  • Brand : BIOFRON

  • Catalogue Number : BN-O1724

  • Specification : 98%(HPLC)

  • CAS number : 59092-94-3

  • Formula : C10H14O2

  • Molecular Weight : 166.22

  • PUBCHEM ID : 919204

  • Volume : 5MG

In stock

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Catalogue Number

BN-O1724

Analysis Method

HPLC,NMR,MS

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

166.22

Appearance

Powder

Botanical Source

Structure Type

Phenols

Category

Standards;Natural Pytochemical;API

SMILES

CC(CCC1=CC=C(C=C1)O)O

Synonyms

4-[(3S)-3-Hydroxybutyl]phenol/(+)-Rhododendrol/Benzenepropanol, 4-hydroxy-α-methyl-, (αS)-

IUPAC Name

4-[(3S)-3-hydroxybutyl]phenol

Applications

Density

1.1±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

153.4±15.5 °C

Boiling Point

315.4±17.0 °C at 760 mmHg

Melting Point

78-78.5℃ (chloroform )

InChl

InChI=1S/C10H14O2/c1-8(11)2-3-9-4-6-10(12)7-5-9/h4-8,11-12H,2-3H2,1H3/t8-/m0/s1

InChl Key

SFUCGABQOMYVJW-QMMMGPOBSA-N

WGK Germany

RID/ADR

HS Code Reference

2933990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:59092-94-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

24890809

Abstract

Rhododendrol, an inhibitor of melanin synthesis developed for lightening/whitening cosmetics, was recently reported to induce a depigmentary disorder principally at the sites of repeated chemical contact. Rhododendrol competitively inhibited mushroom tyrosinase and served as a good substrate, while it also showed cytotoxicity against cultured human melanocytes at high concentrations sufficient for inhibiting tyrosinase. The cytotoxicity was abolished by phenylthiourea, a chelator of the copper ions at the active site, and by specific knockdown of tyrosinase with siRNA. Hence, the cytotoxicity appeared to be triggered by the enzymatic conversion of rhododendrol to active product(s). No reactive oxygen species were detected in the treated melanocytes, but up-regulation of the CCAAT-enhancer-binding protein homologous protein gene responsible for apoptosis and/or autophagy and caspase-3 activation were found to be tyrosinase dependent. These results suggest that a tyrosinase-dependent accumulation of ER stress and/or activation of the apoptotic pathway may contribute to the melanocyte cytotoxicity.

© 2014 The Authors. Pigment Cell & Melanoma Research Published by John Wiley & Sons Ltd.

KEYWORDS

ER stress; chemical leukoderma; cytotoxicity; depigmentation; rhododendrol; tyrosinase; vitiligo

Title

Rhododendrol, a depigmentation-inducing phenolic compound, exerts melanocyte cytotoxicity via a tyrosinase-dependent mechanism.

Author

Sasaki M1, Kondo M, Sato K, Umeda M, Kawabata K, Takahashi Y, Suzuki T, Matsunaga K, Inoue S.

Publish date

2014 Sep