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Rosmarinic acid

$43

  • Brand : BIOFRON

  • Catalogue Number : BF-R1005

  • Specification : 98%

  • CAS number : 20283-92-5

  • Formula : C18H16O8

  • Molecular Weight : 360.31

  • PUBCHEM ID : 5281792

  • Volume : 20mg

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Catalogue Number

BF-R1005

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

360.31

Appearance

White powder

Botanical Source

Perilla frutescens,Salvia miltiorrhiza,Sarcandra glabra,Centella asiatica,Chloranthus multistachys

Structure Type

Phenylpropanoids

Category

Standards;Natural Pytochemical;API

SMILES

C1=CC(=C(C=C1CC(C(=O)O)OC(=O)C=CC2=CC(=C(C=C2)O)O)O)O

Synonyms

R-(+)-2-(3,4-Dihydroxycinnamoyloxy)-3-(3,4-dihydroxyphenyl)propionic acid/ROSMARINATE/(R)-rosmarinic acid/(+)-Rosmarinic acid/Benzenepropanoic acid, α-[[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-3,4-dihydroxy-, (αR)-/Rosemary acid/(2R)-3-(3,4-Dihydroxyphenyl)-2-{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}propanoic acid/(2R)-3-(3,4-Dihydroxyphenyl)-2-{[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoyl]oxy}propanoic acid/RosmarinicAcid/Rosmarinic acid/rosemaryacid/Rosmarinic/Rosemaricacid/Labiatenic acid/3,4-Dihydroxycinnamicacid(R)-1-carboxy-2-(3,4-dihydroxyphenyl)ethylester/(R)-O-(3,4-Dihydroxycinnamoyl)-3-(3,4-dihydroxyphenyl)lacticacid/4-dihydroxy

IUPAC Name

(2R)-3-(3,4-dihydroxyphenyl)-2-[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxypropanoic acid

Density

1.5±0.1 g/cm3

Solubility

Methanol; DMSO

Flash Point

254.5±25.0 °C

Boiling Point

694.7±55.0 °C at 760 mmHg

Melting Point

171-175 °C(lit.)

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2932990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:20283-92-5) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

29110743

Abstract

The supplementation of livestock rations with herbs containing bioactive components, such as rosmarinic acid (RA), have shown promising results as a natural feed additive in promoting growth, productive and reproductive performance, feed utilization, fertility, anti-oxidant status and immunologic indices. Furthermore, RA reportedly reduces the risks of various animal diseases and mitigates side effects of chemical and synthetic drugs. RA is a natural polyphenol present in several Lamiaceae herbs like Perilla frutescens, and RA is becoming an integral component of animal nutrition as it counters the effect of reactive oxygen species induced in the body as a consequence of different kinds of stressors. Studies have further ascertained the capability of RA to work as an anti-microbial, immunomodulatory, anti-diabetic, anti-allergic, anti-inflammatory, hepato- and renal-protectant agent, as well as to have beneficial effects during skin afflictions. Additionally, RA is favored in meat industries due to enhancing the quality of meat products by reportedly improving shelf-life and imparting desirable flavor. This review describes the beneficial applications and recent findings with RA, including its natural sources, modes of action and various useful applications in safeguarding livestock health as well as important aspects of human health.

KEYWORDS

Rosmarinic acid; animal; beneficial application; health benefits; mode of action.

Title

Rosmarinic Acid: Modes of Action, Medicinal Values and Health Benefits

Author

Mahmoud Alagawany 1 , Mohamed Ezzat Abd El-Hack 1 , Mayada Ragab Farag 2 , Marappan Gopi 3 , Kumaragurubaran Karthik 4 , Yashpal Singh Malik 5 , Kuldeep Dhama 6

Publish date

2017 Dec

PMID

29318480

Abstract

The excessive activation of microglia plays a key role in the pathogenesis of neurodegenerative diseases. The neuroprotective properties of rosmarinic acid have been reported in a variety of disease models both in vitro and in vivo; however, the mechanism underlying its anti-neuroinflammatory activity has not been clearly elucidated. In the present study, we evaluated the anti-inflammatory effects of rosmarinic acid in conditions of neuroinflammatory injury in vitro and in vivo. The results indicated that rosmarinic acid reduced the expression of CD11b, a marker of microglia and macrophages, in the brain and dramatically inhibited the levels of inflammatory cytokines and mediators, such as TNFα, IL-6, IL-1β, COX-2, and iNOS, in a dose-dependent manner both in vitro and in vivo. Consistent with these results, the expression levels of TLR4 and CD14 and the phosphorylation of JNK were also reduced. Further study showed that rosmarinic acid suppresses the activation of the NF-κB pathway and NLRP3 inflammasome, which may contribute to its anti-inflammatory effects. These results suggest that rosmarinic acid significantly reduced TLR4 and CD14 expression and NF-κB and NLRP3 inflammasome activation, which is involved in anti-neuroinflammation.

KEYWORDS

Rosmarinic acid; animal; beneficial application; health benefits; mode of action.

Title

Rosmarinic Acid Mitigates Lipopolysaccharide-Induced Neuroinflammatory Responses Through the Inhibition of TLR4 and CD14 Expression and NF-κB and NLRP3 Inflammasome Activation

Author

Yicong Wei 1 , Jianxiong Chen 2 , Yonghong Hu 2 , Wei Lu 2 , Xiaoqin Zhang 2 , Ruiguo Wang 2 , Kedan Chu 2

Publish date

2018 Mar

PMID

30328397

Abstract

Rosmarinus officinalis L. (Lamiaceae), popularly known as rosemary, is used for food flavoring, and in folk medicine, as an antispasmodic, analgesic, anti-rheumatic, diuretic, and antiepileptic agent. Rosemary is an herb widely used in folk medicine, cosmetics, and phytotherapy and for flavoring of food products. Studies have focused on various biological activities of the secondary metabolites of this plant, such as rosmarinic acid, which have powerful antioxidant, hepato-protective, antimicrobial, anti-nociceptive, and anti-inflammatory properties.

KEYWORDS

Anti-oxidant; Rosmarinus officinalis; anti-inflammatory agent; cytokines; phytotherapy; rosmarinic acid..

Title

Rosmarinic Acid as Potential Anti-Inflammatory Agent

Author

Carmela Colica 1 , Laura Di Renzo 2 , Vincenzo Aiello 3 , Antonino De Lorenzo 2 , Ludovico Abenavoli 4

Publish date

2018


Description :

Rosmarinic acid (RA) is a widespread phenolic ester compound in the plants. Rosmarinic acid inhibits MAO-A, MAO-B and COMT enzymes with IC50s of 50.1, 184.6 and 26.7 μM, respectively.