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Sanggenol L

$605

  • Brand : BIOFRON

  • Catalogue Number : BD-P0161

  • Specification : 98.5%(HPLC)

  • CAS number : 329319-20-2

  • Formula : C25H26O6

  • Molecular Weight : 422.47

  • PUBCHEM ID : 11796489

  • Volume : 10mg

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Catalogue Number

BD-P0161

Analysis Method

HPLC,NMR,MS

Specification

98.5%(HPLC)

Storage

2-8°C

Molecular Weight

422.47

Appearance

Powder

Botanical Source

Structure Type

Flavonoids

Category

SMILES

CC(=CCCC1(C=CC2=C3C(=C(C=C2O1)O)C(=O)CC(O3)C4=C(C=C(C=C4)O)O)C)C

Synonyms

2-(2,4-dihydroxyphenyl)-5-hydroxy-8-methyl-8-(4-methylpent-3-enyl)-2,3-dihydropyrano[2,3-h]chromen-4-one

IUPAC Name

2-(2,4-dihydroxyphenyl)-5-hydroxy-8-methyl-8-(4-methylpent-3-enyl)-2,3-dihydropyrano[2,3-h]chromen-4-one

Applications

Apoptotic Effect of Sanggenol L via Caspase Activation and Inhibition of NF-κB Signaling in Ovarian Cancer Cells. PUMID/DOI:DOI:10.1002 / ptr.5505 Phytother Res. 2016 Jan;30(1):90-6. In the present study, the underlying apoptotic mechanism of sanggenol L was elucidated in ovarian cancer cells. Sanggenol L showed cytotoxic and antiproliferative effect in A2780, SKOV-3, and OVCAR-3 ovarian cancer cells in a concentration-dependent fashion. Consistently, sanggenol L increased sub-G1 phase population and early and late apoptotic portion in ovarian cancer cells. Also, sanggenol L activated caspase9/3, suppressed the phosphorylation of IκBα and p65 NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells), attenuated the expression of Cyclin D1, and cleaved poly(adenosine diphosphate ribose -ribose) polymerase in SKOV-3, A2780, and OVCAR-3 cells. Furthermore, sanggenol L blocked nuclear translocation of NF-κB and also attenuated the expression of NF-κB related genes such as c-Myc, Cyclin D1, and Bcl-X L, Bcl-2, in lipopolysaccharide-treated SKOV-3 cells. Overall, our findings for the first time suggest that sanggenol L induces apoptosis via caspase activation and inhibition of NF-κB/IκBα phosphorylation as a potent chemotherapeutic agent for ovarian cancers.

Density

1.3±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

226.4±25.0 °C

Boiling Point

660.1±55.0 °C at 760 mmHg

Melting Point

InChl

InChI=1S/C25H26O6/c1-14(2)5-4-9-25(3)10-8-17-22(31-25)13-20(29)23-19(28)12-21(30-24(17)23)16-7-6-15(26)11-18(16)27/h5-8,10-11,13,21,26-27,29H,4,9,12H2,1-3H3

InChl Key

MCDFUBPTGYOGCC-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

2933990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:329319-20-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

31061855

Abstract

The dataset presented in this data paper supports “Eggshell resorption, and embryonic mobilization and accumulation of calcium and metals in eggs of wild and captive Capercaillies Tetrao urogallus” (Orłowski et al., 2019) [1]. Here we present the supplementary data on the following: (1) egg sizes, regional eggshell thicknesses (at the equator, sharp pole and blunt pole) as well as the concentrations of two major micronutrients (Ca and Mg) and eight trace elements (Cr, Cu, Mn, Fe, Co, Cd, Pb and Zn), measured in the shells and contents of eggs of captive-bred and wild Capercaillies. (2) How the proportions of elements sequestered into eggshells become depleted during embryogenesis expressed as the %change of concentrations of various elements measured in the shells and contents of eggs at different stages of embryonic advancement (early dead embryos, late dead embryos and hatched eggs). (3) The relationships between the age of dead embryos and three regional eggshell thicknesses and concentrations of different elements measured in the shells and contents of these eggs.

Title

Supporting dataset and methods for egg sizes, eggshell thicknesses and metal concentrations measured in the shells and contents of eggs of Capercaillies Tetrao urogallus

Author

Grzegorz Orłowski,a,∗ Dorota Merta,b Przemysław Pokorny,c Ewa Łukaszewicz,d Wojciech Dobicki,c Janusz Kobielski,e Artur Kowalczyk,d Zenon Rzońca,f and Andrzej Krzywińskig

Publish date

2019 Jun;

PMID

23641949

Abstract

Background
The 2009 pandemic influenza was milder than expected. Based on the apparent lack of pre-existing cross-protective antibodies to the A (H1N1)pdm09 strain, it was hypothesized that pre-existing CD4+ T cellular immunity provided the crucial immunity that led to an attenuation of disease severity. We carried out a pilot scale study by conducting in silico and in vitro T cellular assays in healthy population, to evaluate the pre-existing immunity to A (H1N1)pdm09 strain.

Methods
Large-scale epitope prediction analysis was done by examining the NCBI available (H1N1) HA proteins. NetMHCIIpan, an eptiope prediction tool was used to identify the putative and shared CD4+ T cell epitopes between seasonal H1N1 and A (H1N1)pdm09 strains. To identify the immunogenicity of these putative epitopes, human IFN-γ-ELISPOT assays were conducted using the peripheral blood mononuclear cells from fourteen healthy human donors. All donors were screened for the HLA-DRB1 alleles.

Results
Epitope-specific CD4+ T cellular memory responses (IFN-γ) were generated to highly conserved HA epitopes from majority of the donors (93%). Higher magnitude of the CD4+ T cell responses was observed in the older adults. The study identified two HA2 immunodominant CD4+ T cell epitopes, of which one was found to be novel.

Conclusions
The current study provides a compelling evidence of HA epitope specific CD4+ T cellular memory towards A (H1N1)pdm09 strain. These well-characterized epitopes could recruit alternative immunological pathways to overcome the challenge of annual seasonal flu vaccine escape.

KEYWORDS

Influenza A/H1N1 viruses, Hemagglutinin, CD4+ T cell epitope, Immunodominant epitope, Novel conserved HA epitope

Title

T cell memory to evolutionarily conserved and shared hemagglutinin epitopes of H1N1 viruses: a pilot scale study

Author

Venkata R Duvvuri,corresponding author#1,3 Bhargavi Duvvuri,#2 Veronica Jamnik,2 Jonathan B Gubbay,4,5,6,7 Jianhong Wu,3 and Gillian E Wu1,2

Publish date

2013;