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Salvigenin

$896

  • Brand : BIOFRON

  • Catalogue Number : BD-P0244

  • Specification : 98.0%(HPLC)

  • CAS number : 19103-54-9

  • Formula : C18H16O6

  • Molecular Weight : 328.32

  • PUBCHEM ID : 161271

  • Volume : 25mg

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Catalogue Number

BD-P0244

Analysis Method

HPLC,NMR,MS

Specification

98.0%(HPLC)

Storage

2-8°C

Molecular Weight

328.32

Appearance

Yellow powder

Botanical Source

7-O-Methylpectolinarigenin; Psathyrotin;5-Hydroxy-4',6,7-trimethoxyflavone; 5-Hydroxy-6,7,4'-trimethoxyflavone

Structure Type

Flavonoids

Category

SMILES

COC1=CC=C(C=C1)C2=CC(=O)C3=C(C(=C(C=C3O2)OC)OC)O

Synonyms

5-hydroxy-6,7-dimethoxy-2-(4-methoxyphenyl)chromen-4-one

IUPAC Name

5-hydroxy-6,7-dimethoxy-2-(4-methoxyphenyl)chromen-4-one

Applications

Density

1.3±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

196.9±23.6 °C

Boiling Point

535.9±50.0 °C at 760 mmHg

Melting Point

InChl

InChI=1S/C18H16O6/c1-21-11-6-4-10(5-7-11)13-8-12(19)16-14(24-13)9-15(22-2)18(23-3)17(16)20/h4-9,20H,1-3H3

InChl Key

QCDYOIZVELGOLZ-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

2914500000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:19103-54-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

32024626

Abstract

Plants belongs to Asteraceae family are reported to be rich in major phytochemical including flavonoids and are documented to acquire antidiabetic response. Antidiabetic effects of salvigenin, eupatilin and cirsilineol were screened on in-vitro enzyme inhibition and in-vivo streptozotocin animal models. Administration of salvigenin, eupatilin and cirsilineol (7.5 and 15mg/kg) produced antidiabteic responses in streptozotocin model for diabetes. All natural flavonoids reduces the blood glucose level to a significant level (*P<0.05, **P<0.01, ***P<0.001, n=8) but promising results were observed in eupatilin at dose of 7.5mk/kg (364.12±4.3 to 128.41±4.2mg/dL, n=8) and at dose of 7.5mk/kg 363.65±4.8 to 126.14±5.1mg/dL, n=8). Administration of salvigenin, eupatilin and cirsilineol (7.5 and 15mg/kg) for 28 days showed a substantial fall (*P<0.05, **P<0.01, ***P<0.001, n=8) in total cholesterol, LDL and triglcerides (TGs) in comparison to diabetic model. The isolated flavonoids reduced considerably the serum ALP, SGPT and SGOT in rats intoxicated with streptozotocin. The results indicate that the flavonoids may be useful in the development of new antidiabetic drugs.

Title

Antidiabetic potential of flavonoids from Artemisia macrocephalla Jaquem in streptozotocin-induced diabetic rats: Pharmacological and biochemical approach

Author

Syed Wadood-Ali Shah 1, Mehreen Ghias 1, Mohammad Shoaib 1, Niaz Ali 2, Ismail Shah 3, Muhammad Naveed Umar 4, Syed Muhammad Mukarram Shah 5, Syed Muhammad Hassan Shah 6, Wali Khan 7, Shahzeb Khan 1, Tour Jan 8, Saeed Ahmad 7, Shakir Ullah 1, Shafi Ullah 1

Publish date

2019 Nov

PMID

31678632

Abstract

Aqueous and acetone extracts of O. stamineus leaves reduce the adhesion of uropathogenic E. coli (UPEC, strain UTI89) to T24 bladder cells significantly (IC25 ~ 524 mg/mL, resp. 40 μg/mL). The acteonic extract had no cytotoxic effects against UPEC in concentrations that inhibited the bacterial adhesion. The extract significantly reduced the gene expression of fimH, fimC, fimD, csgA and focG, which are strongly involved in the formation of bacterial adhesins. The antiadhesive effect was due to the presence of polymethoxylated flavones, enriched in the acetonic extract. Five flavones have been isolated by fast centrifugal partition chromatography, followed by preparative HPLC. Eupatorin, ladanein, salvigenin, sinensetin, 5,6,7,4′-tetramethoxyflavone and 5-hydroxy-6,7,3′,4′-tetramethoxyflavone were identified as the main polymethoxylated flavones. With the exception of eupatorin, all of these flavones reduced the bacterial adhesion in a concentration depending manner, indicating that B-ring hydroxylation and methoxylation seems to have a major impact on the antiadhesive activity. In addition, this was confirmed by investigation of the flavones chrysoeriol and diosmetin, which had only very weak antiadhesive activity. From these data, Orthosiphon extracts can be assessed to have a pronounced antiadhesive activity against UPEC, based on a variety of polymethoxylated flavones.

KEYWORDS

Adhesion; Flavone; Orthosiphon stamineus; Sinensetin; Uropathogenic E. coli.

Title

Polymethoxylated flavones from Orthosiphon stamineus leaves as antiadhesive compounds against uropathogenic E. coli

Author

Melanie Deipenbrock 1, Andreas Hensel 2

Publish date

2019 Nov;

PMID

28278660

Abstract

Phytochemical investigation of n-hexane extract of Salvia sahendica by normal phase column chromatography resulted in the isolation of six compounds. Structures were established by 1D and 2D NMR spectroscopy, and HRMS, as a new norditerpene 1, and known terpenoids, sclareol (2), oleanolic acid (3), β-sitosterol (4), salvigenin (5) and 3α-hydroxy-11α,12α-epoxyoleanan-28,13β-olide (6). The absolute configuration of 1 was confirmed by a combination of X-ray single crystal analysis and electronic circular dichroism spectroscopy. In vitro cytotoxic activity on breast cancer cell line (MDA-MB-231) and also the antimicrobial activity of the pure compounds were tested against Staphylococcus aureus, Bacilus cereus and Escherichia coli.

KEYWORDS

ECD; Lamiaceae; Salvia sahendica; norditerpene; structure elucidation.

Title

A nor-diterpene from Salvia sahendica leaves

Author

Sahar Mofidi Tabatabaei 1, Peyman Salehi 1, Mahdi Moridi Farimani 1, Markus Neuburger 2, Maria De Mieri 3, Matthias Hamburger 3, Samad Nejad-Ebrahimi 1

Publish date

2017 Aug