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Rhodojaponin III

$420

  • Brand : BIOFRON

  • Catalogue Number : BD-P0017

  • Specification : 98.0%(HPLC)

  • CAS number : 26342-66-5

  • PUBCHEM ID : 21151017

  • Volume : 20mg

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Catalogue Number

BD-P0017

Analysis Method

HPLC,NMR,MS

Specification

98.0%(HPLC)

Storage

2-8°C

Molecular Weight

Appearance

White crystalline powder

Botanical Source

Rhododendron molle G. Don/Rhododendron japonicum and Rhododendron molle

Structure Type

Diterpenoids

Category

Standards;Natural Pytochemical;API

SMILES

CC1(C2C(O2)C3C1(C(CC45CC(C(C4O)CCC5C3(C)O)(C)O)O)O)C

Synonyms

Rhodoislandin B/Rhodojaponin-III/Grayanotoxane-5,6,10,14,16-pentol, 2,3-epoxy-, (2β,3β,6β,14S)-/(2β,3β,6β,14R)-2,3-epoxygrayanotoxane-5,6,10,14,16-pentol/Rhodojaponin III/(2β,3β,6β,14S)-2,3-Epoxygrayanotoxane-5,6,10,14,16-pentol

IUPAC Name

(1S,3R,4R,6R,8S,9S,10R,11R,14R,15R,17R)-5,5,10,15-tetramethyl-7-oxapentacyclo[12.2.1.01,11.04,9.06,8]heptadecane-3,4,10,15,17-pentol

Density

1.4±0.1 g/cm3

Solubility

Methanol; Chloroform; Ethyl Acetate

Flash Point

290.9±30.1 °C

Boiling Point

557.3±50.0 °C at 760 mmHg

Melting Point

InChl

InChI=1S/C20H32O6/c1-16(2)15-12(26-15)13-18(4,24)10-6-5-9-14(22)19(10,8-17(9,3)23)7-11(21)20(13,16)25/h9-15,21-25H,5-8H2,1-4H3/t9?,10-,11+,12-,13-,14-,15-,17+,18+,19-,20+/m0/s1

InChl Key

VUMZHZYKXUYIHM-LISCSQOCSA-N

WGK Germany

RID/ADR

HS Code Reference

2938900000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:26342-66-5) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

31301694

Abstract

Rhodojaponin III is a bioactive diterpenoid isolated from the medicinal plant Rhododendron molle G. Don. Quantitative analysis of rhodojaponin III was challenging and the pharmacokinetics of oral rhodojaponin III remained to be investigated. Here, a rapid and sensitive liquid chromatography tandem mass spectrometric (LC-MS/MS) method was developed and validated. The calibration curve was linear over the concentration range of 1-200 ng/mL (r = 0.992). The method was further validated following internationally approved guidelines and all the issues including intra- and inter-day precision, accuracy, carryover, extraction recovery, matrix effects and stability met the recommended limits. The method was then applied to study the pharmacokinetics of rhodojaponin III in mice after intravenous (0.06 mg/kg) or oral (0.24 mg/kg) administration. The results showed that rhodojaponin III had fast oral absorption (time to peak concentration, 0.08 h) and good oral bioavailability (73.6%). In addition, rhodojaponin III was quickly eliminated after it was intravenously or orally administered, with half-life values of 0.19 and 0.76 h, respectively. After oral administration, it was widely distributed in tissues including kidney, lung, heart, spleen and thymus, but had extremely low concentrations in liver and brain. The data presented in this study is beneficial for the further study of rhodojaponin III.

KEYWORDS

LC-MS/MS; bioavailability; pharmacokinetics; rhodojaponin III; tissue distribution.

Title

Pharmacokinetics, Bioavailability and Tissue Distribution Studies of Rhodojaponin III in Mice Using QTRAP LC-MS/MS

Author

Ji-Quan Zhang 1 , Chun-Cao Zhao 1 , Qing-Yun Yang 1 , Shuang Liang 1 , Fei Wu 1 , Bing-Liang Ma 2 , Yi Feng 1

Publish date

2019 Nov

PMID

24782249

Abstract

In Lepidoptera, choosing the right site for egg laying is particularly important, because the small larvae cannot forage for alternate host plants easily. Some secondary compounds of plants have the ability to deter oviposition behaviors of insects. Rhodojaponin-III, a botanical compound, has been reported to have intense deterring-oviposition activity against many insects, which have important implications for agricultural pest management. This study provided evidence for elucidating the perception mechanism underlying Rhodojaponin-III as oviposition deterrent. In this study, the antennas of moths could not elicit notable electroantennogram responses to Rhodojaponin-III, which suggested the Rhodojaponin-III could not exert effects like those volatile compounds. The results of physiological experiments confirmed the Rhodojaponin-III could produce the oviposition deterrence effect against moths without depending on antennas, while the physical contact was essential for perceiving the compound, which suggested that the sensilla on tarsus and ovipositor could be chemoreceptor for Rhodojaponin-III. Therefore, these sensilla were investigated by scanning electron microscopy to explore their potential functions in detecting Rhodojaponin-III. This study highlighted the contacting mechanism in deterring oviposition behaviors of moths by Rhodojaponin-III and provided new insight for development of contact-based pest management.

KEYWORDS

LC-MS/MS; bioavailability; pharmacokinetics; rhodojaponin III; tissue distribution.

Title

Contacting Is Essential for Oviposition Deterrence of Rhodojaponin-III in Spodoptera Litura

Author

Xin Yi 1 , Jinxiang Liu, Peidan Wang, Meiying Hu, Guohua Zhong

Publish date

2014 Jun

PMID

24155937

Abstract

Rhodojaponin-III is a nonvolatile botanical grayanoid diterpene compound, which has antifeedant and oviposition deterrence effects against many kinds of insects. However, the molecular mechanism of the chemoreception process remains unknown. In this study, the important role of BdorCSP2 in the recognition of Rhodojaponin-III was identified. The full length cDNA encoding BdorCSP2 was cloned from legs of Bactrocera dorsalis. The results of expression pattern revealed that BdorCSP2 was abundantly expressed in the legs of adult B. dorsalis. Moreover, the expression of BdorCSP2 could be up-regulated by Rhodojaponin-III. In order to gain comprehensive understanding of the recognition process, the binding affinity between BdorCSP2 and Rhodojaponin-III was measured by fluorescence binding assay. Silencing the expression of BdorCSP2 through the ingestion of dsRNA could weaken the effect of oviposition deterrence and antifeedant of Rhodojaponin-III. These results suggested that BdorCSP2 of B. dorsalis could be involved in chemoreception of Rhodojaponin-III and played a critical role in antifeedant and oviposition behaviors induced by Rhodojaponin-III.

Title

BdorCSP2 Is Important for Antifeed and Oviposition-Deterring Activities Induced by Rhodojaponin-III Against Bactrocera Dorsalis

Author

Xin Yi 1 , Haiming Zhao, Xiaolin Dong, Peidan Wang, Meiying Hu, Guohua Zhong

Publish date

2013 Oct 14


Description :

Rhodojaponin III is a diterpenoid from the leaves of Rhododendron molle with anti-inflammatory activity[1].