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Rubipodanone A

$538

  • Brand : BIOFRON

  • Catalogue Number : BD-P0371

  • Specification : 98.0%(HPLC)

  • CAS number : 2170211-22-8

  • Formula : C27H22O6

  • Molecular Weight : 442.47

  • PUBCHEM ID : 134715233

  • Volume : 10mg

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Catalogue Number

BD-P0371

Analysis Method

HPLC,NMR,MS

Specification

98.0%(HPLC)

Storage

2-8°C

Molecular Weight

442.47

Appearance

Powder

Botanical Source

Structure Type

Quinones

Category

SMILES

CC(=CCC1(C(=C(C2=CC=CC=C2C1=O)O)C(=O)OC)C3=CC(=O)C4=CC=CC=C4C3=O)C

Synonyms

methyl (3R)-3-(1,4-dioxonaphthalen-2-yl)-1-hydroxy-3-(3-methylbut-2-enyl)-4-oxonaphthalene-2-carboxylate

IUPAC Name

methyl (3R)-3-(1,4-dioxonaphthalen-2-yl)-1-hydroxy-3-(3-methylbut-2-enyl)-4-oxonaphthalene-2-carboxylate

Applications

Density

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

Boiling Point

Melting Point

InChl

InChI=1S/C27H22O6/c1-15(2)12-13-27(20-14-21(28)16-8-4-5-9-17(16)23(20)29)22(26(32)33-3)24(30)18-10-6-7-11-19(18)25(27)31/h4-12,14,30H,13H2,1-3H3/t27-/m1/s1

InChl Key

CDHHYGYUIPPDJB-HHHXNRCGSA-N

WGK Germany

RID/ADR

HS Code Reference

2933990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:2170211-22-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

18834922

Abstract

Leptin, a mediator of long-term regulation of energy balance, has been implicated in the release of adenohypophyseal gonadotropins by regulating gonadotropin-releasing hormone (GnRH) secretion from the hypothalamus. However, a direct effect of leptin on hormone release from gonadotropes remains virtually unexplored. In the current report, we assessed the long-term (48 h) actions of leptin on voltage-gated channel activity and luteinizing hormone (LH) production in mouse pituitary gonadotrope LβT2 cells. Electrophysiological recordings showed that leptin treatment significantly increased whole-cell patch clamp Ba2+ current through L-type Ca2+ channels. Quantitative RT-PCR analysis revealed increased levels of L-type (α1D) Ca2+ channel mRNA. Likewise, radioimmunoassays using specific antibodies provided evidence that leptin alone had no effect on LH release but did enhance GnRH-induced secretion of the hormone. Leptin had no apparent effects on LH gene transcription in absence of GnRH, as measured by transient transfection assays using a LH promoter-reporter gene and real time RT-PCR. These observations suggest that leptin might affect LH release by acting directly on the gonadotropes, favoring hormone production by enhancing responsiveness to GnRH as a result of increased Ca2+ channel expression.

KEYWORDS

Ca2+ channels, LβT2 cells, Leptin, Patch clamp, Pituitary, Gonadotropes

Title

Leptin increases L-type Ca2+ channel expression and GnRH-stimulated LH release in LβT2 gonadotropes

Author

Jose E. Avelino-Cruz,a,f Amira Flores,b Jorge Cebada,c Pamela L. Mellon,d Ricardo Felix,e and Eduardo Monjaraza,*

Publish date

2010 Jan 27.