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Rutin

$93

  • Brand : BIOFRON

  • Catalogue Number : BF-R3004

  • Specification : 95%

  • CAS number : 153-18-4

  • Formula : C27H30O16

  • Molecular Weight : 610.52

  • PUBCHEM ID : 5280805

  • Volume : 1000mg

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Catalogue Number

BF-R3004

Analysis Method

HPLC,NMR,MS

Specification

95%

Storage

2-8°C

Molecular Weight

610.52

Appearance

Yellow needle crystal

Botanical Source

Leonurus japonicus,Morus alba,Sophora japonica,Ziziphus jujuba var. spinosa,Bupleurum marginatum

Structure Type

Flavonoids

Category

Standards;Natural Pytochemical;API

SMILES

CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=C(OC4=CC(=CC(=C4C3=O)O)O)C5=CC(=C(C=C5)O)O)O)O)O)O)O)O

Synonyms

2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-3-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-({[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}methyl)tetrahydro-2H-pyran-2-yl]oxy}-4H-chromen-4-one/4H-1-Benzopyran-4-one, 3-((6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl)oxy)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-/5-18-05-00519/Tanrutin/4H-1-Benzopyran-4-one, 3-[[6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-/Quercetin 3-O-β-D-rutinosid/3,3',4',5,7-Pentahydroxyflavone 3-(O-rhamnosylglucoside)/Venoruton/Vitamin P trihydrate/Ilixathin/Quercetin 3-O-rutinoside/Quercetin 3-β-rutinoside/Rutinion acid/Osyritrin/2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl-6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside/3-((6-O-(6-Deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl)oxy)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one/Violaquercitrin/Rutozyd/Globularicitrin/Sophorin/2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-mannopyranoside/Paliuroside/2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside/Eldri/Rutabion/Rutin hydrate/Oxyritin/Rutoside/Quercetin 3-O-β-rutinoside/Rutin/Rutin trihydrate/3-[[6-O-(6-Deoxy-a-L-mannopyranosyl)-b-D-glucopyranosyl]oxy]-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one/3,3',4',5,7-Pentahydroxyflavone-3-rutinoside/Birutan/4H-1-Benzopyran-4-one, 3-[[6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]-oxy]-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-/Melin/Osyritin/Rutinic acid/Quercetin-3-O-rutinoside/Myrticolorin

IUPAC Name

2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one

Density

1.8±0.1 g/cm3

Solubility

Methanol; DMSO

Flash Point

325.4±27.8 °C

Boiling Point

983.1±65.0 °C at 760 mmHg

Melting Point

195 °C (dec.)(lit.)

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2932990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:153-18-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

26898570

Abstract

Rutin (quercetin-3-O-rutinoside) is a multifunctional natural flavonoid glycoside with profound effects on the various cellular functions under pathological conditions. Due to the ability of rutin and/or its metabolites to cross the blood brain barrier, it has also been shown to modify the cognitive and various behavioral symptoms of neurodegenerative diseases. In this review, its therapeutic potential for Alzheimer’s disease (AD) is evaluated through appraisal of current literatures relevant to the various cellular and molecular targets of the disease. Among the most relevant mechanisms involved are effect on amyloid beta (Aβ) processing, aggregation and action; alteration of the oxidant-antioxidant balance associated with neuronal cell loss; removing the inflammatory component of neurodegeneration, etc. The effect of rutin resulting from its physicochemical features related to effects like metal chelation and bioavailability are also discussed.

Title

Rutin as a Natural Therapy for Alzheimer's Disease: Insights Into Its Mechanisms of Action

Author

Solomon Habtemariam

Publish date

2016

PMID

28971760

Abstract

Flavonoids are major dietary constituents of plant-based food found ubiquitously in plant kingdom where they are usually present in substantial amounts. Rutin is a flavonol-type polyphenol which consists of the flavonol quercetin and the disaccharide rutinose. Rutin has been reported to exert diverse biological effects such as antitumor and antimicrobial mainly associated to its antioxidant and anti-inflammatory activities. Mental, neurological, and behavioural disorders are an important and growing cause of morbidity. Most of these disorders combine a high prevalence, early onset, progressive clinical course, and impairment of critical brain functions making them a major contributor to the global disease burden. In the present work, the biological in vitro and in vivo effects and the potential therapeutic applications of rutin in neurodegenerative processes are reviewed, as well as their bioavailability and pharmacokinetics, which are essential for a better understanding of its biological effectiveness. Moreover, the present review also provides an overview of the molecular mechanisms through which rutin is proposed to exert its neuroprotective effects.

Title

Rutin as Neuroprotective Agent: From Bench to Bedside

Author

Barbara Budzynska 1 , Caterina Faggio 2 , Marta Kruk-Slomka 1 , Dunja Samec 3 , Seyed Fazel Nabavi 4 , Antoni Sureda 5 6 , Kasi Pandima Devi 7 , Seyed Mohammad Nabavi 4

Publish date

2019

PMID

29017142

Abstract

Several lines of evidence suggest that flavonoids that originated from vegetables and medicinal plants have beneficial effects on diabetes by improving glycemic control, lipid profile, and antioxidant status. Rutin is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antioxidant, neuroprotective, nephroprotective, and hepatoprotective effects. In this review, the antihyperglycemic property of rutin and its protective effects against the development of diabetic complications are discussed. Proposed mechanisms for the antihyperglycemic effect of rutin include a decrease of carbohydrates absorption from the small intestine, inhibition of tissue gluconeogenesis, an increase of tissue glucose uptake, stimulation of insulin secretion from beta cells, and protecting Langerhans islet against degeneration. Rutin also decreases the formation of sorbitol, reactive oxygen species, advanced glycation end-product precursors, and inflammatory cytokines. These effects are considered to be responsible for the protective effect of rutin against hyperglycemia- and dyslipidemia-induced nephropathy, neuropathy, liver damage, and cardiovascular disorders. Taken together, the results of current experimental studies support the potential of rutin to prevent or treat pathologies associated with diabetes. Well-designed clinical studies are suggested to evaluate advantages and limits of rutin for managing diabetes.

KEYWORDS

Diabetes; Flavonoids; Glucose; Lipids; Mechanism; Rutin.

Title

Mechanisms of Antidiabetic Effects of Flavonoid Rutin

Author

Ahmad Ghorbani

Publish date

2017 Dec


Description :

Rutin, a naturally occurring flavonoid glycoside, has antioxidant, anti-inflammatory, anti-allergic, anti-angiogenic and antiviral properties.