White crystalline powder
β-D-Galactopyranoside, (1β,3β,25R)-3-hydroxyspirost-5-en-1-yl O-β-D-glucopyranosyl-(1->2)-O-[β-D-xylopyranosyl-(1->3)]-6-deoxy-/(1β,3β,25R)-3-Hydroxyspirost-5-en-1-yl β-D-glucopyranosyl-(1->2)-[β-D-xylopyranosyl-(1->3)]-6-deoxy-β-D-galactopyranoside/ruscogenin 1-O-[β-D-glucopyranosyl(1->2)][β-D-xylopyranosyl(1->3)]-β-D-fucopyranoside/Liriope muscari baily Saponins C/Saponin C, from Liriope muscari
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
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For Reference Standard and R&D, Not for Human Use Directly.
provides coniferyl ferulate(CAS#:130551-41-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
Wave reflections, which are increased in patients with heart failure with preserved ejection fraction, impair diastolic function and promote pathologic myocardial remodeling. Organic nitrates reduce wave reflections acutely, but whether this is sustained chronically or affected by hydralazine coadministration is unknown.
Methods and Results
We randomized 44 patients with heart failure with preserved ejection fraction in a double‐blinded fashion to isosorbide dinitrate (ISDN; n=13), ISDN+hydralazine (ISDN+hydral; n=15), or placebo (n=16) for 6 months. The primary end point was the change in reflection magnitude (RM; assessed with arterial tonometry and Doppler echocardiography). Secondary end points included change in left ventricular mass and fibrosis, measured with cardiac magnetic resonance imaging, and the 6‐minute walk distance. ISDN reduced aortic characteristic impedance (mean baseline=0.15 [95% CI, 0.14-0.17], 3 months=0.11 [95% CI, 0.10-0.13], 6 months=0.10 [95% CI, 0.08-0.12] mm Hg/mL per second; P=0.003) and forward wave amplitude (Pf, mean baseline=54.8 [95% CI, 47.6-62.0], 3 months=42.2 [95% CI, 33.2-51.3]; 6 months=37.0 [95% CI, 27.2-46.8] mm Hg, P=0.04), but had no effect on RM (P=0.64), left ventricular mass (P=0.33), or fibrosis (P=0.63). ISDN+hydral increased RM (mean baseline=0.39 [95% CI, 0.35-0.43]; 3 months=0.31 [95% CI, 0.25-0.36]; 6 months=0.44 [95% CI, 0.37-0.51], P=0.03), reduced 6‐minute walk distance (mean baseline=343.3 [95% CI, 319.2-367.4]; 6 months=277.0 [95% CI, 242.7-311.4] meters, P=0.022), and increased native myocardial T1 (mean baseline=1016.2 [95% CI, 1002.7-1029.7]; 6 months=1054.5 [95% CI, 1036.5-1072.3], P=0.021). A high proportion of patients experienced adverse events with active therapy (ISDN=61.5%, ISDN+hydral=60.0%; placebo=12.5%; P=0.007).
ISDN, with or without hydralazine, does not exert beneficial effects on RM, left ventricular remodeling, or submaximal exercise and is poorly tolerated. ISDN+hydral appears to have deleterious effects on RM, myocardial remodeling, and submaximal exercise. Our findings do not support the routine use of these vasodilators in patients with heart failure with preserved ejection fraction.
Clinical Trial Registration
URL: www.clinicaltrials.gov. Unique identifier: NCT01516346.
