senkyunolide-C/Senkyunolide C/(3Z)-3-Butylidene-5-hydroxy-2-benzofuran-1(3H)-one/1(3H)-Isobenzofuranone, 3-butylidene-5-hydroxy-, (3Z)-/5-hydroxy-3-butylidenephthalide/(Z)-5-Hydroxy-3-butylidene-phthalide
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
387.1±42.0 °C at 760 mmHg
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provides coniferyl ferulate(CAS#:91652-78-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
The safe and effective administration of fluids and medications during the management of medical emergencies in children depends on an appropriately determined dose, based on body weight. Weight can often not be measured in these circumstances and a convenient, quick and accurate method of weight estimation is required. Most methods in current use are not accurate enough, but the newer length-based, habitus-modified (two-dimensional) systems have shown significantly higher accuracy. This meta-analysis evaluated the accuracy of weight estimation systems in children. Articles were screened for inclusion into two study arms: to determine an appropriate accuracy target for weight estimation systems; and to evaluate the accuracy of existing systems using standard meta-analysis techniques. There was no evidence found to support any specific goal of accuracy. Based on the findings of this study, a proposed minimum accuracy of 70% of estimations within 10% of actual weight (PW10 > 70%), and 95% within 20% of actual weight (PW20 > 95%) should be demonstrated by a weight estimation system before being considered to be accurate. In the meta-analysis, the two-dimensional systems performed best. The Mercy method (PW10 70.9%, PW20 95.3%), the PAWPER tape (PW10 78.0%, PW20 96.6%) and parental estimates (PW10 69.8%, PW20 87.1%) were the most accurate systems investigated, with the Broselow tape (PW10 55.6%, PW20 81.2%) achieving a lesser accuracy. Age-based estimates achieved a very low accuracy. Age- and length-based systems had a substantial difference in over- and underestimation of weight in high-income and low- and middle-income populations. A benchmark for minimum accuracy is recommended for weight estimation studies and a PW10 > 70% with PW20 > 95% is suggested. The Mercy method, the PAWPER tape and parental estimates were the most accurate weight estimation systems followed by length-based and age-based systems. The use of age-based formulas should be abandoned because of their poor accuracy.
Electronic supplementary material
The online version of this article (10.1186/s12245-017-0156-5) contains supplementary material, which is available to authorized users.
Weight estimation, Broselow tape, PAWPER tape, Mercy method
The accuracy of emergency weight estimation systems in children—a systematic review and meta-analysis
Mike Wells,corresponding author1,2 Lara Nicole Goldstein,1 and Alison Bentley1
In the title compound, C17H12F3NO4S, the heterocyclic thiazine ring adopts a half-chair conformation with the S and the N atoms displaced by −0.608 (3) and 0.105 (3) a, respectively, from the mean plane formed by the remaining ring atoms. The dihedral angle between the two benzene rings is 36.63 (8)° and the acetic acid group is inclined at right angles [89.78 (8) °] to the mean plane formed by the C atoms of the thiazine ring. The crystal structure features O—H⋯O and C—H⋯O hydrogen bonds.
Yanchun Yang,a Youzhu Yu,b and Changjin Zhua,*
2012 May 1
Recent studies proposed reasonable doubts about the good prognosis of very high levels of high-density lipoprotein cholesterol (HDL-c). We aimed to investigate the association between HDL-c levels and all-cause mortality using data from an observational cohort study in northern China from 2006 to 2015. The study population was stratified into six groups by HDL-c levels in mg/dl (<40, 40-49, 50-59, 60-69, 70-79, ≥80). Cox hazards regression models were used to estimate the association between HDL-c levels and all-cause mortality. In total, 100,070 participants (aged 51.9 ± 12.7 years) were included in the current analysis. During a mean follow-up of 8.76 years, 7,362 deaths were identified (mortality rate, 8.40 per 1000 person-years). There was a significant interaction effect between age and HDL-c levels (P for interaction < 0.001). Among individuals aged 65 and older, no significant association was found between HDL-c levels and total mortality. In contrast, HDL-c levels showed a U-shaped relationship with all-cause mortality in younger participants (<65 years old), and very high HDL-c levels (≥80 mg/dl) were independently associated with increased total mortality risk compared with the reference level (60 to 69 mg/dl). These findings suggest that very high HDL-c levels may not represent a good prognosis, especially in younger individuals. Subject terms: Risk factors, Lifestyle modification
Association between high-density lipoprotein cholesterol and all-cause mortality in the general population of northern China
Xintao Li,#1 Bo Guan,#1 Yanjun Wang,1 Gary Tse,2,3 Fuquan Zou,3 Bin Waleed Khalid,3 Yunlong Xia,3 Shouling Wu,corresponding author4 and Jianhui Suncorresponding author1