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Scopolamine butylbromide

$78

  • Brand : BIOFRON

  • Catalogue Number : BF-S2001

  • Specification : 98%

  • CAS number : 149-64-4

  • Formula : C21H30BrNO4

  • Molecular Weight : 440.37

  • PUBCHEM ID : 6852391

  • Volume : 20mg

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Catalogue Number

BF-S2001

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

-20℃

Molecular Weight

440.37

Appearance

White crystalline powder

Botanical Source

herbs of Atropa belladonna L.

Structure Type

Alkaloids

Category

Standards;Natural Pytochemical;API

SMILES

CCCC[N+]1(C2CC(CC1C3C2O3)OC(=O)C(CO)C4=CC=CC=C4)C.[Br-]

Synonyms

(1R,2R,4S,5S,7s,9S)-9-Butyl-7-{[(2S)-3-hydroxy-2-phenylpropanoyl]oxy}-9-methyl-3-oxa-9-azoniatricyclo[3.3.1.0]nonane bromide/(−)-N-Butylscopolamine bromide (−)-Scopolamine N-butyl bromide Hyoscine N-butyl bromide/3-Oxa-9-azoniatricyclo[3.3.1.0]nonane, 9-butyl-7-[(2S)-3-hydroxy-1-oxo-2-phenylpropoxy]-9-methyl-, bromide, (1R,2R,4S,5S)- (1:1)/Scopolamine butylbromide/Hyoscine butylbromide/Hyoscinen buty1bromide

IUPAC Name

[(1S,2S,4R,5R)-9-butyl-9-methyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonan-7-yl] (2S)-3-hydroxy-2-phenylpropanoate;bromide

Density

Solubility

Methanol; Water

Flash Point

Boiling Point

Melting Point

InChl

InChI=1S/C21H30NO4.BrH/c1-3-4-10-22(2)17-11-15(12-18(22)20-19(17)26-20)25-21(24)16(13-23)14-8-6-5-7-9-14;/h5-9,15-20,23H,3-4,10-13H2,1-2H3;1H/q+1;/p-1/t15?,16?,17-,18-,19-,20+,22?;/m0./s1

InChl Key

HOZOZZFCZRXYEK-GXLSIKBRSA-M

WGK Germany

RID/ADR

HS Code Reference

2939800000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:149-64-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

30564875

Abstract

BACKGROUND/AIM:
Cholinergic syndrome frequently occurs within the first 24 h after irinotecan injection. We evaluated the prophylactic effect of scopolamine butylbromide on irinotecan-related cholinergic syndrome.

PATIENTS AND METHODS:
Fifty-nine patients who received irinotecan-based regimens at our outpatient chemotherapy clinic between April 2013 and May 2014 were enrolled. Patients who developed irinotecan-related cholinergic syndrome were prophylactically administered scopolamine butylbromide at the next scheduled treatment. Risk factors for irinotecan-related cholinergic syndrome were determined using logistic regression analysis.

RESULTS:
Irinotecan-related cholinergic syndrome occurred in 50.8% of patients. Scopolamine butylbromide administration significantly reduced the incidence to 3.4% (P < 0.01). The irinotecan dose (≥ 150 mg/m2) was the only risk factor associated with irinotecan-related cholinergic syndrome. The incidence of cholinergic syndrome in patients with this risk factor was 75%.

CONCLUSION:
Scopolamine butylbromide was effective in preventing irinotecan-related cholinergic syndrome. It is recommended for patients receiving ≥ 150 mg/m2 irinotecan who may develop cholinergic syndrome at high frequency.

KEYWORDS

Cholinergic syndrome; Irinotecan; Scopolamine butylbromide

Title

Prophylactic effect of scopolamine butylbromide, a competitive antagonist of muscarinic acetylcholine receptor, on irinotecan-related cholinergic syndrome.

Author

Iihara H1, Fujii H1, Yoshimi C1, Kobayashi R1, Matsuhashi N2, Takahashi T2, Yoshida K2, Suzuki A3.

Publish date

2019 Mar;

PMID

30496789

Title

Response to "Hyoscine Butylbromide for the Management of Death Rattle: Sooner Rather Than Later".

Author

Boland JW1, Currow D2, Johnson M3.

Publish date

2019 Mar

PMID

30367928

Title

Letter to the Editor Re: "Hyoscine Butylbromide for the Management of Death Rattle: Sooner Rather Than Later".

Author

Clark K1, Sheehan C2, Currow DC3.

Publish date

2019 Jan


Description :

Scopolamine butylbromide is a competitive antagonist of muscarinic acetylcholine receptor (mAChR) with an IC50 of 55.3 ± 4.3 nM.Target: mAChRScopolamine (USAN), also known as levo-duboisine and hyoscine, sold as Scopoderm, is a tropane alkaloid drug with muscarinic antagonist effects. It is among the secondary metabolites of plants from Solanaceae (nightshade) family of plants, such as henbane, jimson weed (Datura), angel's trumpets (Brugmansia), and corkwood (Duboisia). Scopolamine exerts its effects by acting as a competitive antagonist at muscarinic acetylcholine receptors, specifically M1 receptors; it is thus classified as an anticholinergic, antimuscarinic drug. Its use in medicine is relatively limited, with its chief uses being in the treatment of motion sickness and postoperative nausea and vomiting. Scopolamine is named after the plant genus Scopolia. The name "hyoscine" is from the scientific name for henbane, Hyoscyamus niger.