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Scillascillin

$1,152

  • Brand : BIOFRON

  • Catalogue Number : BN-O1486

  • Specification : 98%(HPLC)

  • CAS number : 52706-07-7

  • Formula : C17H12O6

  • Molecular Weight : 312.277

  • PUBCHEM ID : 75492722

  • Volume : 5mg

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Catalogue Number

BN-O1486

Analysis Method

HPLC,NMR,MS

Specification

98%(HPLC)

Storage

-20℃

Molecular Weight

312.277

Appearance

Powder

Botanical Source

This product is isolated and purified from the herbs of Scilla scilloides

Structure Type

Flavonoids

Category

Standards;Natural Pytochemical;API

SMILES

C1C2=CC3=C(C=C2C14COC5=CC(=CC(=C5C4=O)O)O)OCO3

Synonyms

Spiro[2H-1-benzopyran-3(4H),5'(6'H)-cyclobuta[f][1,3]benzodioxol]-4-one, 5,7-dihydroxy-, (3R)-/(3R)-5,7-Dihydroxy-4H,6'H-spiro[chromene-3,5'-cyclobuta[f][1,3]benzodioxol]-4-one

IUPAC Name

(3R)-5,7-dihydroxyspiro[2H-chromene-3,4'-9,11-dioxatricyclo[6.3.0.03,6]undeca-1(8),2,6-triene]-4-one

Density

1.7±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

233.3±25.0 °C

Boiling Point

607.3±55.0 °C at 760 mmHg

Melting Point

InChl

InChI=1S/C17H12O6/c18-9-2-11(19)15-14(3-9)21-6-17(16(15)20)5-8-1-12-13(4-10(8)17)23-7-22-12/h1-4,18-19H,5-7H2/t17-/m0/s1

InChl Key

SAXOGBBWXWKZKR-KRWDZBQOSA-N

WGK Germany

RID/ADR

HS Code Reference

2932990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:52706-07-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

24686192

Abstract

The rhesus macaque exhibits age-related brain changes similar to humans, making an excellent model of normal aging. Calorie restriction is a dietary intervention that reduces age-related comorbidities in short-lived animals, and its effects are still under study in rhesus macaques. Here, using deterministic fiber tracking method, we examined the effects of age and calorie restriction on a diffusion tensor imaging measure of white matter integrity, fractional anisotropy (FA), within white matter tracks traversing the anterior (genu) and posterior (splenium) corpus callosum in rhesus monkeys. Our results show: (1) a significant inverse relationship between age and mean FA of tracks traversing the genu and splenium; (2) higher mean FA of the splenium tracks as compared to that of genu tracks across groups; and (3) no significant diet effect on mean track FA through either location. These results are congruent with the age-related decline in white matter integrity reported in humans and monkeys, and the anterior-to-posterior gradient in white matter vulnerability to normal aging in humans. Further studies are warranted to critically evaluate the effect of calorie restriction on brain aging in this unique cohort of elderly primates.

Title

Effect of age and calorie restriction on corpus callosal integrity in rhesus macaques: a fiber tractography study

Author

Aadhavi Sridharan,b,c Barbara B Bendlin,a,d,e Catherine Gallagher,a,f Jennifer M Oh,a,d,e Auriel A Willette,a,d,e,1 Andrew L Alexander,g Joseph W Kemnitz,h,i Ricki J Colman,j Richard H Weindruch,a and Sterling C Johnsona,d,e

Publish date

2015 May 21.

PMID

9311857

Abstract

NTPase activities in mammalian reovirus cores were examined under various conditions that permitted several new differences to be identified between strains type 1 Lang (T1L) and type 3 Dearing (T3D). One difference concerned the ratio (at pH 8.5) of ATP hydrolysis at 50 degrees C to that at 35 degrees C. A genetic analysis using T1L x T3D reassortant viruses implicated the L3 and M1 gene segments in this difference, with M1 influencing ATPase activity most strongly at high temperatures. L3 and M1 encode the core proteins lambda1 and mu2, respectively. Another difference concerned the absolute levels of GTP hydrolysis by cores at 45 degrees C and pH 6.5. A genetic analysis using T1L x T3D reassortants implicated the M1 gene as the sole determinant of this difference. The results of these experiments, coupled with previous findings (S. Noble and M. L. Nibert, J. Virol. 71:2182-2191, 1997), suggest either that a single type of NTPase in cores is strongly influenced by two different core proteins–lambda1 and mu2–or that cores contain two different types of NTPase influenced by the two proteins. The findings appear relevant for understanding the complex functions of reovirus cores in RNA synthesis and capping.

Title

Core protein mu2 is a second determinant of nucleoside triphosphatase activities by reovirus cores.

Author

S Noble, M L Nibert

Publish date

1997 Oct

PMID

29385479

Abstract

Parasitic diseases have economic consequences in cattle production systems. Although breeding for parasite resistance can complement current control practices to reduce the prevalence globally, there is little knowledge of the implications of such a strategy on other performance traits. Records on individual animal antibody responses to Fasciola hepatica, Ostertagia ostertagi, and Neospora caninum were available from cows in 68 dairy herds (study herds); national abattoir data on F. hepatica-damaged livers were also available from dairy and beef cattle. After data edits, 9,271 dairy cows remained in the study herd dataset, whereas 19,542 dairy cows and 68,048 young dairy and beef animals had a record for the presence or absence of F. hepatica-damaged liver in the national dataset. Milk, reproductive, and carcass phenotypes were also available for a proportion of these animals as well as their contemporaries. Linear mixed models were used to estimate variance components of antibody responses to the three parasites; covariance components were estimated between the parasite phenotypes and economically important traits. Heritability of antibody responses to the different parasites, when treated as a continuous trait, ranged from 0.07 (O. ostertagi) to 0.13 (F. hepatica), whereas the coefficient of genetic variation ranged from 4% (O. ostertagi) to 20% (F. hepatica). The antibody response to N. caninum was genetically correlated with the antibody response to both F. hepatica (−0.29) and O. ostertagi (−0.67); a moderately positive genetic correlation existed between the antibody response to F. hepatica and O. ostertagi (0.66). Genetic correlations between the parasite phenotypes and the milk production traits were all close to zero (−0.14 to 0.10), as were the genetic correlations between F. hepatica-damaged livers and the carcass traits of carcass weight, conformation, and fat score evaluated in cows and young animals (0.00 to 0.16). The genetic correlation between F. hepatica-damaged livers in cows and milk somatic cell score was 0.32 (SE = 0.20). Antibody responses to F. hepatica and O. ostertagi had favorable genetic correlations with fertility traits, but conversely, antibody response to N. caninum and F. hepatica-damaged livers were unfavorably genetically correlated with fertility. This study provides the necessary information to undertake national multitrait genetic evaluations for parasite phenotypes.

KEYWORDS

carcass, Fasciola hepatica, fertility, milk, Neospora caninum, Ostertagia ostertagi

Title

Genetic correlations between endo-parasite phenotypes and economically important traits in dairy and beef cattle

Author

Alan J Twomey, Rebecca I Carroll, Michael L Doherty, Noel Byrne, David A Graham, Riona G Sayers, Astrid Blom, Donagh P Berry

Publish date

2018 Feb


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