White crystalline powder
Callerya speciosa,Duhaldea nervosa,Aster auriculatus,Aster tataricus
(1R,4aS,4bS,6aS,8R,10aR,10bS,12aS)-1,4b,6a,8,10a,12a-Hexamethyl-8-(4-methylpent-3-en-1-yl)hexadecahydrochrysen-2(1H)-one/SHIONONE/21-Shionen-3-one/(1R,4aS,4bS,6aS,8R,10aR,10bS,12aS)-1,4b,6a,8,10a,12a-Hexamethyl-8-(4-methyl-3-penten-1-yl)hexadecahydro-2(1H)-chrysenone/2(1H)-Chrysenone, hexadecahydro-1,4b,6a,8,10a,12a-hexamethyl-8-(4-methyl-3-penten-1-yl)-, (1R,4aS,4bS,6aS,8R,10aR,10bS,12aS)-/3b,5a,8,17ab-Tetramethyl-3-(4-methyl-3-pentenyl)-D-homoandrostan-17-one/18,19-Seco-D:A-friedolup-19-en-3-one/D:A-Friedo-18,19-secolup-19-en-3-one
Methanol; Chloroform; Ethyl Acetate; Dichloromethane
485.6±14.0 °C at 760 mmHg
HS Code Reference
Personal Projective Equipment
For Reference Standard and R&D, Not for Human Use Directly.
provides coniferyl ferulate(CAS#:10376-48-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
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Study on anti-inflammatory mechanism of shionone based on NF-κB pathway in vitro PUMID/DOI：无 China Journal of Traditional Chinese Medicine & Pharmacy, 2016(4):1430-3. To explore anti-inflammatory effect and mechanism of Shionone in vitro. Methods: Lipopolysaccharide(LPS)-activated macrophage cells(RAW264.7) were employed as an inflammatory model, which was intervened by the Shionone. After the experiment, Western blot was used to detect the protein expression of p-ERK1/2, IκBαand iNOS on the macrophage cells. Results: Compared with the LPS group, the Shionone significantly decreased the protein expression of p-ERK1/2 and i NOS(P0.05) and significantly increased the protein expression of IκBα(P0.05). Conclusion: The antiinflammatory mechanism of Shionone was related to decrease the phosphorylation level of ERK1/2 protein and IκBα and the protein expression of i NOS. Inhibitory effect of shionone on activity of ubiquitin-specific protease 2 PUMID/DOI：无 Journal of Shanghai Jiaotong University, 2014, 34(11):1563-7. To identify new ubiquitin-specific protease 2 (USP2) inhibitors from natural compounds. Methods: The Ub-CHOP-Reporter Kit was used to screen USP2 inhibitors. NB4 cells were treated by Shionone (SH) of 100 μmol/L for different periods of time. Variations of the expression of USP2 targeted protein Cyclin D1 were detected by the Western blotting. The distribution of cell cycle was detected by the flow cytometry and molecular docking was used to analyze the binding of SH and USP2. Results: The results of screening in vitro showed that SH inhibited the activity of USP2 with the 50% inhibition concentration (IC50) of 69 μmol/L. The results of Western blotting indicated that SH led to the decrease of Cyclin D1 expression. The results of flow cytometry showed that typical apoptotic peak (Sub-G1 peak) appeared and cells in S and G2/M phases decreased after being treated by SH for 48 h. The results of molecular docking indicated that the oxygen atom and skeleton core of SH and K503, W439, R363, and D440 of USP2 were essential for the binding of SH and USP2. Conclusion: SH can inhibit the activity of USP2 and provide a lead compound for future development of new USP2 inhibitors.