heart failure, hemodynamics, magnetic resonance imaging, remodeling heart failure, vascular biology, vascular stiffness, vasodilators
Isosorbide Dinitrate, With or Without Hydralazine, Does Not Reduce Wave Reflections, Left Ventricular Hypertrophy, or Myocardial Fibrosis in Patients With Heart Failure With Preserved Ejection Fraction
Payman Zamani, MD, MTR, 1 Scott Akers, MD, PhD, 2 Haideliza Soto‐Calderon, BA, 1 Melissa Beraun, MD, 1 Maheswara R. Koppula, MD, 1 Swapna Varakantam, MD, 1 Deepa Rawat, MD, 1 Prithvi Shiva‐Kumar, MD, MS, MBA, 1 Philip G. Haines, MD, MTR, 1 , 3 Jesse Chittams, MS, 6 Raymond R. Townsend, MD, 4 Walter R. Witschey, PhD, 5 Patrick Segers, PhD, 7 and Julio A. Chirinos, MD, PhDcorresponding author 1
2017 Feb 20
Endothelial function may be deranged in Heart Failure with Preserved Ejection Fraction (HFpEF). Serum NO-derived metabolites (NOm) might provide a biochemical surrogate of endothelial function in heart failure (HF) patients. We measured serum NOm in 415 participants in the Penn HF Study. Participants with HFpEF (n=82) and participants whose EF had recovered (Recovered-HF [n=125]) were matched 1:1 to Heart Failure with Reduced Ejection Fraction (HFrEF) participants based on age, sex, race, tobacco use, and eGFR. Serum NOm levels were quantified after chemical reduction coupled with gas-phase chemiluminescence detection. After adjustment for matching covariates and BMI, HFpEF (34.5 [IQR: 25.0, 51.5] μM) participants had lower NOm levels than HFrEF (41.0 [IQR: 28.3, 58.0] μM; ratio of HFpEF:HFrEF 0.82 [95% CI: 0.67-0.99]; P=0.04), which further decreased when adjusted for covariates that impact endothelial function (ratio 0.79 [95% CI: 0.65-0.98]; P=0.03). There were no differences between HFrEF (34.0 [IQR: 25.3, 49.0]) and matched Recovered-HF (36.0 [IQR: 25.0, 55.0] μM) or HFpEF and Recovered-HF. Age (+21%/10-year increase, P<0.001) and black race (−28%, P=0.03) associated with NOm in HFpEF; whereas, age (+11%/10-year increase, P=0.03), current tobacco use (+67%, P=0.01) and eGFR (P=0.01) associated with NOm in Recovered-HF. In conclusion, HFpEF participants have reduced NOm as compared to HFrEF in this matched cohort. This might suggest either compromised endothelial function or poor dietary intake. Black race was associated with lower NOm in HFpEF.
Heart failure, endothelial function, nitric oxide, race
Effect of Heart Failure with Preserved Ejection Fraction on Nitric Oxide Metabolites
Payman Zamani, MD, MTR,a Benjamin French, PhD,b Jeffrey A. Brandimarto, MS,a Paschalis-Thomas Doulias, PhD,c Ali Javaheri, MD, PhD,d Julio A. Chirinos, MD, PhD,a Kenneth B. Margulies, MD,a Raymond R. Townsend, MD,e Nancy K. Sweitzer, MD, PhD,f James C. Fang, MD,g Harry Ischiropoulos, PhD,c and Thomas P. Cappola, MD, ScMa
2017 Dec 15.
Hiring is an opportunity for school districts to find educators with values and beliefs that align with district goals. Yet beliefs are difficult to measure. We use administrative data from more than ten thousand applications to certificated positions in an urban California school district in which applicants submitted essays about closing achievement gaps. Using structural topic modeling (STM) to code these essays, we examine whether applicants systematically differ in their use of these themes and whether themes predict hiring outcomes. Relative to white applicants, Hispanic and African American applicants are more likely to identify structural causes of inequities and discuss educators’ responsibilities for addressing inequality. Similar differences in themes emerge between applicants to schools with different student populations. Techniques like STM can decipher hard-to-measure beliefs from administrative data, providing valuable information for hiring and decision making.
teacher hiring, structural topic modeling, educational equity
Differing Views of Equity: How Prospective Educators Perceive Their Role in Closing Achievement Gaps
Emily K. Penner,corresponding authora Jane Rochmes,corresponding authorb Jing Liu,corresponding authorc Sabrina M. Solanki,corresponding authord and Susanna Loebcorresponding authore