We Offer Worldwide Shipping
Login Wishlist

Sauchinone

$143

Brand : BIOFRON
Catalogue Number : BF-S4009
Specification : 98%(HPLC)
CAS number : 177931-17-8
Formula : C20H20O6
Molecular Weight : 356.3692
PUBCHEM ID : 11725801
Volume : 25mg

In stock

Quantity
Checkout Bulk Order?

Catalogue Number

BF-S4009

Analysis Method

HPLC,NMR,MS

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

356.3692

Appearance

Yellow crystalline powder

Botanical Source

Saururus chinensis

Structure Type

Others

Category

Standards;Natural Pytochemical;API

SMILES

CC1CC2C3C(C1C)C4=CC5=C(C=C4OC36C(=CC2=O)OCO6)OCO5

Synonyms

(5aR,7R,8S,8aR,14aS,14bR)-7,8-Dimethyl-5a,6,7,8,8a,14b-hexahydro-5H-benzo[kl]bis[1,3]dioxolo[4,5-b:4',5'-g]xanthen-5-one/Sauchinone/5H-Benzo[kl][1,3]dioxolo[4,5-b]-1,3-dioxolo[4,5-g]xanthen-5-one, 5a,6,7,8,8a,14b-hexahydro-7,8-dimethyl-, (5aR,7R,8S,8aR,14aS,14bR)-

IUPAC Name

(1S,12R,13S,14R,16R,23R)-13,14-dimethyl-2,6,8,20,22-pentaoxahexacyclo[10.10.1.01,19.03,11.05,9.016,23]tricosa-3,5(9),10,18-tetraen-17-one

Density

1.4±0.1 g/cm3

Solubility

Methanol; Acetone; Ethyl Acetate

Flash Point

220.3±28.8 °C

Boiling Point

498.1±45.0 °C at 760 mmHg

Melting Point

224-226℃

InChl

InChI=1S/C20H20O6/c1-9-3-11-13(21)5-17-20(25-8-24-17)19(11)18(10(9)2)12-4-15-16(23-7-22-15)6-14(12)26-20/h4-6,9-11,18-19H,3,7-8H2,1-2H3/t9-,10+,11+,18+,19+,20+/m1/s1

InChl Key

GMTJIWUFFXGFHH-WPAOEJHSSA-N

WGK Germany

RID/ADR

HS Code Reference

2938900000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:177931-17-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

29356224

Abstract

Sauchinone is one of the active lignan isolated from Saururus chinensis, which has been considered to possess various pharmacological activities, such as antitumor, hepatoprotective, antioxidant, and anti-inflammatory effects. However, the functional roles of sauchinone in interleukin-1 beta (IL-1β)-stimulated human osteoarthritis (OA) chondrocytes are still unknown. Thus, in this study, we investigated the anti-inflammatory effects of sauchinone in IL-1β-stimulated chondrocytes. Our results demonstrated that sauchinone significantly attenuated NO and PGE2 production, as well as inhibited iNOS and COX-2 expression in IL-1β-stimulated OA chondrocytes. In addition, sauchinone efficiently inhibited IL-1β-induced MMP-3 and MMP-13 release in human OA chondrocytes. Furthermore, sauchinone significantly attenuated the activation of NF-κB in human OA chondrocytes. In conclusion, we showed for the first time that sauchinone inhibited inflammatory response in IL-1β-stimulated human chondrocytes probably through inhibiting the activation of NF-κB signaling pathway. These data suggest that sauchinone may be a potential agent in the treatment of OA.

KEYWORDS

chondrocyte; inflammatory response; osteoarthritis; sauchinone.

Title

Sauchinone Prevents IL-1β-induced Inflammatory Response in Human Chondrocytes

Author

Yanjun Gao 1 , Hongyu Zhao 2 , Yang Li

Publish date

2018 Mar

PMID

29499410

Abstract

Sauchinone, one of the active lignan isolated from the roots of Saururus chinensis, was reported to possess diverse pharmacological properties, such as hepatoprotective, anti-inflammatory and anti-tumor effects. However, the possible role of sauchinone in the epithelial-mesenchymal transition (EMT) remains unclear. Thus, the aim of this study was to investigate the effect of sauchinone on the EMT in gastric cancer cells. Our results demonstrated that sauchinone significantly inhibited transforming growth factor-β1 (TGF-β1)-induced migration and invasion in gastric cancer cells. In addition, sauchinone efficiently suppressed TGF-β1-induced EMT process in gastric cancer cells. Furthermore, pretreatment with sauchinone dramatically inhibited the activation of PI3K/Akt and Smad2/3 signaling pathways in TGF-β1-stimulated gastric cancer cells. In conclusion, our findings revealed that sauchinone inhibits the TGF-β1-induced EMT in gastric cancer cells via down-regulation of PI3K/Akt and Smad2/3 signaling pathways. Thus, sauchinone may be a therapeutic agent for treatment of gastric cancer.

KEYWORDS

chondrocyte; inflammatory response; osteoarthritis; sauchinone.

Title

Sauchinone Prevents TGF-β-induced EMT and Metastasis in Gastric Cancer Cells

Author

Zhikuan He 1 , Wenxing Dong 2 , Quanying Li 1 , Changjiang Qin 1 , Yongjun Li 3

Publish date

. 2018 May

PMID

29425147

Abstract

Herb-drug interaction (HDI) limits clinical application of herbs and drugs, and inhibition of herbs towards uridine diphosphate (UDP)-glucuronosyltransferases (UGTs) has gained attention as one of the important reasons to cause HDIs. Sauchinone, an active lignan isolated from aerial parts of Saururus chinensis (Saururacease), possesses anti-oxidant, anti-inflammatory, and anti-viral activities. In pharmacokinetics of sauchinone, sauchinone is highly distributed to the liver, forming extensive metabolites of sauchinone via UGTs in the liver. Thus, we investigated whether sauchinone inhibited UGTs to explore potential of sauchinone-drug interactions. In human liver microsomes (HLMs), sauchinone inhibited activities of UGT1A1, 1A3, 1A6, and 2B7 with IC50 values of 8.83, 43.9, 0.758, and 0.279 μM, respectively. Sauchinone also noncompetitively inhibited UGT1A6 and 2B7 with Ki values of 1.08 and 0.524 μM, respectively. In in vivo interaction study using mice, sauchinone inhibited UGT2B7-mediated zidovudine metabolism, resulting in increased systemic exposure of zidovudine when sauchinone and zidovudine were co-administered together. Our results indicated that there is potential HDI between sauchinone and drugs undergoing UGT2B7-mediated metabolism, possibly contributing to the safe use of sauchinone and drug combinations.

KEYWORDS

Saururus chinensis; UGT2B7; drug interaction; inhibition; sauchinone.

Title

Inhibitory Effect of Sauchinone on UDP-Glucuronosyltransferase (UGT) 2B7 Activity

Author

Byoung Hoon You 1 , Eun Chae Gong 2 , Young Hee Choi 3

Publish date

2018 Feb 9